OPTIMIZING HIV/TB MANAGEMENT IN THE HAART ERA

HAART 时代优化 HIV/TB 管理

基本信息

批准号：
7497217
负责人：
Gail Shor-Posner
金额：
$ 9.57万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-24 至 2009-05-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7497217
关键词：
AIDS Dementia Complex AIDS clinical trial group AIDS prevention AIDS/HIV problem Academic degree Accounting Achievement Acquired Immunodeficiency Syndrome Adam11 gene Address Adherence Admission activity Adolescent Adult Affect Africa Africa South of the Sahara Age-Years Alabama Alcohols Ambulatory Care Facilities American Americas Anti-Retroviral Agents Antitubercular Agents Appendix Area Argentina Arts Attention Authorization documentation Award Awareness Bacteria Behavior Therapy Behavioral Behavioral Research Behavioral Sciences Bioethics Brain Brazil Breast Feeding CCL22 gene CD4 Lymphocyte Count Calmette-Guerin Bacillus Caribbean natives Caribbean region Caring Cause of Death Centers for Disease Control and Prevention (U.S.)Child Child Care Childbirth Childhood Cities Clinic Clinical Clinical Nurse Specialists Clinical Research Clinical Sciences Clinical Services Clinical Trials Cognitive Collaborations Colombia Combined Modality Therapy Commit Communicable Diseases Communities Complement Complementary therapies Complex Comprehensive Health Care Country Dentists Depth Detection Deterioration Developed Countries Developing Countries Development Diagnosis Diagnostic Discipline of obstetrics Disclosure Discrimination Disease Disease Management Disease Progression Disease Resistance Doctor of Philosophy Dominican Dominican Republic Drug Addiction Drug Interactions Drug abuse Drug resistance Drug user Economics Education Educational process of instructing Educational workshop Effectiveness Effectiveness of Interventions Environment Epidemic Epidemiology Ethics Evaluation Exhibits Face Faculty Female Adolescents Florida Fostering Foundations Functional disorder Funding Future Gender Genetic Genotype Genus Mycobacterium Goals Government Grant Guyana HIV HIV Infections HIV Seropositivity HIV-1 HIV-1 vaccine Haiti Head Health Health Personnel Health Policy Health Professional Health Services Health Services Accessibility Health education Healthcare Heterosexuals High Prevalence Highly Active Antiretroviral Therapy Home environment Honduras Hospitalization Hospitals Human Human Resources Human Rights Human Virology Immune Immune system Immunologic Monitoring Immunology Improve Access Incidence Indigenous Individual Infant Infection Information and Communication Theory Institutes Institution Instruction International International AIDS Internet Intervention Investigation Jamaica Joints Journals Knowledge Laboratories Laboratory Research Laboratory Technicians Lantana Last Name Latin America Leadership Letters Life Lipodystrophy Local Government Malaria Maryland Massage Medical Medical center Medicine Mental Health Services Mental disorders Methods Microbiology Minority Modeling Molecular Biology Mothers Names National Center for Complementary and Alternative Medicine National Institute of Allergy and Infectious Disease National Institute of Child Health and Human Development National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Nebraska Needs Assessment Neurocognitive Neurosecretory Systems New York Newsletter Numbers Nurses Nutritional Nutritionist Observational Study Operations Research Orphan Outcome Palliative Care Pan American Health Organization Parenting behavior Patients Pattern Pediatric Hospitals Pediatrics Perception Perinatal Personal Satisfaction Persons Peru Pharmaceutical Preparations Pharmacists Pharmacologic Substance Physicians Placebo Control Policy Maker Population Population Growth Positioning Attribute Postdoctoral Fellow Postpartum Period Poverty Predisposition Pregnant Women Prevalence Prevention Prevention Research Prevention education Prevention intervention Prevention program Prevention strategy Primary Health Care Principal Investigator Printing Procedures Process Programmed Learning Provider Psychiatry Psychologist Psychology, Other Public Health Public Health Education Public Health Schools Public Policy Publications Quality of life RNA Interference Race Range Rate Readiness Recreational Drugs Reporting Research Research Activity Research Ethics Research Infrastructure Research Methodology Research Project Grants Research Training Resistance Resources Risk Risk Factors Risk Reduction Role Rotation Ruthenium Ben Scientist Secondary Prevention Sentinel Services Sex Behavior Signal Transduction Site Social Aspects of Cancer Social Impacts Source Stigmata Stigmatization Stress Structure Substance abuse problem Support System Suriname Technology Terminal Disease Testing Today Toxic effect Training Training Activity Training Programs Training Support Training in Biomedical and Behavioral Research Tuberculosis USAID Uganda United Nations United States United States National Institutes of Health Universities University Hospitals Vaccination Vaccines Vertical Disease Transmission Vision Vulnerable Populations West Indies Woman Wood material Work World Bank Writing abstracting antiretroviral therapy biopsychosocial burden of illness care burden chlorambucil/dactinomycin/methotrexate protocol cohort coping cost day design disease natural history disorder control disorder prevention experience feeding group counseling health care service utilization health economics high risk behavior high risk sexual behavior immune function improved interest international center intervention program medical schools men men who have sex with men migration mortality multidisciplinary mycobacterial pandemic disease pediatric AIDS prenatal programs psychologic psychological stressor psychosocial research study response size skills social stigma sound stress management success symposium therapeutic vaccine tool transmission process treatment program tuberculosis drugs tuberculosis treatment vaccine development

项目摘要

Approximately 93% of the global HIV infections occur in the developing world, with Latin America accounting for 1.5 million cases and the Caribbean, which has the highest HIV prevalence rate outside of sub-Saharan Africa, for 440,00 more, indicating the critical need for an international effort to control HIV spread in these countries. Through the auspices of the Miami Fogarty AITRP and Pediatric programs, 175 government- endorsed scholars have received instruction in AIDS/TB prevention and treatment, returning home (92+% return rate) to guide their countries with initiatives and strategies to reduce the burden of disease. With the advent of highly active antiretroviral therapy (HAART), possibilities of HIV-1 suppression and control have emerged. In response to increasing access to HAART in Latin America and the Caribbean our objectives for the next five years are designed to promote independent and sustainable scientific capacity that will enable Fogarty scholars to assist their countries in conducting wide-scale programs to: 1) Promote optimal treatment and care of children and adults living with HIV/AIDS and those co-infected with HIVFI'B; 2) Enhance adherence for HIV/TB treatment, and reduce the potential for drug resistance; 3) Determine obstacles in access to care, including the impact of stigma on utilization of health services; 4) Identify continued high-risk behaviors and establish appropriate interventions to reduce risk of transmission, and improve quality of life in the era of HAART; and 5) Evaluate the economic and social impact of prevention and treatment interventions. The establishment of effective scientific infrastructures, and long-standing partnerships between Miami and host- country institutions will permit the challenges facing our target countries (Brazil, Colombia, Dominican Republic, Guyana, Jamaica, Peru) to be addressed. These objectives will be implemented in the context of ethical procedures and will include attention to the economic and social impact of research operations. We propose to integrate the research expertise of our in-country Fogarty scholars with biomedical and behavioral research training, according to the specific needs of the host countries. Research training will be conducted in Miami and the host countries, to facilitate independent research capacity and sustainable interventions, to ultimately quell the tide of the epidemic. PERFORMANCESITE(S) (organization, city, state) Division of Disease Prevention Department of Psychiatry and Behavioral Sciences University of Miami School of Medicine KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Shor-Posner, Gall, PhD University of Miami-School of Medicine Ashkin, David, MD A.G. Holley State Tuberculosis Hospital Goodman, Kenneth, PhD University of Miami-School of Medicine McCoy, Clyde, PhD University of Miami-School of Medicine Miguez-Burbano, Maria Jose, PhD, MD University of Miami-School of Medicine Mitchell, Charles, MD University of Miami-School of Medicine Scott, Gwendolyn, MD University of Miami-School of Medicine Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] No PHS 398 (Rev. 05/01 Page 2 shown below. Role on Project Principal Investigator Director, TB Director, Ethics Director, Research Co-PI Co-PI Director, Pediatrics Form Page 2 PrincipInavl estigator/PrDoigreracmt(oLarst, first, middle):Shor-Posner,G. The name of the principal investigatodprogram director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Face Page .................................................................................................................................................. Description,

大约93％的全球艾滋病毒感染发生在发展中国家，拉丁美洲会计对于150万例案件和加勒比海地区，撒哈拉以外的艾滋病毒患病率最高非洲，更多440,00，这表明对控制艾滋病毒传播的国际努力至关重要国家。通过迈阿密Fogarty AITRP和小儿计划的主持人，175个政府认可的学者已收到有关艾滋病/结核病预防和治疗的指导，返回家园（92+％回报率）指导其国家采用倡议和策略来减轻疾病负担。与高度活跃的抗逆转录病毒疗法（HAART）的出现，HIV-1抑制和控制的可能性具有出现了。为了响应增加拉丁美洲的Haart的访问权限和加勒比海的访问权限接下来的五年旨在促进独立和可持续的科学能力，这将使 Fogarty学者协助其国家开展广泛的计划：1）促进最佳治疗以及对艾滋病毒/艾滋病的儿童和成人以及与Hivfi'b共同感染的儿童和成人； 2）提高依从性用于HIV/TB治疗，并降低耐药性的潜力； 3）确定获得护理的障碍，包括污名对卫生服务利用的影响； 4）确定持续的高风险行为和建立适当的干预措施，以减少传播风险，并改善时代的生活质量哈特5）评估预防和治疗干预措施的经济和社会影响。这建立有效的科学基础设施以及迈阿密与主人之间的长期合作伙伴关系 - 国家机构将允许我们的目标国家（巴西，哥伦比亚，多米尼加）面临的挑战共和国，圭亚那，牙买加，秘鲁）要解决。这些目标将在道德程序，并将关注研究行动的经济和社会影响。我们建议将我们的国内福加蒂学者与生物医学和行为的研究专业知识相结合根据东道国的特定需求，研究培训。研究培训将在迈阿密和东道国，促进独立的研究能力和可持续干预措施，以最终平息了流行病的潮流。表演场（S）（组织，城市，州）预防疾病精神病学和行为科学系迈阿密大学医学院关键人员。请参阅说明。根据需要使用延续页面，以格式提供所需的信息从首席研究员开始。按字母顺序列出所有其他关键人员，首先姓氏。名称组织 Shor-Posner，Gall，迈阿密学院医学院博士 Ashkin，David，MD A.G. Holley State结核病医院古德曼，肯尼思，迈阿密大学医学院博士麦考伊，克莱德，迈阿密学院医学博士 Miguez-Burbano，Maria Jose，PhD，医学博士迈阿密大学医学院米切尔（Mitchell），查尔斯（Charles），医学博士迈阿密大学医学院斯科特（Scott）披露许可声明。仅适用于SBIR/STTR。请参阅说明。 []是[]否 PHS 398（修订版05/01 Page 2 如下所示。项目的角色首席研究员结核病主任道德董事研究主任 Co-Pi Co-Pi 儿科主任表2 princioninavl estigator/prdoigreracmt（olst，第一，中间）：shor-posner，g。必须在每个打印页面的顶部和每个延续页面的顶部提供主要的调查程序主管的名称。研究赠款目录面页.................................................................................................................................................................................................................................................................................................... 描述，