AURICULAR ACUPUNCTURE EFFECT ON COCAINE CRAVING

耳针对可卡因渴望的影响

• 批准号: 2411848
• 负责人: THERESE K KILLEEN
• 金额: $ 1.42万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-23 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2411848
• 关键词: acupuncture /acupressure; alternative medicine; clinical research; cocaine; cues; drug abuse therapy; drug addiction; drug withdrawal; ear; human subject; human therapy evaluation; nursing intervention; placebos; questionnaires

This study will use a pretest posttest crossover design with subjects serving as their own controls to test the efficacy of auricular acupuncture interventions in diminishing psychological and physiological changes associated with cocaine craving in treatment seeking cocaine dependent patients. Cocaine craving is conceptualized as a multidimensional drive state with psychological and/or physiological correlates that often lead to drug consumption. Auricular acupuncture is an intervention consisting of insertion of needles into specific areas in the ear for the purpose of alleviating distressing symptoms associated with drug addiction and withdrawal. Ear point locations specifically targeted for drug withdrawal will represent the "real" acupuncture intervention. Ear point locations not targeted for any specific therapeutic benefit will represent the "sham" or placebo acupuncture. Thirty subjects will be randomized to receive either the real or sham acupuncture first. Twenty-four hours later each subject will receive the other acupuncture intervention. Subjects will be exposed to a cocaine cue before and after each intervention in order to simulate a craving. Cues are internal and/or external stimuli that serve as drug using reminders. A ten minute video showing individuals using cocaine will be utilized as the cue exposure. Psychological (Cocaine Craving Questionnaire-NOW) and physiological (electrodermal activity) changes associated with cocaine craving will be measured after the initial cue exposure but before the interventions, as well as after the interventions and a repeated cue exposure. Data will be analyzed using analysis of covariance (ANCOVA).

本研究将使用受试者的前测后测交叉设计 作为自己的对照来测试耳穴疗法的功效 针灸干预可降低心理和 治疗中与可卡因渴望相关的生理变化 寻找可卡因依赖患者。可卡因渴望被概念化 作为一种多维驱动状态，具有心理和/或 通常会导致药物消耗的生理相关性。耳廓 针灸是一种将针插入体内的干预措施 耳朵的特定区域，以减轻痛苦 与药物成瘾和戒断相关的症状。耳点 专门针对戒毒的地点将代表 “真正的”针灸干预。耳穴位置不针对 任何具体的治疗效果都将代表“假”或安慰剂 针刺。三十名受试者将被随机分配接受 首先进行真针灸或假针灸。每科二十四小时后 将接受其他针灸干预。科目将是 在每次干预之前和之后暴露于可卡因提示，以便 模拟一种渴望。线索是提供服务的内部和/或外部刺激 作为药物使用提醒。一段十分钟的视频显示个人使用 可卡因将被用作提示暴露。心理（可卡因 渴望问卷-NOW）和生理（皮电活动） 与可卡因渴望相关的变化将在 初始提示暴露，但在干预之前以及之后 干预和重复的提示暴露。数据将使用以下方式进行分析 协方差分析（ANCOVA）。