BIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAME

马达加斯加和苏里南的生物多样性利用

• 批准号: 6078342
• 负责人: DAVID GEORGE IAN KINGSTON
• 金额: $ 61.4万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6078342
• 关键词: Africa; South America; alternative medicine; angiogenesis inhibitors; antibiotics; antifungal agents; antiinfective agents; antimalarial agents; antineoplastics; antitubercular agents; antiviral agents; bioassay; chemical structure; cooperative study; drug design /synthesis /production; drug discovery /isolation; drug screening /evaluation; ethnic group; field study; folk medicine; hot climate; information dissemination; international cooperation; medicinal plants; pesticides; plant ecology; plant extracts; training; tropical medicine; workshop

The overall goals of this International Cooperative Biodiversity group are to achieve the threefold mission of biodiversity conservation, economic development and drug discovery in the countries of Suriname and Madagascar. The proposed research integrates the work of seven different associate programs into a coherent whole to achieve these goals. In Suriname plants will be collected primarily by teams from Conservation International, with some recollections being done by botanists from Missouri Botanic Garden (MBG). The plants will be extracted by workers at the Surinamese company Bedrijf Geneesmiddelen Voorziening Suriname (BGVS) and then bioassays for both pharmaceutical and agrochemical activity will be carried out BGVS, a Bristol-Myers Squibb Pharmaceutic Research Institute (BMS), at Virginia Polytechnic Institute and State University (VPISU) and at DowElanco. Activities of interest include antibacterial, anti-cancer, anti-mycobacterial, anti-malarial, anti-fungal, cardiovascular, CNS, and anti-viral activities in the pharmaceutical area, and insecticidal and anti-fungal activities in the agrochemical area. Active extracts will be fractionated and the structures of active compounds determined at BGVS, VPISU, or BMS, depending on the activity found. Compounds with novel structure and/or novel activities that are of interest for drug development will be patented and subjected to further testing at BMS or DowElanco, depending on the activity. Royalties will be paid to Suriname on sales of compounds that proceed to clinical or agrochemical use. In Madagascar, plants will be collected primarily by botanists from Missouri Botanical Garden (MBG), with simultaneous ethnobotanical work being carried out by teams from Conservation International. The plants will be extracted by workers at the Centre National d'Application et des Recherches Pharmaceutiques (CNARP). Subsequent bioassays, fractionation studies, and chemistry will be carried out by CNARP, BMS, DowElanco, and VPISU, in the interest areas described above, and royalties will be paid to Madagascar on sales of any pharmaceuticals or agrochemicals that are developed from this work. In addition to the drug discovery work outlined above, the Group will also carry out economic development and biodiversity conservation initiative in both Suriname and Madagascar. In Suriname the work will include documentation of traditional ethnobotanical knowledge and training in both modern systems such as GIS and in traditional knowledge through the "Shaman's Apprentice" program. In Madagascar the work will include the completion of biodiversity surveys of well-defined forest preserves, as well as training in botanical methods at Missouri Botanical Garden.

该国际生物多样性合作组织的总体目标是 实现生物多样性保护、经济发展的三重使命 苏里南和其他国家的开发和药物发现 马达加斯加。拟议的研究整合了七个不同的工作 将计划整合为一个连贯的整体以实现这些目标。 在苏里南，植物将主要由保护团队收集 国际，一些回忆是由植物学家完成的 密苏里植物园 (MBG)。这些植物将由工人在 苏里南公司 Bedrijf Geneesmiddelen Voorziening 苏里南 (BGVS) 然后对药物和农业化学活性进行生物测定 进行 BGVS，一项百时美施贵宝制药研究 弗吉尼亚理工学院暨州立大学研究所 (BMS) (VPISU) 和 DowElanco。感兴趣的活动包括抗菌、 抗癌、抗分枝杆菌、抗疟疾、抗真菌、 制药领域的心血管、中枢神经系统和抗病毒活性， 以及农化领域的杀虫和抗真菌活动。 活性提取物将被分馏并且活性的结构 在 BGVS、VPISU 或 BMS 中确定的化合物，具体取决于活性 成立。具有新颖结构和/或新颖活性的化合物 药物开发的兴趣将获得专利并受到进一步的保护 根据活动，在 BMS 或 DowElanco 进行测试。版税将是 向苏里南支付销售进入临床或临床阶段的化合物的费用 农用化学品的使用。 在马达加斯加，植物将主要由植物学家从 密苏里植物园 (MBG)，同时开展民族植物学工作 由保护国际组织的团队进行。植物 将由国家应用和设计中心的工作人员提取 制药研究中心 (CNARP)。随后的生物测定、分级分离 研究和化学将由 CNARP、BMS、DowElanco 和 VPISU，在上述利益领域，将支付特许权使用费 向马达加斯加销售任何符合以下条件的药品或农用化学品： 从这项工作发展而来。 除上述药物发现工作外，集团还将 开展经济发展和生物多样性保护行动 苏里南和马达加斯加。在苏里南的工作将包括 传统民族植物学知识的记录和培训 现代系统（例如地理信息系统）和传统知识 《萨满的学徒》节目。在马达加斯加的工作将包括 完成对明确界定的森林保护区的生物多样性调查， 以及密苏里植物园的植物学方法培训。