Mindfulness Meditation for the treatment of women with PTSD and SUD

正念冥想治疗患有 PTSD 和 SUD 的女性

• 批准号: 8860800
• 负责人: THERESE K KILLEEN
• 金额: $ 36.55万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8860800
• 关键词: Address; Adoption; Affective; Aftercare; Alcohol or Other Drugs use; Alcohols; Area; Awareness; Back; Behavior Therapy; Client satisfaction; Cognitive; Communities; Comorbidity; Confidence Intervals; Data; Detection; Diagnosis; Disease; Drug abuse; Drug usage; Early Intervention; Enrollment; Epidemiologic Studies; Equipment and supply inventories; Evaluation; Focus Groups; Frequencies; Grant; Group Therapy; Hybrids; Individual; Intervention; Kentucky; Legal; Maintenance; Manuals; Measures; Modification; Monitor; NIH Program Announcements; Obsessive compulsive behavior; Outcome; Outcome Measure; Outpatients; Patient Self-Report; Patients; Pilot Projects; Population; Post-Traumatic Stress Disorders; Preclinical Drug Evaluation; Preventive Intervention; Procedures; Process; Provider; Randomized; Randomized Controlled Trials; Risk; Sample Size; Sampling; Schedule; Severities; Social Functioning; Staging; Substance Use Disorder; Suggestion; Suicide attempt; Supervision; Symptoms; Time; Training; Trauma; Treatment outcome; Urine; Violence; Woman; Women' s Group; base; behavior change; clinically relevant; disorder later incidence prevention; drinking; effective therapy; emotion dysregulation; emotion regulation; follow-up; interest; men; mindfulness; mindfulness meditation; novel; physical abuse; post intervention; primary outcome; programs; public health relevance; randomized trial; safety testing; satisfaction; substance abuse treatment; therapy development; treatment adherence; treatment as usual; treatment effect; treatment program

 DESCRIPTION (provided by applicant): This study is a stage 1b behavioral therapy development grant exploring the use of Mindfulness Based Relapse Prevention (MBRP), an efficacious eight session group therapy for the treatment of individuals with substance use disorders, in women with comorbid PTSD and SUD enrolled in community substance abuse treatment. The MBRP manual will be adapted to address PTSD, specifically emotional dysregulation and reactivity. PTSD symptoms contributes to the onset and maintenance of substance use so addressing both disorders in an integrated fashion is indicated for successful outcomes. Women with comorbid PTSD and SUD represent a large proportion of patients treated in community substance abuse treatment. The revised manual will be piloted in a randomized control study with 80 women enrolled in women's intensive outpatient treatment. PTSD symptoms severity, substance use outcomes and measures of mindfulness and emotional regulation will be assessed at baseline, weekly throughout the intervention, post intervention and at 3-, and 6- month follow- ups. Women will be randomized to either MBRP plus treatment as usual (TAU) or TAU alone in a 2 (MBRP) to 1 (control) randomization schedule. The MBRP group will replace a trauma focused group routinely conducted in TAU. Outcomes process evaluation during the course of the project will guide the refinement of the manual to address issues related to PTSD. This proposed study addresses several of the program announcement specific areas of interest: 1) drug abuse treatment interventions, including interventions for patients with comorbidities, in diverse settings, 2) understanding the essential components and mechanism of behavior change using MBRP intervention, 3) treatment training and supervision to include procedures for adapting the intervention and fidelity measures for feasibility to be disseminated to community providers. Patient satisfaction and provider acceptability, feasibility and ease of implementation will be monitored to increase the potential for program adoption. If data gathered in this project is promising with an effect size estimation obtained, a larger randomized controlled study will be developed.

 描述（由申请人提供）：本研究是一项 1b 阶段行为治疗开发资助，旨在探索基于正念的复发预防 (MBRP) 的使用，这是一种有效的八疗程团体疗法，用于治疗患有物质使用障碍的个体，以及患有共病 PTSD 的女性SUD 参与社区药物滥用治疗，将针对 PTSD 进行调整，特别是情绪失调和反应性症状有助于药物使用的发生和维持，从而解决这两种疾病。合并 PTSD 和 SUD 的女性占社区药物滥用治疗患者的很大一部分，修订后的手册将在一项随机对照研究中进行试点，其中 80 名女性参加了女性 PTSD 症状强化门诊治疗。将在基线、干预期间每周、干预后以及 3 个月和 6 个月随访时评估严重程度、药物使用结果以及正念和情绪调节测量。女性将像往常一样被随机分配到 MBRP 加治疗组。 (TAU) 或单独的 TAU 在 2 (MBRP) 到 1（对照）随机化方案中 MBRP 组将取代 TAU 中常规进行的创伤重点组，结果过程评估将指导手册的完善。解决与创伤后应激障碍 (PTSD) 相关的问题。这项拟议的研究涉及了该计划公告的几个具体感兴趣领域：1) 药物滥用治疗干预措施，包括在不同环境中对患有合并症的患者进行干预，2) 了解行为的基本组成部分和机制。使用 MBRP 干预进行改变，3) 治疗培训和监督，包括调整干预措施和忠诚度措施的程序，以向社区提供者传播患者满​​意度和提供者​​的可接受性、可行性和实施的难易程度，以增加项目的潜力。如果该项目中收集的数据有希望并获得效应大小估计，则将开展更大规模的随机对照研究。