EUKARYOTIC MRNA PROCESSING CONFERENCE

真核mRNA加工会议

• 批准号: 2885076
• 负责人: Adrian R Krainer
• 金额: $ 0.6万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-22 至 2000-07-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2885076
• 关键词: RNA splicing; eukaryote; meeting /conference /symposium; messenger RNA; posttranscriptional RNA processing; travel

The proposed conference on "Eukaryotic mRNA Processing": will convene scientists studying various aspects of mRNA splicing and 3'-end processing mechanisms and regulation in higher eucaryote and in yeast. Major advances have recently been made in these areas, and the proposed conference will be a timely event for discussing the latest unpublished results and exchanging idea, therapy fostering new developments in this rapidly moving field. The proposed conference will be held on August 25-29, 199 and is the second meeting of a conference that is held every other year at Cold Spring Harbor Laboratory. The first meeting was held on August 20-24, 1997, and attracted 272 scientists internationally, who are actively investigating various aspects of messenger RNA maturation, particularly mRNA splicing and polyadenylation, but the scope will now be slight expanding to encompass nuclear mRNA editing. The meeting format will consist of seven plenary sessions and three poster sessions. Speakers in the plenary sessions will be will be selected on the basis of the submitted abstracts which will encourage active participation by junior scientists. The main topics covered will include: catalytic mechanisms and specificity of mRNA splicing and 3'-end processing: developmental and cell-type specific regulation of gene expression by alterative splicing and polyadenylation; structure and function of snRNP particles and of hnRNPs, SR proteins, PRPs, and other yeast, metazoan, and/or plant protein factors involved in splicing of polyadenylation; spliceosome assembly; nuclear mRNA editing; mRNA turnover; and localization and dynamics of processing reactions, factors, substrates, and products, in relation to nuclear architecture and to nuclear- cytoplasmic transport.

拟议的关于“真核mRNA加工”的会议：将召集研究mRNA剪接的各个方面和3'-End加工机制和较高酵母中的调节的各个方面。最近在这些领域取得了重大进展，拟议的会议将是一个及时的活动，用于讨论最新的未发表结果和交换思想，培训在这个快速移动的领域中促进新事态发展。拟议的会议将于199年8月25日至29日举行，是一次会议的第二次会议，每隔一年在冷泉港实验室举行一次会议。第一次会议于1997年8月20日至24日举行，在国际上吸引了272名科学家，他们正在积极研究Messenger RNA成熟的各个方面，尤其是mRNA剪接和多腺苷酸化，但现在的范围将略有扩展以包含核mRNA编辑。会议格式将由七个全体会议和三个海报会议组成。全体会议的演讲者将根据提交的摘要进行选择，这将鼓励初级科学家积极参与。涵盖的主要主题将包括：mRNA剪接的催化机理和特异性和3'-End加工：通过替换剪接和聚腺苷酸化对基因表达的发育和细胞类型特异性调节； SNRNP颗粒以及HNRNP，SR蛋白，PRPS和其他酵母，后生动物和/或植物蛋白因子涉及聚丙基化剪接的结构和功能；剪接组装；核mRNA编辑； mRNA离职；以及与核结构和核细胞质转运有关的加工反应，因素，底物和产物的定位和动力学。