PLANT SELECTION, COLLECTION AND PROJECT DATA MANAGEMENT

工厂选择、收集和项目数据管理

• 批准号: 6102636
• 负责人: NORMAN R FARNSWORTH
• 金额: $ 1.43万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6102636
• 关键词: antineoplastics; biological products; chemical registry /resource; cooperative study; drug design /synthesis /production; information system analysis; information systems; literature survey; medicinal plants; plant extracts; plants; species difference; systematic biology

Program 1 will provide the plant material that the Consortium will need. This plant material will be selected on the basis of three strategies. The first strategy identifies species previously determined active in an experimental system similar to one or more of the present consortial assays, but in which no active agent has been identified. According to the second strategy, we will accept species in any genus that has been identified previously in a collector's manual of acceptable species. Third, our collaborating collectors may bring plants to our attention that they feel deserve examination and are not excluded in the collector's manual. All material will be received, verified, cataloged and milled by Program 1 before being sent to Program 2 for extraction. Program 1 will also provide an information management capacity for the data that will be generated over the course of the entire consortial effort. All information generated by Programs 1-5 will be collected by this program for inclusion in this database. This information will be redistributed to Programs 2-5 in the form of a number of different reports at regular intervals. In addition, the data will be available to all members of the consortial effort as raw data in a relational data structure. As such it will be possible for the data to be viewed from any perspective under any set of criteria. It is felt that with proper data management, trends or patterns may be found that will increase the overall efficiency and effectiveness of the effort. This program will provide a significant measure of literature or informational support to the fractionation and bioassay teams. information support will be provided at three points in the project, prior to the initial biological screen, during activity-guided chromatographic fractionation and, for active plant samples, an indepth retrospective analysis will be provided prior to a decision being made on recollection.

计划 1 将提供联盟所需的植物材料。 这种植物材料将根据三种策略进行选择。 第一个策略是识别先前确定的活跃物种 类似于当前联盟的一个或多个实验系统 化验，但其中尚未鉴定出活性剂。根据 第二个策略，我们将接受任何属的物种 先前在可接受物种的收藏手册中确定的。 第三，我们的合作收藏家可能会让植物引起我们的注意 他们认为值得检查并且不被排除在外 收藏家手册。所有材料将被接收、验证、编目 并通过程序 1 进行研磨，然后发送到程序 2 进行提取。 计划 1 还将提供信息管理能力 将在整个联盟过程中生成的数据 努力。计划 1-5 生成的所有信息将由 该程序包含在该数据库中。该信息将被 以许多不同的形式重新分配给计划 2-5 定期报告。此外，数据将可供 联盟所有成员的努力作为关系数据中的原始数据 结构。因此，可以从任何位置查看数据 在任何一套标准下的观点。感觉只要有正确的数据 可能会发现管理、趋势或模式，从而增加 工作的总体效率和效果。 该计划将提供重要的文献或 为分离和生物测定团队提供信息支持。 将在该项目的三个点提供信息支持， 在初始生物筛选之前，在活动指导期间 色谱分离，对于活性植物样品，进行深入的分析 在做出决定之前将提供回顾性分析 就回忆而言。