MID AMERICA ADOLESCENT STD COOPERATIVE RESEARCH CENTER

中美洲青少年性病合作研究中心

• 批准号: 6373981
• 负责人: DONALD P ORR
• 金额: $ 153.88万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6373981
• 关键词: adolescence (12-20); female; sexually transmitted diseases

The purpose of the Mid-America Adolescent Sexually Transmitted Diseases Cooperative Research Center (MASTD CRC) is to conduct integrated, multidisciplinary research on important issues related to sexually transmitted infections in adolescents. The goal is to examine longitudinally the behavioral, psychosocial and biological risk and protective factors related to sexually transmitted infections of the lower genital tract among middle adolescent women. The five projects will be supported by an Administrative Core (A), a Clinical Core (B) data, a Laboratory Core (C) and Biostatistical Core (D). A behavioral epidemiology project will investigate the psychosocial (sociocultural and family, social/sexual networks, attitudes), partner-specific interpersonal relationship (relationship quality, communication), and coitus-specific (sexual interest, substance use) factors associated with risk and protection. Two projects will focus on organisms causing genital ulcer disease, cervicitis and PID. One will elucidate the nature of the interaction between the gonococcus and the cervical cell surface. The other will examine the relationships of omp1 genotype, immune factors and repeated lower genital tract chlamydia infections in adolescent women. The fourth project will explore the pathogenesis of human papillomavirus infections with emphasis on the controlling susceptibility to infection. The fifth project investigates important aspects of vaginal immunity as influenced by reproductive hormones and sexually transmitted pathogens (C. trachomatis, N. gonorrhoeae, T. vaginalis). The multi-disciplinary research conducted by this consortium agreement between Indian University and NorthWestern University, Louisiana State University and University of Iowa Schools of Medicine will increase out understanding of the complex interplay of actors that increase risk for and protected from STI. Real time video tele-conferencing will be used to facilitate collaboration, interchange of ideas and cross-disciplinary research across campuses. The findings from the studies conducted by the center investigators will facilitate intervention-oriented research for primary and secondary prevention of STD for adolescents.

中美洲青少年性传播疾病的目的 合作研究中心（MASTD CRC）将进行综合、 与性有关的重要问题的多学科研究 青少年传播感染。目标是检查 纵向的行为、心理社会和生物风险 与下层性传播感染相关的保护因素 中期青春期女性的生殖道。这五个项目将 由管理核心 (A)、临床核心 (B) 数据、 实验室核心 (C) 和生物统计核心 (D)。行为流行病学 项目将调查社会心理（社会文化和家庭、 社交/性网络、态度）、特定伴侣的人际关系 关系（关系质量、沟通）和特定性交 （性兴趣、物质使用）与风险相关的因素和 保护。两个项目将重点关注引起生殖器溃疡的微生物 疾病、宫颈炎和PID。人们将阐明这一现象的本质 淋球菌和宫颈细胞表面之间的相互作用。这 其他将检查 omp1 基因型、免疫因素和 青春期女性反复下生殖道衣原体感染。这 第四个项目将探索人乳头瘤病毒的发病机制 感染，重点是控制感染的易感性。 第五个项目调查阴道免疫的重要方面： 受生殖激素和性传播病原体的影响（C. 沙眼衣原体、淋病奈瑟菌、阴道毛滴虫）。多学科 由印度大学之间的联盟协议进行的研究 和西北大学、路易斯安那州立大学和路易斯安那大学 爱荷华州医学院将增加对该综合体的了解 增加性传播感染风险并免受性传播感染影响的因素之间的相互作用。真实的 时间视频电话会议将用于促进协作， 跨校园的思想交流和跨学科研究。这 中心研究人员进行的研究结果将 促进中小学以干预为导向的研究 预防青少年性病。