ULTRASONIC SAFETY AND THERAPY IN OPHTHALMOLOGY

眼科超声安全和治疗

• 批准号: 2888439
• 负责人: Ernest Joseph Feleppa
• 金额: $ 30.93万
• 依托单位: RIVERSIDE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2888439
• 关键词: athymic mouse; bioimaging /biomedical imaging; biological models; biomedical equipment development; computer simulation; diagnosis design /evaluation; diagnosis procedure safety; eye disorder diagnosis; eye neoplasms; eye surgery; laboratory rabbit; miniature swine; neoplasm /cancer therapy; noninvasive diagnosis; ultrasonography; ultrasound biological effect; ultrasound therapy

This research program combines biomedical engineering efforts at Riverside Research Institute (RRI) and biological and medical investigations at Cornell University Medical College (CUMC). The ultimate objectives of the research are: 1) to develop reliable ultrasonic techniques for treating ocular tumors that threaten life and sight; and 2) to assure the safe use of promising new diagnostic ultrasound techniques that promise perhaps revolutionary advances for combatting ocular diseases. Both objectives involve comprehensive, scientific investigations of how ultrasonic energy modifies tissue. Therapy investigations involve the development of intense, short-term ultrasound exposures to treat tumors before blood-flow cooling and attendant uncertainties become significant. Special ultrasound transducers will be developed to reliably induce asymmetric lesions for producing efficient lesion matrices that cover extensive tumor volumes. A comprehensive computer simulation provides a model of relevant beam propagation and tissue heating. In-vivo ultrasonic spectrum analysis techniques and 3-D scanning are used together with histopathology and biologic assays to characterize induced in-vivo changes in human tumor explants. Remote temperature estimations are also being investigated. Safety studies involve ultrasonic pulsed Doppler exposures of the eye, with particular attention to the potential for thermal damage in the absorptive, avascular ocular lens. Very-high-frequency ultrasound systems, which can resolve fine-scale microstructures (e.g., 30-microM dimensions), are also under study; these systems apply frequencies (e.g., 50 MHz and above) that are much higher than those previously used in biological-effects experiments. The combined use of these systems with contrast agents will also be investigated from a safety perspective. Safety will be experimentally investigated by employing these techniques in animal eyes with comprehensive follow-up examinations. A theoretical model for safety will be established. These studies are intended to identify procedures and design criteria needed to support the continued development and safe use of modern ultrasonic capabilities. This program will result in a comprehensive data base and a validated model of ultrasonic effects for extrapolating results to humans. The model will also provide fundamental information regarding non-invasive tumor therapy and diagnostic safety for a broad spectrum of medical applications.

该研究计划结合了河边的生物医学工程工作 研究所（RRI）以及生物学和医学调查 康奈尔大学医学院（CUMC）。 最终目标 研究是：1）开发可靠的超声技术治疗 威胁生命和视力的眼部肿瘤； 2）确保安全使用 有希望的新诊断超声技术，也许有望 抗击眼疾病的革命进步。 这两个目标 涉及对超声能量的全面科学研究 修饰组织。 治疗调查涉及强烈的短期发展 超声暴露于血液冷却之前治疗肿瘤和 随之而来的不确定性变得重要。 特殊超声 将开发换能器以可靠地诱导不对称病变 产生有效的病变矩阵，覆盖了广泛的肿瘤量。 全面的计算机模拟提供了相关光束的模型 传播和组织加热。 体内超声频谱分析 技术和3-D扫描与组织病理学一起使用和 生物学测定以表征人类肿瘤的诱导体内变化 epplants。 还正在研究远程温度估计。 安全研究涉及超声波脉冲多普勒的眼睛暴露， 特别注意在 吸收性的无血管眼镜。 非常高的超声 系统，可以解决细节微观结构（例如30毫克 维度），也正在研究中；这些系统应用频率（例如， 50 MHz及以上），比以前使用的高度高得多 生物效应实验。 这些系统的结合使用与 对比剂也将从安全角度进行调查。 安全将通过使用这些技术来实验研究 在动物眼中进行全面的随访检查。 理论 将建立安全模型。 这些研究旨在 确定支持持续所需的程序和设计标准 开发和安全使用现代超声波功能。 该程序将导致全面的数据库和经过验证的 超声效应的模型，将结果推送到人类。 这 模型还将提供有关非侵入性的基本信息 广泛医学的肿瘤疗法和诊断安全 申请。