CLINICAL AND NEUROCHEMICAL SUBTYPES OF ADD

ADD 的临床和神经化学亚型

• 批准号: 3087998
• 负责人: STEVEN R. PLISZKA
• 金额: $ 6.05万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3087998
• 关键词: attention deficit disorder; bioassay; catecholamines; child (0-11); clinical anxiety; clinical trials; high performance liquid chromatography; human subject; imipramine; interview; male; mass spectrometry; medical education; methylphenidate; neural transmission; neurochemistry; neuropharmacology; psychological tests; psychopharmacology; urinalysis

This is a request for an NIMH Physician Scientist Award. The first two years focus on providing the awardee with training and supervison in the areas of (1) neuropsychopharmacology. Particularly with ragard to catecholamiane function in children, (2) the neurobiological processes associated with neurotransmitter function, (3) the relevent laboratory methodology of High performance-Liquid chromatography, Mass Spectrometry and enzymatic assays, and (4) measurement of attention and impulse control in children via standardize computer laboratory tools. In the last three years, this knowledge will be used to carry out a researach project under the direction of the sponsor and research advisor. The study will compare four groups of boys diagnosed by structured interview: (1) Attention Deficit Disorder (ADD) only, (2) ADD with concurrent Conduct Disorder, (3) ADD with concurrent Overanxious of the child's behavior using a standardized scoring system, and cognitive testing will be obtained at baseline. Each subject with ADD will then particiapte in a double-blind medication trail of two dosage levels of methylphenidate and imipramine. The study will examine if (1) differences in noradrenergic functioning exist between the three subgroups of ADD and the Overanxious group, and (2) children with ADD will respond differently to imipramine or methylphenidate based on the presence of conduct or anxiety symptoms.

这是NIMH医师科学家奖的要求。 第一个 两年的重点是为获奖者提供培训和 （1）神经心理药理学领域的监督。 特别是在儿童的Catecholamiane功能的Ragard时， （2）与神经递质相关的神经生物学过程 功能，（3）高的相关实验室方法论 性能液色谱法，质谱和酶促法 测定和（4）测量注意力和冲动控制 通过标准化计算机实验室工具的儿童。 在最后 三年，这些知识将用于进行研究 在赞助商和研究顾问的指导下进行项目。 该研究将比较四组由结构化诊断的男孩 访谈：（1）注意力缺陷障碍（仅添加），（2）添加 并发性障碍，（3）同时添加 使用标准评分系统的孩子的行为，以及 认知测试将在基线时获得。 每个主题都与 然后，添加将在两个两次的双盲药物踪迹中分解 哌醋甲酯和丙咪胺的剂量水平。 研究将 检查（1）去甲肾上腺素能功能的差异是否存在 在ADD的三个亚组和过度焦虑的组之间 （2）患有添加的儿童对丙咪嗪或 基于行为或焦虑的存在 症状。