EARLY LEARNING EFFECTS ON ADULT NEUROENDOCRINE SYSTEM

早期学习对成人神经内分泌系统的影响

• 批准号: 2640424
• 负责人: SCOTT A MACDOUGAL-SHACKLETON
• 金额: $ 2.62万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2640424
• 关键词: behavioral /social science research tag; bioperiodicity; early experience; ethology; gonadotropin releasing factor; hormone regulation /control mechanism; hypothalamic pituitary axis; immunocytochemistry; mature animal; neuroendocrine system; ovary; pituitary gonadal axis; radioimmunoassay; reproductive development; sex behavior; songbirds; vocalization

DESCRIPTION (adapted from applicant's abstract): This study will examine the effects of early learning on the adult neuroendocrine system. Specifically, it will examine the physiological and behavioral response of female white-crowned sparrows (Zonotrichia leucophrys oriantha) to male songs with which they have, or have not, had prior experience. White-crowned sparrows learn their songs during a sensitive phase early in life, but respond to these songs in adulthood. Juvenile females sparrows will be captured from their natal area and housed in captivity. Then they will be stimulated by long days and played back male courtship songs from either their natal area or another area. Songs from another species and no song will be used as control treatments. Behavioral responses to be examined will be nest-building and solicitation displays. Physiological responses to be examined will include ovarian development and circulating hormone levels. Photoperiodic species of birds exhibit remarkable plasticity in the size and number of neurons immunoreactive for gonadotropin releasing hormone (GnRH), and changes in this system will also be measured. Hormone levels will be determined by radioimmunoassay. Immunoreactive GnRH neurons will be measured by immunocytochemistry. These experiments will test two hypotheses: i) that young female white-crowned sparrows imprint on the song of their natal area, and that in adulthood this learned song facilities both reproductive behavior and neuroendocrine responses to photo-period; ii) that this physiological response to song is mediated directly by the hypothalamo-pituitary-gonad axis.

描述（根据申请人的摘要改编）：本研究将检查 早期学习对成人神经内分泌系统的影响。 具体而言，它将检查 雌性白冠麻雀（Zonotrichia leucophrys oriantha） 他们拥有或没有的歌曲具有先前的经验。 白冠麻雀在早期的敏感阶段学习了他们的歌曲 生活，但在成年后回应这些歌曲。 少年女性麻雀 将从他们的出生区域捕获并被囚禁。 然后他们 将受到漫长的日子的刺激，并从 他们的出生区域或其他区域。 来自另一个物种的歌曲，没有 歌曲将被用作控制治疗。 行为反应是 检查的将是筑巢和招标显示。 生理 进行检查的响应将包括卵巢开发和循环 激素水平。 光周期的鸟类表现出色 促性腺激素免疫反应的大小和数量的可塑性 释放激素（GNRH）以及该系统的变化也将进行测量。 激素水平将由放射免疫测定法确定。 免疫反应性GNRH 神经元将通过免疫细胞化学测量。 这些实验会 测试两个假设：i）那个年轻的女性白冠麻雀印在上面 他们出生区的歌曲，以及成年后的歌曲 繁殖行为和神经内分泌的反应 照片周期； ii）这种对歌曲的生理反应是介导的 直接通过下丘脑 - 垂体 - 基纳德轴。