2008 The Biology of Post-Transcriptional Gene Regulation Gordon Research Conferen

2008 转录后基因调控生物学戈登研究会议

• 批准号: 7476630
• 负责人: Adrian R Krainer
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476630
• 关键词: Address; Area; Biogenesis; Biology; Catalysis; Coupling; Defect; Disease; Evolution; Fertilization; Functional RNA; Functional disorder; Gene Expression Regulation; Genetic Transcription; Genomics; Goals; Health; Hereditary Disease; Human; Human Genome; Learning; Maine; Malignant Neoplasms; Mediating; Messenger RNA; Metabolism; MicroRNAs; Neurologic; Neuromuscular Diseases; Participant; Principal Investigator; Public Health; RNA; RNA Processing; RNA Splicing; RNA Transport; Regulation; Request for Proposals; Research; Research Personnel; Series; Signal Transduction; Students; Transfer RNA; Translations; college; day; improved; interest; mRNA Decay; posters; programs; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for a Gordon Research Conference on The Biology of Post-Transcriptional Gene Regulation, to be held at Colby College in Waterville, Maine, from June 29 to July 4, 2008. This meeting is the third one of a Gordon Conference series held every other year. The broad and long-term goal of the conference is to improve our current understanding of fundamental mechanisms and regulation of RNA biogenesis in normal and disease states. The emphasis is on post- transcriptional transactions involving mRNA, but this extends to transcriptional coupling, and to factors involved in translation and its control, including tRNA and microRNAs. The specific aims of this meeting will be to convene approximately 45 speakers representing key areas of post-transcriptional gene regulation, with a total of 150 participants, for a five-day meeting. The program will consist of nine morning or evening sessions that will broadly address cutting-edge issues in: coupling between transcription and RNA processing; genomics and evolution of RNA-processing signals and factors; RNA splicing catalysis, fidelity, regulation, and involvement in disease; RNA turnover, including nonsense-mediated mRNA decay; RNA transport and localization; non-coding RNA; and translational control. In addition, small poster sessions on four late afternoons will enable all participants to contribute to, and learn about, these topics. Free early- afternoon and late-evening periods in the relatively isolated summer setting of Colby College will stimulate productive, informal discussions among established and junior principal investigators, postdoctoral trainees and graduate students from the U.S. and abroad. The significance of this application is that this GRC has a unique format and brings together sets of researchers who, despite having converging interests, have infrequent opportunities to meet as a group. The resulting discussions and cross- fertilization will help define critical areas to propel this field forward. In addition, elucidating the basic mechanisms of post-transcriptional gene regulation will be essential to gain a full understanding of the organization, function, and evolution of the human genome. The health relatedness of this application reflects the extensive involvement of RNA-processing dysfunction in numerous genetic diseases, neurological and neuromuscular disorders, and cancer. PUBLIC HEALTH RELEVANCE The relevance of this application to public health reflects the extensive involvement of defects in RNA metabolism associated with many human genetic diseases, neurological and neuromuscular disorders, and cancer. In addition, elucidating the basic mechanisms of the steps of gene regulation that are the focus of this conference, will be essential to gain a full understanding of the organization, function, and evolution of the human genome.

描述（由申请人提供）：本提案请求部分支持将于 2008 年 6 月 29 日至 7 月 4 日在缅因州沃特维尔科尔比学院举行的关于转录后基因调控生物学的戈登研究会议。戈登会议系列的第三次会议每隔一年举行一次。这次会议的广泛和长期目标是提高我们目前对正常和疾病状态下 RNA 生物发生的基本机制和调控的理解。重点是涉及 mRNA 的转录后事务，但这也延伸到转录耦合，以及涉及翻译及其控制的因子，包括 tRNA 和 microRNA。本次会议的具体目标是召集代表转录后基因调控关键领域的约 45 名发言人，总共 150 名与会者，举行为期五天的会议。该计划将包括九场上午或晚上的会议，将广泛解决以下领域的前沿问题：转录和 RNA 处理之间的耦合； RNA 处理信号和因子的基因组学和进化； RNA剪接催化、保真度、调节和参与疾病； RNA 周转，包括无义介导的 mRNA 衰减； RNA运输和定位；非编码RNA；和平移控制。此外，四个下午晚些时候举行的小型海报会议将使所有参与者能够对这些主题做出贡献并了解这些主题。在科尔比学院相对偏僻的夏季环境中，下午早些时候和晚上的空闲时间将激发来自美国和国外的资深和初级首席研究员、博士后实习生和研究生之间富有成效的非正式讨论。该应用程序的重要性在于，该 GRC 具有独特的格式，并将多组研究人员聚集在一起，尽管他们有共同的兴趣，但很少有机会作为一个群体见面。由此产生的讨论和交叉融合将有助于确定推动该领域向前发展的关键领域。此外，阐明转录后基因调控的基本机制对于全面了解人类基因组的组织、功能和进化至关重要。该应用的健康相关性反映了RNA加工功能障碍在许多遗传疾病、神经和神经肌肉疾病以及癌症中的广泛参与。公共健康相关性 该应用与公共健康的相关性反映了与许多人类遗传疾病、神经和神经肌肉疾病以及癌症相关的RNA代谢缺陷的广泛参与。此外，阐明本次会议的重点基因调控步骤的基本机制对于全面了解人类基因组的组织、功能和进化至关重要。