MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATION

真核转录调控机制

• 批准号: 6223591
• 负责人: Beverly Marie Emerson
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-12 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6223591
• 关键词: RNA biosynthesis; eukaryote; genetic transcription; meeting /conference /symposium; messenger RNA; travel

DESCRIPTION (taken from the application) The applicant requests partial support for the Keystone Conference on "Mechanisms of Eukaryotic Transcriptional Regulation" to be held during Feb. 26-Mar. 4, 2001 in Santa Fe, NM. The purpose of holding a meeting at this time is to bring together leading scientists and promising young investigators to present their latest findings in the rapidly moving and increasingly multidisciplinary field of transcriptional regulation. The control of gene expression is a multi-step process that involves modulation of chromatin structure to facilitate the interaction of RNA polymerase and transcription factors with the DNA template as well as direct regulation of polymerase during the preinitiation, initiation, and elongation stages of transcription. Recently, high-resolution crystallographic and NMR structures of the nucleosome, RNA polymerase, and complexes that regulate transcriptional activation, elongation, and histone acetylation have been determined. The information from these structural studies, together with ongoing biochemical analyses of transcriptional initiation and elongation, are providing an ever-clearer picture of the molecular interactions underlying transcriptional control. Additionally, the discovery and subsequent characterization of protein complexes and enzymatic activities that function as chromatin remodeling machines, co-activators, co-repressors, or mediators of transcription factors are unraveling many of the sophisticated regulatory mechanisms that integrate physiological signals within higher organisms. Important new information is also being generated concerning gene control at the chromosomal level and by changes in nuclear localization. Moreover, whole genome analysis is providing new insight into transcriptional regulatory circuitry at the cellular and organismal levels. Taken together, the information presented at this conference has direct relevance to our understanding of aberrant control mechanisms that underlie many human diseases. The focus of this meeting is to examine each major level of transcriptional regulation in detail and develop a coherent understanding of how specificity of gene expression is achieved in a chromosomal and a physiological context. Participation at this meeting should be of particular importance to the careers of graduate students and postdoctoral fellows hoping to specialize in this area of research.

描述（取自应用程序） 申请人要求部分支持基斯通会议 2月将在2月举行的“真核转录调节机制”。 26-MAR。 4，2001在新墨西哥州圣达菲。目前举行会议的目的 是将领先的科学家和有前途的年轻调查员聚集在一起 在快速移动和越来越多地提出他们的最新发现 转录调节的多学科领域。基因的控制 表达是一个多步骤过程，涉及调节染色质 促进RNA聚合酶与转录的相互作用的结构 DNA模板以及在聚合酶直接调节过程中的因素 转录的前启动，启动和伸长阶段。 最近，高分辨率的晶体学和NMR结构 调节转录的核小体，RNA聚合酶和复合物 已经确定了激活，伸长和组蛋白乙酰化。这 这些结构研究的信息以及持续的生化 转录启动和伸长的分析正在提供 转录基础分子相互作用的不断清除图 控制。另外，蛋白质的发现和后续表征 功能充当染色质重塑的复合物和酶活性 机器，共激活因子，共抑制剂或转录因子的介体 正在揭示许多整合的复杂调节机制 较高生物体中的生理信号。重要的新信息是 还会在染色体水平和通过 核定位的变化。此外，整个基因组分析正在提供 对细胞和转录调节电路的新见解 生物水平。综上所述，本次会议上提供的信息 与我们对异常控制机制的理解直接相关 基于许多人类疾病。这次会议的重点是检查每个 详细的主要转录调节级别并开发连贯 了解如何在A中实现基因表达的特异性 染色体和生理环境。参加这次会议应该 对于研究生的职业和 希望专门研究这一研究领域的博士后研究员。