2008 The Biology of Post-Transcriptional Gene Regulation Gordon Research Conferen

2008 转录后基因调控生物学戈登研究会议

• 批准号: 7476630
• 负责人: Adrian R Krainer
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476630
• 关键词: Address; Area; Biogenesis; Biology; Catalysis; Coupling; Defect; Disease; Evolution; Fertilization; Functional RNA; Functional disorder; Gene Expression Regulation; Genetic Transcription; Genomics; Goals; Health; Hereditary Disease; Human; Human Genome; Learning; Maine; Malignant Neoplasms; Mediating; Messenger RNA; Metabolism; MicroRNAs; Neurologic; Neuromuscular Diseases; Participant; Principal Investigator; Public Health; RNA; RNA Processing; RNA Splicing; RNA Transport; Regulation; Request for Proposals; Research; Research Personnel; Series; Signal Transduction; Students; Transfer RNA; Translations; college; day; improved; interest; mRNA Decay; posters; programs; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for a Gordon Research Conference on The Biology of Post-Transcriptional Gene Regulation, to be held at Colby College in Waterville, Maine, from June 29 to July 4, 2008. This meeting is the third one of a Gordon Conference series held every other year. The broad and long-term goal of the conference is to improve our current understanding of fundamental mechanisms and regulation of RNA biogenesis in normal and disease states. The emphasis is on post- transcriptional transactions involving mRNA, but this extends to transcriptional coupling, and to factors involved in translation and its control, including tRNA and microRNAs. The specific aims of this meeting will be to convene approximately 45 speakers representing key areas of post-transcriptional gene regulation, with a total of 150 participants, for a five-day meeting. The program will consist of nine morning or evening sessions that will broadly address cutting-edge issues in: coupling between transcription and RNA processing; genomics and evolution of RNA-processing signals and factors; RNA splicing catalysis, fidelity, regulation, and involvement in disease; RNA turnover, including nonsense-mediated mRNA decay; RNA transport and localization; non-coding RNA; and translational control. In addition, small poster sessions on four late afternoons will enable all participants to contribute to, and learn about, these topics. Free early- afternoon and late-evening periods in the relatively isolated summer setting of Colby College will stimulate productive, informal discussions among established and junior principal investigators, postdoctoral trainees and graduate students from the U.S. and abroad. The significance of this application is that this GRC has a unique format and brings together sets of researchers who, despite having converging interests, have infrequent opportunities to meet as a group. The resulting discussions and cross- fertilization will help define critical areas to propel this field forward. In addition, elucidating the basic mechanisms of post-transcriptional gene regulation will be essential to gain a full understanding of the organization, function, and evolution of the human genome. The health relatedness of this application reflects the extensive involvement of RNA-processing dysfunction in numerous genetic diseases, neurological and neuromuscular disorders, and cancer. PUBLIC HEALTH RELEVANCE The relevance of this application to public health reflects the extensive involvement of defects in RNA metabolism associated with many human genetic diseases, neurological and neuromuscular disorders, and cancer. In addition, elucidating the basic mechanisms of the steps of gene regulation that are the focus of this conference, will be essential to gain a full understanding of the organization, function, and evolution of the human genome.

描述（由申请人提供）：该提案要求对戈登的转录后基因监管生物学研究会议部分支持，该研究将于2008年6月29日至7月4日在缅因州沃特维尔的科尔比学院举行。该会议是每隔一年举行的戈登会议系列的第三届会议。会议的广泛和长期目标是提高我们目前对正常和疾病状态中RNA生物发生的调节的理解。重点是涉及mRNA的转录后交易，但这扩展到转录耦合，以及涉及翻译及其对照的因素，包括tRNA和microRNA。这次会议的具体目的是召集大约45位代表转录后基因监管关键领域的发言人，共有150名参与者参加为期五天的会议。该计划将包括九个早晨或晚上的会议，这些课程将在：转录和RNA处理之间的耦合中广泛解决尖端问题； RNA处理信号和因素的基因组学和进化； RNA剪接催化，保真度，调节和参与疾病； RNA更新，包括胡说八道介导的mRNA衰减； RNA运输和定位；非编码RNA；和翻译控制。此外，四个下午的小型海报会议将使所有参与者能够为这些主题做出贡献并了解这些主题。在相对孤立的Colby College的夏季环境中，免费的下午和晚些时候，将刺激来自美国和国外的既定和初级首席研究人员，博士后学员和研究生之间的富有成效的非正式讨论。该应用程序的意义在于，该GRC具有独特的格式，并汇集了一组研究人员，尽管有融合的兴趣，但仍有很少见面的机会。由此产生的讨论和交叉施肥将有助于定义关键领域以推动这一领域的前进。此外，阐明转录后基因调节的基本机制对于获得人类基因组的组织，功能和进化至关重要。该应用的健康相关性反映了RNA处理功能障碍在许多遗传疾病，神经系统和神经肌肉疾病以及癌症中的广泛参与。公共卫生相关性与公共卫生的相关性反映了与许多人类遗传疾病，神经和神经肌肉疾病以及癌症相关的RNA代谢的广泛参与。此外，阐明基因调节步骤的基本机制，这是本次会议的重点，对于对人类基因组的组织，功能和进化的充分理解至关重要。