Botanical Dietary Supplements for Women's Health

促进女性健康的植物膳食补充剂

• 批准号: 6910585
• 负责人: NORMAN R FARNSWORTH
• 金额: $ 100万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6910585
• 关键词: alternative medicine; clinical research; dietary supplements; drug discovery /isolation; drug screening /evaluation; phytoestrogens; plant extracts; women' s health

The UIC/NIH Center for Botanical Dietary Supplements Research was established in the fall of 1999 to address the issues of standardization, quality, safety, and efficacy of botanical dietary supplements. The Center then adopted and will continue to implement a multidisciplinary strategy to achieve its basic and clinical research objectives. Participating faculty Co-investigators and collaborators are drawn from the Departments of Medicinal Chemistry and Pharmacognosy and Biopharmaceutical Sciences in the College of Pharmacy; the Department of Medicine (Section of Endocrinology and Metabolism) in the College of Medicine; and the Department of Math, Statistics, and Computer Science in the College of Liberal Arts. The Center studies botanicals with potential benefits for women's health, focusing on plants that are reported to alleviate the symptoms of menopause and premenstrual syndrome. Botanical extracts are subjected to rigorous chemical evaluation followed by both in vitro and in vivo biological testing. Standardized botanical extracts that appear efficacious and demonstrate adequate safety profiles in in vitro and animal models will be candidates for clinical, Phase I trials. Hops (Humulus lupulus L.) will undergo Phase I evaluation in this grant cycle. In order to achieve this comprehensive agenda for the development of chemically- and biologically-standardized botanical dietary supplements, the renewed BRC research program will be organized around three Projects, supported by two Cores: Project by Farnsworth, Standardization of Botanicals; Project by Bolton, Mechanism of Action of Botanicals (Menopause); Project by van Breemen, Studies of Metabolism, Bioavailability, and Toxicity; Administration and Development Core and Analytical Core. The administration and Development Core will administer two additional programs: a Pilot Project Program and a Training and Career Development Program. The experiments proposed in this application will greatly enhance our understanding of the mechanism of action of botanicals and whether they are safe and efficacious for women's health.

UIC/NIH 植物膳食补充剂研究中心成立于 1999 年秋季，旨在解决植物膳食补充剂的标准化、质量、安全性和功效问题。该中心随后采取并将继续实施多学科战略，以实现其基础和临床研究目标。参与研究人员和合作者来自药学院药物化学系、生药学系和生物制药科学系；医学院医学系（内分泌与代谢科）；以及文学院的数学、统计和计算机科学系。该中心研究对女性健康具有潜在益处的植物，重点关注据报道可以缓解更年期和经前综合症症状的植物。植物提取物经过严格的化学评估，然后进行体外和体内生物学测试。标准化植物 在体外和动物模型中表现出有效并证明足够安全性的提取物将成为临床 I 期试验的候选者。啤酒花（Humulus lupulus L.）将在本资助周期中进行第一阶段评估。为了实现开发化学和生物标准化植物膳食补充剂的全面议程，新的 BRC 研究计划将围绕三个项目进行组织，并得到两个核心的支持：Farnsworth 项目，植物药标准化；博尔顿的项目，机制 植物药的作用（更年期）； van Breemen 的项目，代谢、生物利用度和毒性研究；管理和开发核心以及分析核心。 行政和发展核​​心将管理另外两个计划：试点项目计划和培训和职业发展计划。本文提出的实验 应用将大大增强我们对植物药作用机制及其对女性健康是否安全有效的了解。