NEUROIMAGING OF INHIBITION & STIMULANT RESPONSE IN ADHD

抑制的神经影像

• 批准号: 6469956
• 负责人: STEVEN R. PLISZKA
• 金额: $ 29.95万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6469956
• 关键词: adolescence (12-20); age difference; attention deficit disorder; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; caudate nucleus; cingulate gyrus; clinical research; clinical trials; evoked potentials; functional magnetic resonance imaging; gender difference; human subject; human therapy evaluation; interview; magnetic resonance imaging; mathematical model; mental disorder chemotherapy; methylphenidate; middle childhood (6-11); neuropsychological tests; prefrontal lobe /cortex; psychopharmacology; reading disorder; statistics /biometry

DESCRIPTION: (provided by applicant) The overall objective of this project is to develop a system-level model of brain-behavior relationships in ADHD. This proposal builds on previous findings of the P1 and CoPIs using a combination of event-related potentials (ERP), behavioral tasks, anatomical magnetic resonance imaging (MRI) and neuropsychology assessments in ADHD children. In the proposed project, we will use a within-subject, multi-methodological approach to clarify the relationship between anatomical and functional imaging abnormalities in ADHD. We will obtain ERP, event-related functional MRI (ER-fMRI), and anatomical MRI at baseline in four cohorts of subjects: ADHD subjects with no history of psychopharmacological treatment, ADHD subjects who have been chronically treated with stimulant medication, subjects with Reading Disorders (RD) who have no history of ADHD or psychopharmacological treatment, and control subjects. Subjects will perform both the ERP and the Stroop task during the ERP and ER-fMRI studies. After baseline studies, ADHD subjects will undergo a 5-week double blind placebo controlled trial of methylphenidate to establish if a child is a responder or non-responder to methyiphenidate and to determine, for the responders, which is the optimal dose. Subjects with ADHD will then undergo ERP and er-fMRI twice more, once on placebo and once on the best dose of stimulant, again performing the Stroop and Stop Signal Task. Our hypotheses are: 1) Relative to controls and RD subjects, ADHD children will show decreased right frontal and anterior cingulate volume as well as decreased caudate volume. 2) On ERP, ADHD subjects will show decreased N200 and P3a responses to the stop signal on ERP and decreased anterior medial negativity to Incongruent vs. Congruent stimuli on the Stroop. 3) On er-fMRI, they will show decreased activity in the anterior cingulate during the Stroop task, and decreased right inferior prefrontal cortex (PFC) activity in response to the stop signal. 4) ERP and er-fMRI differences in ADHD children will be attenuated on methyiphenidate relative to placebo. The magnitude of these changes will correlate with clinical response of ADHD symptoms to methylphenidate. 5) We will control for effects of gender and age, in particular girls with ADHD may not show the same neurobiological mechanisms as boys.

描述：（由申请人提供）该项目的总体目标是 开发多动症中脑行为关系的系统级模型。该提案是建立在P1和COPI的先前发现的基础上的 事件相关电位（ERP），行为任务，解剖磁共振 ADHD儿童的成像（MRI）和神经心理学评估。在提议中 项目，我们将使用主题内的多种方法学方法来澄清 解剖和功能成像异常之间的关系 多动症。我们将获得ERP，与事件相关的功能MRI（ER-FMRI），并且 基线的解剖学MRI在四个受试者中：ADHD受试者无 心理药物治疗的历史，多动症患者 长期用刺激药物治疗的受试者患有阅读障碍 （RD）没有多动症或心理药物治疗史，并且 控制对象。受试者将同时执行ERP和Stroop任务 ERP和ER-FMRI研究。基线研究后，多动症受试者将接受 为期5周的双盲安慰剂对照试验的哌醋甲酯以建立 如果儿童是呼吸者或对甲化替象的响应者，并确定，确定 对于响应者，这是最佳剂量。然后，ADHD的受试者将 再过两次ERP和ER-FMI，一次安慰剂，一次以最佳剂量 刺激剂，再次执行stroop并停止信号任务。我们的假设 是：1）相对于对照组和RD受试者，多动症儿童将显示下降 右侧额和前扣带回体积以及尾状尾巴减少 体积。 2）在ERP上，ADHD受试者将显示N200的减少和P3A的响应 ERP上的停止信号并降低了对不一致的内侧负效率 vs.一致的刺激。 3）在ER-FMRI上，它们将显示下降 在Stroop任务期间的前扣带回中的活动，右降低 响应停止信号的下额叶皮层（PFC）活性。 4） ADHD儿童的ERP和ER-FMRI差异将减弱 相对于安慰剂的甲化苯丙胺酸酯。这些变化的幅度将 与ADHD症状对哌醋甲酯的临床反应相关。 5）我们 将控制性别和年龄的影响，尤其是多动症的女孩 与男孩没有相同的神经生物学机制。