NEURODEVELOPMENTAL TRAJECTORIES OF REWARD PROCESSING IN VERY EARLY EMERGING RISK FOR DEPRESSION

早期出现抑郁风险时奖励处理的神经发育轨迹

基本信息

批准号：
10064646
负责人：
Michael S Gaffrey
金额：
$ 55.8万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10064646
关键词：
7 year old Address Age Amygdaloid structure Anhedonia Behavioral Biological Markers Brain Brain region Child Clinical Consumption Data Development Developmental Course Disease Early identification Emotional Emotions Environment Event-Related Potentials Feedback Functional Magnetic Resonance Imaging Future Goals Human Impairment Individual Individual Differences Investigation Knowledge Lead Learning Life Link Major Depressive Disorder Measures Medial Mental Depression Mentored Patient-Oriented Research Career Development Award Methods Moods Morbidity - disease rate National Institute of Mental Health Negative Valence Neurobiology Nursery Schools Outcome Positive Valence Prefrontal Cortex Prevalence Preventive treatment Procedures Public Health Recording of previous events Research Research Domain Criteria Research Personnel Research Priority Rewards Risk Risk Factors Sampling Source Strategic Planning System Techniques Testing Time Training Work age group behavior measurement clinical application connectome depressive symptoms disability disorder risk early onset endophenotype follow up assessment hedonic imaging modality learned behavior neuroimaging novel positive emotional state programs recruit relating to nervous system response reward processing therapy development

项目摘要

ABSTRACT Neuroimaging studies of depression have suggested that reduced brain reactivity to gain is significantly linked to diminished hedonic tone (i.e., anhedonia) and future Major Depressive Disorder (MDD). This work has also suggested that increased brain reactivity to loss may be a key biomarker of increased negative emotionality in MDD and risk for depression as well. Despite compelling findings suggesting that diminished hedonic tone and increased negative emotionality are significant risk factors for MDD in preschoolers, there have been very few investigations examining the developmental timing of altered neural reactivity to gain and loss and increased early emotional risk for depression at this age. The purpose of proposed study is to begin filling this knowledge gap. To facilitate this goal, complimentary functional magnetic resonance imaging (fMRI) and event related potential (ERP) measures of response to gain and loss will be collected in 200 4-7 year olds at two time points 1-year apart. Measures of reward learning, suggested to be a key mechanism linking reduced hedonic tone to later MDD, will also be collected and examined for potential relationships with brain reactivity to reward. An expert interdisciplinary team of investigators and consultants will support the proposed research plan. The feasibility of the proposed project is enhanced by the study team's well established history of recruiting and following large samples of preschoolers and in obtaining high quality fMRI and ERP data in children this young using developmentally sensitive methods to acclimate and train them for the demands of these environments. A systematic approach investigating brain reactivity to gain and loss will be conducted at the level of individual brain regions previously shown to be critical for reward processing and disrupted in depression. It is hypothesized that diminished brain reactivity to gain at baseline will be associated with diminished hedonic tone and reward learning measured at baseline and 1 year later. Similarly, it is hypothesized that increased brain reactivity to loss at baseline will be associated with increased negative emotionality at baseline and 1 year later. It is also hypothesized that 1) increasing brain reactivity to gain between baseline and follow-up assessments will predict increased hedonic tone and reward learning 1 year later and that 2) decreases in brain reactivity to loss during this time will predict decreased negative emotionality 1 year later. Importantly, the current study will investigate whether fMRI and ERP measures of brain reactivity to gain and loss act similarly in the hypothesized relationships. By studying how brain reactivity to gain and loss in preschoolers is associated with early alterations in emotion processing that increase risk for depression at this age, the current study may reveal unique and early occurring neurobiological markers and neurodevelopmental trajectories of risk for continued mood difficulties and/or later MDD. By further investigating whether fMRI and ERP function similarly in study predictions, information critical for the future clinical use of these methods to support earlier identification and develop novel treatments minimizing depression's public health burden will also be gained.

抽象的抑郁症的神经影像学研究表明，大脑对增益的反应性降低显着联系减少享乐主义语调（即Anhedonia）和未来的主要抑郁症（MDD）。这项工作也有建议增加对损失的大脑反应性可能是增加负面情绪性的关键生物标志物 MDD和抑郁症的风险。尽管有令人信服的发现表明享乐主义语调和负面情绪增加是学龄前儿童MDD的重要危险因素，很少有调查研究改变神经反应性的发展时机以增加和损失并增加在这个年龄段的抑郁症的早期情绪风险。拟议研究的目的是开始填写这一知识差距。为了促进这一目标，免费的功能磁共振成像（fMRI）和事件相关潜在的（ERP）对增益和损失的响应量度将在200个4-7岁的孩子中在两个时间点收集相距1年。奖励学习的度量，建议是将享乐主义语调与享乐主义语调联系起来的关键机制后来的MDD还将被收集并检查与大脑反应性以奖励的潜在关系。一个专业的研究人员和顾问团队将支持拟议的研究计划。这拟议项目的可行性得到了研究团队良好的招聘历史和按照大量的学龄前儿童样本，并在儿童中获得高质量的fMRI和ERP数据。使用发育敏感的方法来适应和训练它们满足这些环境的需求。调查大脑反应性增长和损失的系统方法将在个人水平上进行先前证明的大脑区域对于奖励加工至关重要，并且在抑郁症中被破坏。这是假设在基线时大脑反应性降低将与享乐人减少有关基线和1年后测量的语气和奖励学习。同样，假设增加基线时对损失的大脑反应性将与基线时的负面情绪增加有关一年后。还假设1）提高大脑反应性以在基线和随访之间增益评估将预测享乐语调的提高和1年后的奖励学习，并且2）减少在此期间，大脑对损失的反应性将预测1年后的负面情绪下降。重要的是，当前的研究将调查fMRI和ERP对增益和损失的反应性的测量是否类似在假设的关系中。通过研究大脑对学龄前儿童增长和损失的反应性与情绪处理的早期改变有关，以增加该年龄段抑郁症的风险研究可能揭示了独特的和早期发生的神经生物学标记和神经发育轨迹持续情绪困难和/或以后的MDD风险。通过进一步研究fMRI和ERP功能是否功能同样，在研究预测中，这些方法对这些方法的未来临床使用至关重要还将获得识别和开发新颖的治疗方法，以最大程度地减少抑郁症的公共卫生负担。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Editorial: Shedding Light on the Early Neurobiological Roots of Infant Temperament and Risk for Anxiety.

社论：揭示婴儿气质和焦虑风险的早期神经生物学根源。

DOI：
10.1016/j.jaac.2021.03.008
发表时间：
2021
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry
影响因子：
13.3
作者：
Gaffrey,MichaelS
通讯作者：
Gaffrey,MichaelS

Exploring the Association Between EEG Microstates During Resting-State and Error-Related Activity in Young Children.

探索幼儿静息状态下脑电图微状态与错误相关活动之间的关联。

DOI：
10.1007/s10548-023-01030-2
发表时间：
2023
期刊：
Brain topography
影响因子：
2.7
作者：
Bagdasarov,Armen;Roberts,Kenneth;Brunet,Denis;Michel,ChristophM;Gaffrey,MichaelS
通讯作者：
Gaffrey,MichaelS

Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects.

DOI：
10.1016/j.dcn.2022.101134
发表时间：
2022-10
期刊：
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
影响因子：
4.7
作者：
Bagdasarov, Armen;Roberts, Kenneth;Brechet, Lucie;Brunet, Denis;Michel, Christoph M.;Gaffrey, Michael S.
通讯作者：
Gaffrey, Michael S.

Associations between pre-pandemic authoritative parenting, pandemic stressors, and children's depression and anxiety at the initial stage of the COVID-19 pandemic.