Subcortical Visual System Development

皮层下视觉系统开发

• 批准号: 6529001
• 负责人: JENNIFER R PRICHARD
• 金额: $ 2.57万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-05 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6529001
• 关键词: albino rat; behavioral /social science research tag; bioperiodicity; circadian rhythms; developmental neurobiology; early experience; electroencephalography; electromyography; immunocytochemistry; neuroanatomy; neurophysiology; nonvisual photoreceptor; photobiology; photostimulus; predoctoral investigator; retinal adaptation; sleep; sleep regulatory center; stereotaxic techniques; visual cortex; visual deprivation; visual perception; visual stimulus

DESCRIPTION (provided by applicant): Exposure to atypical lighting conditions, like chronic darkness, during a critical period in development causes long-lasting deficits in the anatomy and function of the image forming visual system. Surprisingly, little is known about how abnormal lighting schedules affect the anatomy and function of the non-image forming visual system, a collection of subcortical retinorecipient nuclei. These nuclei mediate a variety of immediate and long-term light-responsive behaviors including sleep, circadian rhythms, visual attention, and pupillary constriction. We hypothesize that exposure to abnormal lighting schedules during early development will adversely affect the anatomy and function of sleep-wakefulness centers in the non-image forming visual system and may impair the ability of light-detecting neural networks to coordinate behavioral and physiological responses to light. To test this hypothesis, we will rear litters of albino rats in either constant light or constant dark from birth until adulthood. We will then use anterograde tracing to examine the connectivity of retinofugal fibers to subcortical targets (SA 1), use immediate early gene expression to analyze the molecular response of these neurons to acute light-dark shifts (SA 2), and use activity chambers and sleep recording electrodes to document sleep and circadian rhythms in response to light (SA3). Results from these studies will provide a first comprehensive analysis of the effects of light- and dark-rearing on sleep-wakefulness anatomy and function. Ultimately, a greater understanding of how early exposure to lighting schedules affects the developing sleep and circadian systems should provide insight into etiology of several sleep and circadian disorders.

描述（由申请人提供）：暴露于非典型照明条件， 像慢性黑暗一样，在开发的关键时期 图像形成视觉的解剖结构和功能的持久缺陷 系统。令人惊讶的是，关于光线安排如何异常了解 影响非图像形成视觉系统的解剖结构和功能 皮层视网膜分离核的收集。这些核介导A 多种直接和长期的光响应行为，包括睡眠， 昼夜节律，视觉注意力和瞳孔收缩。我们假设 早期开发过程中这种暴露于异常照明时间表将 不利地影响睡眠清除中心的解剖结构和功能 非图像形成视觉系统，可能会损害光检测的能力 神经网络以协调对光的行为和生理反应。 为了检验这一假设，我们将以常数为单位的白化大鼠的垃圾 从出生到成年后的光线或恒定的黑暗。然后，我们将使用直行 追踪以检查视网膜纤维与皮层的连通性 靶标（SA 1），使用立即的早期基因表达来分析分子 这些神经元对急性浅黑色偏移（SA 2）的反应，并使用活动 室和睡眠记录电极以记录睡眠和昼夜节律 响应光（SA3）。这些研究的结果将提供第一个 对光和黑暗锻炼的影响的全面分析 睡眠消除解剖学和功能。最终，对 早期暴露于照明时间表如何影响发展中的睡眠和 昼夜节律系统应洞悉几种睡眠的病因和 昼夜节律。