MEASURING DEPENDENCE AND WITHDRAWAL IN TEEN SMOKERS

衡量青少年吸烟者的依赖和戒断情况

• 批准号: 2896751
• 负责人: SUZANNE M COLBY
• 金额: $ 21.06万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-25 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2896751
• 关键词: adolescence (12-20); attention; behavior prediction; caloric dietary content; clinical research; cognition; cues; drug withdrawal; heart rate; human subject; hunger; memory; motivation; neuropsychological tests; nicotine; outcomes research; performance; psychometrics; psychomotor reaction time; smoking; smoking cessation; tobacco abuse

DESCRIPTION: (Applicant's Description) Tobacco smoking by adolescents poses a major health threat, with 90% of adults having initiated smoking before the age of 18. Research with chronic adult smokers has demonstrated certain aversive effects of nicotine abstinence which have been implicated in maintenance of smoking among adults. Little is known about the characteristics, intensity, or relevance of nicotine withdrawal among adolescent smokers. The primary objective of this research is to measure the physiological and psychological characteristics of nicotine withdrawal among adolescent smokers and to assess the relevance of these measures in predicting subsequent difficulty quitting smoking. In the proposed study, adolescent smokers (ages 13-17) will be recruited from a primary care setting to participate in a 3-session experimental protocol designed to assess nicotine withdrawal under carefully controlled laboratory conditions. Measures will include: a cognitive performance computerized test battery, negative affect and reactive irritability, smoking cue reactivity, and caloric intake. During session I, baseline assessments will be completed with no deprivation from nicotine. During session 2, assessments will be repeated after overnight abstinence from nicotine. In session 3, assessments will be re-administered after participants have resumed smoking at their baseline level. Immediately following session 3, a brief smoking intervention will be delivered. Follow-up assessments will occur in person at 3 and 6 months later, to measure smoking outcome. Measures of nicotine withdrawal effects (changes from session 1 to 2) and withdrawal relief effects (changes from session 2 to 3) will be evaluated and validated against: (1) baseline measures of tobacco use history, current intake levels, nicotine dependence, and motivation to quit smoking; and (2) subsequent tobacco use and quit attempts at follow up. A pilot study is proposed for Year 1 of this application in order to determine the cognitive performance test battery components to use in the larger trial. This research will contribute the first: 1) assessment of withdrawal among adolescents that is not retrospective or subjective; 2) evaluation of objective withdrawal characteristics among abstaining adolescents under controlled conditions; and 3) prospective validation of withdrawal measures as they relate to subsequent smoking outcomes. Thus, it will provide a greater understanding of nicotine withdrawal as a maintaining factor of adolescent smoking, and thereby provide an empirical basis for enhancing smoking cessation approaches for youth.

描述：（申请人的描述）青少年吸烟烟草姿势吸烟 主要的健康威胁，有90％的成年人以前开始吸烟 18岁。与慢性成年吸烟者的研究证明了某些 尼古丁节制的厌恶作用已与 维持成人吸烟。 关于 尼古丁提取的特征，强度或相关性 青春期吸烟者。 这项研究的主要目的是衡量 尼古丁提取的生理和心理特征 在青少年吸烟者中，并评估这些措施的相关性 预测随后戒烟的困难。 在拟议的研究中 青少年吸烟者（13-17岁）将从初级保健中招募 设置参与旨在的三项实验协议 在精心控制的实验室条件下评估尼古丁戒断。 措施将包括：认知性能计算机测试电池， 负面影响和反应性易怒，吸烟提示反应性和 热量摄入。 在第一节期间，基线评估将完成 没有尼古丁的剥夺。 在第2节期间，评估将是 尼古丁过夜禁欲后重复。 在会议3中， 参与者恢复吸烟后，评估将重新管理 在他们的基线水平。 第3届会议之后，立即抽烟 干预将进行。 后续评估将亲自进行 在3个和6个月后，以测量吸烟结果。 尼古丁的度量 提款效果（从第1节更改为2）和提款缓解 效果（从第2节更改为3）将进行评估和验证 反对：（1）烟草使用历史的基线测量，当前摄入量 水平，尼古丁的依赖性以及戒烟的动机； （2） 随后的烟草使用和退出后续尝试。 试点研究是 为了确定认知，建议该应用程序的第一年 性能测试电池组件将在较大的试验中使用。 这 研究将贡献第一个：1）评估退出的评估 不是回顾性或主观的青少年； 2）评估 避免青少年的客观提款特征 受控条件； 3）预先验证提款措施 因为它们与随后的吸烟结果有关。 因此，它将提供 对尼古丁戒断的更深入的了解为维护因素 青少年吸烟，从而为增强的经验基础 青年戒烟方法。