EPIDEMIOLOGY OF RECURRENT SEXUALLY TRANSMITTED INFECTION IN ADOLESCENTS

青少年复发性性传播感染的流行病学

• 批准号: 6099520
• 负责人: DONALD P ORR
• 金额: --
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6099520
• 关键词: Chlamydia trachomatis; Neisseria gonorrhoeae; Trichomonas vaginalis; adolescence (12-20); behavioral /social science research tag; condoms; contraceptives; cooperative study; disease /disorder prevention /control; disease /disorder proneness /risk; epidemiology; female; health behavior; human subject; interpersonal relations; longitudinal human study; microorganism culture; self concept; sex behavior; sex partner; sexually transmitted diseases; socioeconomics; socioenvironment; spermicide; substance abuse related disorder

Sexually transmitted infections (STI) are important causes of morbidity among American adolescents. Recurrent infections with N. gonorrhoeae, C. trachomatis and T. vaginalis are common; reinfection increases the risk of morbidity and thus contributes importantly to the public health burden of sexual transmitted disease. STI among adolescents take place within the context of psychosocial development, self-protective behaviors, social environment and sexual interpersonal relationships but these contexts are given inadequate attention in traditional epidemiologic models and interventions to reduce STI. Supported by social-psychological theory, adolescent behavioral research, and extensive clinical experience with sexually active adolescents, the proposed research is intended to expand current understanding of the behavioral epidemiology of recurrent sexually transmitted infections among adolescents by careful exploration of the central role of protective behaviors within the context of sexual interpersonal relationships and partner change characteristics. The Specific Aims are to: 1) Describe behavioral, interpersonal and organism- specific factors associated with risk of recurrent STI in adolescent males and females; 2) Assess actors associated with the timing of recurrent infections to test the specific hypothesis that early (within 6 months of initial infection) recurrences are more likely to occur in the setting of an ongoing sexual relationship, and that late (more than 6 months after initial infection) recurrence is more likely to occur in the setting of new sexual partners. We will enroll and follow for 15 months a cohort of 600 high risk males and females, 14-19 year old, with STI (N. gonorrhoeae, C trachomatis, and T. vaginalis) obtaining trimonthly serial behavioral measures and genitourinary tract cultures. As related to the timing of subsequent infection(s), we will determine the variations in and patterns of accrual of sexual partnerships (with special attention to the duration, pattern and rate of change of relationships), the inter- and intra-personal factors which underlie these patterns, the interrelationships among behaviors which modify risk for STI (health protective vs health endangering such as condom use, long-term monogamous relationship, substance use) and the association of social environment with recurrent STI. Framed within Self-Efficacy Theory, the results of this behavioral epidemiologic study of high risk adolescents will be directly relevant to future interventions to reduce recurrent STI among high risk adolescents.

性传播感染（STI）是发病率的重要原因 在美国青少年中。 C. Gonorrhoeae的复发感染。 沙眼和阴道T.很常见；再感染增加了 发病率，因此对公共卫生负担重要 性传播疾病。青少年中的STI发生在 社会心理发展，自我保护行为，社会的背景 环境和人际关系，但这些背景是 在传统的流行病学模型中给予了不充分的关注和 减少STI的干预措施。在社会心理学理论的支持下， 青少年行为研究和广泛的临床经验 性活跃的青少年，拟议的研究旨在扩大 当前对重复性行为行为流行病学的理解 通过仔细探索对青少年的传播感染 保护行为在性行为中的核心作用 人际关系和伴侣改变特征。这 具体目的是：1）描述行为，人际和生物 - 与青少年男性反复发生的STI风险相关的特定因素 和女性； 2）评估与经常性时间相关的参与者 感染以检验早期的特定假设（在6个月内 初始感染）复发更有可能在 持续的性关系，迟到（超过6个月 初始感染）在设置的情况下更可能发生复发 新的性伴侣。 我们将注册并关注15个月的队列600个高风险男性 和女性，14-19岁 T.阴道）获得三个序列行为措施和 泌尿生殖道培养。与随后的时间有关 感染，我们将确定应计的变化和模式 性伙伴关系（特别关注持续时间，模式 人际关系的变化率），人际关系内和个人内部 这些模式的基础的因素，以及之间的相互关系 改变STI风险的行为（健康保护与健康 危害避孕套，长期一夫一妻关系等危害 物质使用）和社会环境与经常性的关联 STI。 在自我效能理论中构建了这种行为的结果 高风险青少年的流行病学研究将与 未来的干预措施，以减少高风险青少年的反复性传播感染。