BIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAME

马达加斯加和苏里南的生物多样性利用

• 批准号: 2722192
• 负责人: DAVID GEORGE IAN KINGSTON
• 金额: $ 61.3万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2722192
• 关键词: Africa; South America; alternative medicine; angiogenesis inhibitors; antibiotics; antifungal agents; antiinfective agents; antimalarial agents; antineoplastics; antitubercular agents; antiviral agents; bioassay; chemical structure; cooperative study; drug design /synthesis /production; drug screening /evaluation; ethnic group; field study; folk medicine; hot climate; information dissemination; international cooperation; medicinal plants; pesticides; plant ecology; plant extracts; training; tropical medicine; workshop

The overall goals of this International Cooperative Biodiversity group are to achieve the threefold mission of biodiversity conservation, economic development and drug discovery in the countries of Suriname and Madagascar. The proposed research integrates the work of seven different associate programs into a coherent whole to achieve these goals. In Suriname plants will be collected primarily by teams from Conservation International, with some recollections being done by botanists from Missouri Botanic Garden (MBG). The plants will be extracted by workers at the Surinamese company Bedrijf Geneesmiddelen Voorziening Suriname (BGVS) and then bioassays for both pharmaceutical and agrochemical activity will be carried out BGVS, a Bristol-Myers Squibb Pharmaceutic Research Institute (BMS), at Virginia Polytechnic Institute and State University (VPISU) and at DowElanco. Activities of interest include antibacterial, anti-cancer, anti-mycobacterial, anti-malarial, anti-fungal, cardiovascular, CNS, and anti-viral activities in the pharmaceutical area, and insecticidal and anti-fungal activities in the agrochemical area. Active extracts will be fractionated and the structures of active compounds determined at BGVS, VPISU, or BMS, depending on the activity found. Compounds with novel structure and/or novel activities that are of interest for drug development will be patented and subjected to further testing at BMS or DowElanco, depending on the activity. Royalties will be paid to Suriname on sales of compounds that proceed to clinical or agrochemical use. In Madagascar, plants will be collected primarily by botanists from Missouri Botanical Garden (MBG), with simultaneous ethnobotanical work being carried out by teams from Conservation International. The plants will be extracted by workers at the Centre National d'Application et des Recherches Pharmaceutiques (CNARP). Subsequent bioassays, fractionation studies, and chemistry will be carried out by CNARP, BMS, DowElanco, and VPISU, in the interest areas described above, and royalties will be paid to Madagascar on sales of any pharmaceuticals or agrochemicals that are developed from this work. In addition to the drug discovery work outlined above, the Group will also carry out economic development and biodiversity conservation initiative in both Suriname and Madagascar. In Suriname the work will include documentation of traditional ethnobotanical knowledge and training in both modern systems such as GIS and in traditional knowledge through the "Shaman's Apprentice" program. In Madagascar the work will include the completion of biodiversity surveys of well-defined forest preserves, as well as training in botanical methods at Missouri Botanical Garden.

这个国际合作生物多样性小组的总体目标是 为了实现生物多样性保护的三重任务，经济 苏里南国家的开发和药物发现 马达加斯加。拟议的研究整合了七个不同的工作 将计划与一个连贯的整体相关联，以实现这些目标。 在苏里南工厂将主要由保护团队收集 国际，植物学家正在做一些回忆。 密苏里植物园（MBG）。这些植物将由工人提取 Surinamese Company Bedrijf Geneesmiddelen Voorziening Suriname（BGVS） 然后，用于药物和农化活性的生物测定将 进行BGVS，BRISTOL MYERS SPORBB PHARMACETACITIC研究 弗吉尼亚理工学院和州立大学的研究所（BMS） （vpisu）和Dowelanco。感兴趣的活动包括抗菌， 抗癌，抗菌，抗疟疾，抗真菌， 药物区域的心血管，中枢神经系统和抗病毒活动， 以及农业化学区域的杀虫和抗真菌活性。 活性提取物将被分馏，并且有效的结构 根据活性，在BGV，VPISU或BMS上确定的化合物 成立。具有新颖结构和/或新型活动的化合物 对药物开发的兴趣将获得专利，并进一步进行 根据活动在BMS或Dowelanco进行测试。特许权使用费 支付给苏里南的销售临床或 农业化学用途。 在马达加斯加，植物将主要由植物学家收集 密苏里植物园（MBG），同时进行民族植物学工作 由国际自然保护区团队进行。植物 将由中心国家申请中心的工人提取 Recherches Pharmaceutiques（CNARP）。随后的生物测定，分馏 研究和化学将由CNARP，BMS，Dowelanco和 VPISU，在上述利息领域，并将支付特许权使用费 到马达加斯加的任何药品或农业化学物质的销售 从这项工作开发。 除了上面概述的药物发现外，该小组还将 执行经济发展和生物多样性保护计划 苏里南和马达加斯加。在苏里南，工作将包括 传统民族植物学知识和培训的文献 通过GIS等现代系统和传统知识通过 “萨满的学徒”计划。在马达加斯加的工作将包括 完成定义明确的森林蜜饯的生物多样性调查，如 以及密苏里植物园植物学方法的培训。