BRAIN CONTROL\GASTRIC SECRETION & STRESS-INDUCED LESIONS

大脑控制胃分泌

• 批准号: 3075837
• 负责人: YVETTE FRANCE TACHE
• 金额: $ 6.13万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3075837
• 关键词: autonomic nervous system; bombesin; brain mapping; central nervous system; central neural pathway /tract; corticotropin releasing factor; dorsal motor nucleus; gastric juice; gastrointestinal circulation; histamine; laboratory rat; microinjections; neuroendocrine system; neuropeptides; peptic ulcer; serotonin; spinal cord mapping; stomach; stomach emptying; stomach motility /pressure; stress; thyrotropin releasing hormone

Previously, we obtained evidence that specific neuropeptides, such as bombesin-like peptides, thyrotropin-releasing factor, corticotropin-releasing factor, somatostatin, opioid peptides and calcitonin gene-related peptide, act within the brain to influence gastric secretion, contractility and emptying and the ulcerogenic response to stress. These findings and reports by other investigators have delineated a new concept related to brain peptidergic regulation of gastric function. The objectives of the research program will be to develop further such field of investigation to reach a better understanding of brain regulation of gastric secretory and motor function. The specific aims will be 1) to localize brain sites of action of bombesin, TRH, and CRF to influence gastric function and stress ulceration using microinjection of peptides in specific brain nucleus containing nerve terminal fibers and/or receptors for these peptides 2) to elucidate the neurohumoral pathways mediating the information from brain sites to the stomach using surgical, pharmacological and electrophysiological techniques, 3) to assess the physiologic role of these peptides using selective antagonists and passive immunization. Such studies will yield important information on brain structures, pathways and neurotransmitters involved in brain regulation of gastric function and have relevant implications in the understanding of the pathogenesis of stress ulcer and eating disorders associated with alteration of gastric emptying.

以前，我们获得了特定神经肽的证据， 例如类似孟买的肽，甲状腺蛋白释放因子， 皮质激素释放因子，生长抑素，阿片类肽和 降钙素基因相关的肽在大脑内作用以影响 胃分泌，收缩和排空和溃疡性 对压力的反应。 这些发现和报告的报告 调查人员描述了与大脑有关的新概念 胃功能的替代性调节。 研究计划的目标将是进一步发展 这样的调查领域以更好地理解 胃分泌和运动功能的大脑调节。 这 具体目标是1）定位大脑的作用位点 孟买，TRH和CRF影响胃功能和压力 使用特定脑中的肽微注射溃疡 含有神经末端纤维和/或受体的细胞核 这些肽2）阐明了神经肿瘤的途径 使用 手术，药理和电生理技术，3） 使用选择性评估这些肽的生理作用 拮抗剂和被动免疫。 这样的研究将产生有关大脑结构的重要信息， 参与大脑调节的途径和神经递质 胃功能，并在 了解压力性溃疡和进食的发病机理 与胃排空改变有关的疾病。