NEW DRUG DEVELOPMENT CLINICAL TRIALS IN SOLID TUMORS

实体瘤新药开发临床试验

• 批准号: 3608097
• 负责人: ALAN YAGODA
• 金额: $ 2.59万
• 依托单位: MEMORIAL HOSPITAL FOR CANCER & ALLIED DI
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-15 至 1986-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3608097
• 关键词: bladder neoplasm; blood chemistry; blood tests; bone neoplasms; breast neoplasms; carcinoembryonal antigen; cervix neoplasms; combination cancer therapy; head /neck neoplasm; histopathology; human subject; human therapy evaluation; kidney neoplasms; lung neoplasms; lymphoma; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; neoplasm /cancer therapy; ovary neoplasms; pancreas neoplasms; prostate neoplasms; sarcoma; stomach neoplasms; testis neoplasms; urinalysis; uterus neoplasms

Furnish all necessary personnel, labor, patients, facilities, equipment, materials, and supplies required to conduct Phase II and Phase III studies in patients with disseminated solid tumors such as: cancers of the lung, breast, prostate, bladder, kidney, testicle, ovary, endometrium, cervix, head and neck, stomach, pancreas, and colon, as well as lymphomas, melanomas, and bone and soft tissue sarcomas. Seventy-five patients are required for the first four month period with 250 patients per year for the next four years. The final year of the contract is for patient treatment and follow-up only. Patients to be studied, accrued, and treated for each tumor type to be dictated by the particular protocols approved.

提供所有必要的人员、劳动力、患者、设施、设备、 进行第二阶段和第三阶段研究所需的材料和用品 患有播散性实体瘤的患者，例如：肺癌、乳腺癌、 前列腺、膀胱、肾脏、睾丸、卵巢、子宫内膜、子宫颈、头颈、 胃、胰腺和结肠癌，以及淋巴瘤、黑色素瘤、骨癌和软癌 组织肉瘤。 前四个月需要七十五名患者 在接下来的四年里，每年有 250 名患者。 最后一年 该合同仅适用于患者治疗和随访。 患者要 对每种肿瘤类型进行研究、积累和治疗 批准的特定协议。

项目成果

Phase II trial of carboplatin in patients with adenocarcinomas of the upper gastrointestinal tract.

卡铂治疗上消化道腺癌的 II 期试验。

• 发表时间: 1985
• 期刊: Cancer treatment reports
• 作者: Einzig,A;Kelsen,DP;Cheng,E;Sordillo,P;Heelan,R;Winn,R;Magill,G
• 通讯作者: Magill,G

Phase II trial of N-methylformamide for advanced renal cell carcinoma.

N-甲基甲酰胺治疗晚期肾细胞癌的 II 期试验。

• 发表时间: 1986
• 期刊: Cancer treatment reports
• 作者: Sternberg,CN;Yagoda,A;Scher,HI;Hollander,P
• 通讯作者: Hollander,P

Phase II trial of etoposide in adenocarcinomas of the upper gastrointestinal tract.

依托泊苷治疗上消化道腺癌的 II 期试验。

• 发表时间: 1983
• 期刊: Cancer treatment reports
• 作者: Kelsen,DP;Magill,GB;Cheng,E;Dukeman,M;Sordillo,P;Heelan,R;Yagoda,A
• 通讯作者: Yagoda,A

Cisplatin, vindesine, and mitoguazone in the treatment of esophageal cancer.

• 发表时间: 1986-02
• 期刊: Cancer treatment reports
• 作者: D. Kelsen;R. Fein;C. Coonley;R. Heelan;M. Bains

Clinical and pathological evaluation of response to chemotherapy in patients with esophageal carcinoma.

食管癌患者化疗反应的临床和病理评价。

• 发表时间: 1983
• 期刊: American journal of clinical oncology
• 作者: Kelsen,DP;Heelan,R;Coonley,C;Bains,M;Martini,N;Hilaris,B;Golbey,RB
• 通讯作者: Golbey,RB