MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATION

真核转录调控机制

• 批准号: 6223591
• 负责人: Beverly Marie Emerson
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-12 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6223591
• 关键词: RNA biosynthesis; eukaryote; genetic transcription; meeting /conference /symposium; messenger RNA; travel

DESCRIPTION (taken from the application) The applicant requests partial support for the Keystone Conference on "Mechanisms of Eukaryotic Transcriptional Regulation" to be held during Feb. 26-Mar. 4, 2001 in Santa Fe, NM. The purpose of holding a meeting at this time is to bring together leading scientists and promising young investigators to present their latest findings in the rapidly moving and increasingly multidisciplinary field of transcriptional regulation. The control of gene expression is a multi-step process that involves modulation of chromatin structure to facilitate the interaction of RNA polymerase and transcription factors with the DNA template as well as direct regulation of polymerase during the preinitiation, initiation, and elongation stages of transcription. Recently, high-resolution crystallographic and NMR structures of the nucleosome, RNA polymerase, and complexes that regulate transcriptional activation, elongation, and histone acetylation have been determined. The information from these structural studies, together with ongoing biochemical analyses of transcriptional initiation and elongation, are providing an ever-clearer picture of the molecular interactions underlying transcriptional control. Additionally, the discovery and subsequent characterization of protein complexes and enzymatic activities that function as chromatin remodeling machines, co-activators, co-repressors, or mediators of transcription factors are unraveling many of the sophisticated regulatory mechanisms that integrate physiological signals within higher organisms. Important new information is also being generated concerning gene control at the chromosomal level and by changes in nuclear localization. Moreover, whole genome analysis is providing new insight into transcriptional regulatory circuitry at the cellular and organismal levels. Taken together, the information presented at this conference has direct relevance to our understanding of aberrant control mechanisms that underlie many human diseases. The focus of this meeting is to examine each major level of transcriptional regulation in detail and develop a coherent understanding of how specificity of gene expression is achieved in a chromosomal and a physiological context. Participation at this meeting should be of particular importance to the careers of graduate students and postdoctoral fellows hoping to specialize in this area of research.

描述（摘自申请表） 申请人请求对 Keystone 会议提供部分支持 “真核转录调控机制”将于2月举行 3 月 26 日。 2001 年 2 月 4 日，新墨西哥州圣达菲。此时召开会议的目的 是汇集领先的科学家和有前途的年轻研究人员 展示他们在快速发展且日益增长的领域的最新发现 转录调控的多学科领域。基因的控制 表达是一个多步骤过程，涉及染色质的调节 促进RNA聚合酶和转录相互作用的结构 DNA模板的因素以及聚合酶的直接调节 转录的前起始阶段、起始阶段和延伸阶段。 最近，高分辨率晶体学和核磁共振结构 核小体、RNA聚合酶和调节转录的复合物 激活、延伸和组蛋白乙酰化已被确定。这 来自这些结构研究的信息，以及正在进行的生化研究 转录起始和延伸的分析提供了 转录分子相互作用的更清晰图景 控制。此外，蛋白质的发现和随后的表征 起到染色质重塑作用的复合物和酶活性 转录因子的机器、共激活子、共抑制子或介体 正在解开许多复杂的监管机制，这些机制将 高等生物体内的生理信号。重要的新信息是 还产生了有关染色体水平上的基因控制的信息 核定位的变化。此外，全基因组分析还提供 对细胞和转录调控电路的新见解 有机体水平。总而言之，本次会议上提供的信息 与我们对异常控制机制的理解有直接关系 是许多人类疾病的根源。这次会议的重点是审查每一个 主要水平的转录调控细节并制定连贯的 了解基因表达的特异性是如何在 染色体和生理背景。参加本次会议应 对研究生的职业生涯特别重要 希望专门从事这一研究领域的博士后研究员。