Discovering the molecular controls of epigenetic inheritance

发现表观遗传的分子控制

• 批准号: DP240100725
• 负责人: A/Prof Alyson Ashe
• 金额: $ 48.73万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100725
• 关键词: Discovering; molecular; controls; epigenetic; inheritance

This project aims to investigate the way in which acquired traits can be inherited. The environment that an individual is exposed to can change the characteristics of not only that individual, but also their children and grandchildren. We do not yet understand the mechanisms by which this “epigenetic inheritance” occurs. Using interdisciplinary approaches, this project combines the power of the model organism Caenorhabditis elegans with cutting-edge single molecule microscopy techniques to determine the molecular mechanisms by which the environment can impact future generations. This should ultimately provide society with the means to harness the power of epigenetics.

该项目旨在调查可以继承获得的特征的方式。一个人接触的环境不仅可以改变该个人的特征，还可以改变其子女和孙子的特征。我们尚不了解这种“表观遗传遗传”的机制。使用跨学科方法，该项目将秀丽隐杆线虫模型的力量与尖端的单分子显微镜技术结合在一起，以确定环境可以影响未来后代的分子机制。这最终应该为社会提供利用表观遗传学的力量的手段。