Epigenetic inheritance: how does it work?

表观遗传：它是如何运作的？

• 批准号: FT180100653
• 负责人: A/Prof Alyson Ashe
• 金额: $ 53.86万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-14 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT180100653
• 关键词: Epigenetic; inheritance; how; does; work

This project aims to determine the mechanisms responsible for the inheritance of acquired traits. Sometimes the environment can have effects on the phenotype of not only the exposed individual, but also their children and grandchildren. While it is clear that this can occur, what is not clear is the mechanism by which this happens and the frequency at which it happens. This project will use the model organism Caenorhabditis elegans, innovative new techniques for the discovery of low abundance RNA molecules, and fluorescence microscopy to analyse structures within the cell nucleus to determine what the molecular mechanism is by which this "transgenerational epigenetic inheritance" occurs. This will have an impact on evolutionary theory, as well as long-term consequences for the understanding of human health and disease, and the impact of a changing climate on agriculture.

该项目旨在确定负责获得特征的继承的机制。有时，环境不仅会影响暴露的人的表型，而且还会影响其子孙。虽然很明显，但尚不清楚发生这种情况的机制及其发生的频率。该项目将使用秀丽隐杆线虫的模型生物体，创新的新技术来发现低丰度RNA分子和荧光显微镜来分析细胞核内的结构，以确定这种分子机制是什么，而这种“转基因表观遗传遗传”发生。这将对进化论产生影响，以及对人类健康和疾病的理解以及气候变化对农业的影响的长期影响。