UAC 194 - MURINE MONOCLONAL ANTIBODY HD37/DG RICIN A CHAIN LYMPHOMA

UAC 194 - 鼠单克隆抗体 HD37/DG 蓖麻毒素 A 链淋巴瘤

• 批准号: 3783526
• 负责人: ALBERT F LO BUGLIO
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3783526
• 关键词: B lymphocyte; animal tissue; clinical trials; dosage; drug screening /evaluation; human subject; immune tolerance /unresponsiveness; immunoconjugates; immunotoxicity; lymphoma; monoclonal antibody; neoplasm /cancer immunotherapy; pharmacokinetics; ricin

This is a Phase I study to determine the toxicity and MTD of the deglycosylatered Ricin A chain immunoconjugate in patients with B-cell lymphoma. The pharmacokinetics and immune response will also be studied.

这是一项I阶段研究，以确定该毒性和MTD B细胞患者的脱胶糖基脂蛋白A链免疫偶联物 淋巴瘤。 还将研究药代动力学和免疫反应。