DO HOSTILITY AND STRESS PREDICT CV MORTALITY IN MRFIT

敌意和压力可以预测 MRFIT 中的 CV 死亡率吗

• 批准号: 2910655
• 负责人: KAREN MATTHEWS
• 金额: $ 12.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2000-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2910655
• 关键词: angers; audiotape; behavioral /social science research tag; cardiovascular disorder epidemiology; clinical research; clinical trials; depression; disease /disorder proneness /risk; health behavior; health surveys; human data; human mortality; interview; longitudinal human study; male; prognosis; psychological stressor; psychometrics; statistics /biometry; stress; type A /type B personality

This application proposed to test the hypothesis that high levels of hostility, depressive symptoms, and stressful life events will be associated with all cause and cardiovascular disease (CVD) mortality after 16 years of follow-up in the Multiple Risk Factor Intervention Trial (MRFIT). MRFIT was a randomized, multicenter primary prevention trial designed to determine whether a special intervention consisting of smoking cessation, cholesterol reduction and control of high blood pressure, would result in a significant reduction in coronary heart disease (CHD) mortality, compared to usual care. The sample is composed of 12,866 men who at the time of study entry were in the top 15 percent of a risk score distribution based on the Framingham Heart Study data, but had no clinical evidence of CHD. During the trial, annual measurements were taken, which included some health behaviors, stressful life events, feelings of anger and hostility. A subset of 3,110 men also were administered once the Type A Structured Interview from which Potential for Hostility can be rated and all men who survived until the sixth year of the trial were administered the CES-Depression scale. After approximately 7 years of the active phase of the trial, the men have been followed for an additional 9 years for mortality and cause of death. To test the major study hypotheses, we will code all Type A Structured Interview tapes for Potential for Hostility, and components of hostility (Style, Intensity, Content) and we will construct and validate a self-report measure of hostility from items administered to all participants. Cox proportional hazard regression techniques will be used to test the association of hostility, depression, and stressful life events with all cause and CVD mortality. If the major study hypotheses are confirmed, then educational attainment, baseline risk factors, change in risk factors, and adherence indicators will be included in subsequent analyses. The proposed project presents a unique opportunity to test in a cost-efficient manner the association of psychosocial factors and mortality in a large, well characterized sample of middle-aged men.

该申请提出了测试高水平的假设 敌意，抑郁症状和压力大的生活事件将是 与所有原因和心血管疾病（CVD）死亡率相关 经过16年的随访，多重风险因素干预 试验（MRFIT）。 MRFIT是一种随机的多中心初级预防 旨在确定是否包括特殊干预措施的试验 戒烟，减少胆固醇和控制高血 压力将大大降低冠心心 与通常的护理相比，疾病（CHD）死亡率。 样品组成 在学习进入时，有12,866名男子排名前15％ 基于弗雷明汉心脏研究数据的风险评分分布， 但没有冠心病的临床证据。 在试用期间，年度 进行了测量，其中包括一些健康行为，压力很大 生活事件，愤怒和敌意的感觉。 3,110名男子的子集 一旦A型A型访谈也被管理 可以将敌意的潜力得到评分，所有幸存下来直到 试验的第六年是CES抑郁量表。 经过大约7年的试验阶段，这些人 又遵循了9年的死亡和原因 死亡。 为了检验主要的研究假设，我们将编码所有类型A 结构化的访谈录像带，以实现敌对的潜力和组件 敌对（风格，强度，内容）的 验证从管理的项目中验证敌对措施的自我报告 所有参与者。 COX比例危害回归技术将 用于测试敌对，抑郁和压力的关联 所有原因和CVD死亡率的生活事件。 如果主要研究 确认假设，然后是教育程度，基线风险 因素，风险因素的变化以及依从性指标将是 随后分析中包括。 拟议的项目提出了独特的 以经济高效方式进行测试的机会 大型，表现良好的样本中的社会心理因素和死亡率 中年男子。