MID AMERICA ADOLESCENT STD COOPERATIVE RESEARCH CENTER

中美洲青少年性病合作研究中心

• 批准号: 6373981
• 负责人: DONALD P ORR
• 金额: $ 153.88万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6373981
• 关键词: adolescence (12-20); female; sexually transmitted diseases

The purpose of the Mid-America Adolescent Sexually Transmitted Diseases Cooperative Research Center (MASTD CRC) is to conduct integrated, multidisciplinary research on important issues related to sexually transmitted infections in adolescents. The goal is to examine longitudinally the behavioral, psychosocial and biological risk and protective factors related to sexually transmitted infections of the lower genital tract among middle adolescent women. The five projects will be supported by an Administrative Core (A), a Clinical Core (B) data, a Laboratory Core (C) and Biostatistical Core (D). A behavioral epidemiology project will investigate the psychosocial (sociocultural and family, social/sexual networks, attitudes), partner-specific interpersonal relationship (relationship quality, communication), and coitus-specific (sexual interest, substance use) factors associated with risk and protection. Two projects will focus on organisms causing genital ulcer disease, cervicitis and PID. One will elucidate the nature of the interaction between the gonococcus and the cervical cell surface. The other will examine the relationships of omp1 genotype, immune factors and repeated lower genital tract chlamydia infections in adolescent women. The fourth project will explore the pathogenesis of human papillomavirus infections with emphasis on the controlling susceptibility to infection. The fifth project investigates important aspects of vaginal immunity as influenced by reproductive hormones and sexually transmitted pathogens (C. trachomatis, N. gonorrhoeae, T. vaginalis). The multi-disciplinary research conducted by this consortium agreement between Indian University and NorthWestern University, Louisiana State University and University of Iowa Schools of Medicine will increase out understanding of the complex interplay of actors that increase risk for and protected from STI. Real time video tele-conferencing will be used to facilitate collaboration, interchange of ideas and cross-disciplinary research across campuses. The findings from the studies conducted by the center investigators will facilitate intervention-oriented research for primary and secondary prevention of STD for adolescents.

中美洲青少年性传播疾病的目的 合作研究中心（MASTD CRC）将进行整合， 关于与性有关的重要问题的多学科研究 青少年传播感染。目标是检查 纵向行为，社会心理和生物学风险， 与较低的性传播感染有关的保护因素 青少年妇女中的生殖道。这五个项目将是 由行政核心（a），临床核心（b）数据支持，a 实验室核心（C）和生物统计核心（D）。行为流行病学 项目将调查社会心理（社会文化和家庭， 社交/性网络，态度），特定于合作伙伴的人际关系 关系（关系质量，沟通）和特定于COITUS （性利益，药物使用）与风险和风险相关的因素 保护。两个项目将重点放在引起生殖溃疡的生物上 疾病，宫颈炎和PID。一个人将阐明 淋球菌与宫颈细胞表面之间的相互作用。这 其他将研究OMP1基因型，免疫因子和 在青春期妇女中反复重复生殖道的衣原体感染。这 第四个项目将探索人乳头瘤病毒的发病机理 感染，重点是控制感染的敏感性。 第五个项目调查了阴道免疫的重要方面 受生殖激素和性传播病原体的影响（C. 沙眼，N。Gono​​rrhoeae，T。vaginalis）。多学科 印度大学之间该财团协议进行的研究 西北大学，路易斯安那州立大学和大学 爱荷华州医学院将增加对综合体的理解 参与者的相互作用会增加风险并受到STI的保护。真实的 时间视频电信会议将用于促进协作， 跨校园的思想和跨学科研究的互换。这 中心研究人员进行的研究结果将 促进以干预为导向的主要和次级研究 预防青少年的性病。