PHYSIOLOGY OF INDIVIDUAL DISCRIMINATION/RECOGNITION

个人歧视/认可的生理学

• 批准号: 2708713
• 负责人: ARAS T PETRULIS
• 金额: $ 2.5万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-11 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2708713
• 关键词: association learning; behavior test; behavioral /social science research tag; behavioral habituation /sensitization; electrodes; electroencephalography; entorhinal cortex; hamsters; hippocampus; lateral olfactory area; learning transfer; memory; neural information processing; olfactory stimulus; sensory discrimination; stereotaxic techniques

DESCRIPTION (Adapted from applicant's abstract): The major objective of this proposal is to understand how different olfactory recipient areas of the hamster brain participate in learning and storing odor information about other individual hamsters. This will be done by analyzing the coding properties of single neurons and ensembles of neurons in olfactory cortex, entorhinal cortex and hippocampus while hamsters perform two types of individual discrimination recognition tasks that differ in their processing demands. The first test is a basic habituation discrimination task in which hamsters are repeatedly presented with odors from one individual hamster and are then presented with another animal's odor. Hamsters form and maintain some memory of different individuals' odors over long periods of time as evidenced by habituation of investigation to one odor and increased investigation of the new individual's odor. The second task is a variation on this paradigm in which hamsters are allowed to interact with two individuals (A & B) for several days and are then habituated to one particular odor from A and then tested with another particular odor from A. Behaviorally, hamsters generalize their habituation to the second odor only if they have previously interacted with that animal, indicating that hamsters associate the two perceptually distinctive odors with each other and that they come to represent the individual hamster. This latter test provides an opportunity to test the hypothesis that the hippocampal system is involved in the formation of declarative (conscious, relational and flexible) memories, but not procedural (unconscious, inflexible, and limited) memories by predicting that only hippocampal neurons will code this odor-odor relationship. In contrast, social odor memories formed in the first task are non-relational and are therefore not predicted to require hippocampal coding but will be represented in olfactory and entorhinal cortex activity. This proposal is part of a broader research program that uses rodent species as experimental models of human amnesia with the explicit intent of characterizing the neural structures involved in human memory formation.

描述（根据申请人的摘要改编）： 该建议是了解不同的嗅觉接收者领域 仓鼠大脑参与学习和存储有关的气味信息 其他个人仓鼠。 这将通过分析编码来完成 嗅觉皮质中神经元的单个神经元的特性， 仓鼠进行两种类型 其处理不同的个人歧视识别任务 需求。 第一个测试是一项基本的习惯歧视任务 仓鼠反复出现了一个仓鼠的气味， 然后出现另一只动物的气味。 仓鼠形成并保持 长期以来对不同个体的气味的一些记忆 调查习惯对一种气味并增加了 调查新人的气味。 第二个任务是变体 在这个范式上，允许仓鼠与两个相互作用 个人（A＆B）几天，然后习惯于一个 A的特殊气味，然后用A。 从行为上讲，仓鼠只将其习惯概括为第二种气味 如果他们以前与该动物互动，表明 仓鼠将两种知名异常的气味相关联 他们来代表个人仓鼠。 后一个测试 提供了测试海马系统的假设的机会 参与声明性的形成（有意识，关系和 灵活的记忆，但不是程序性的（无意识，僵化和 有限的记忆通过预测只有海马神经元才能编码 气味关系。 相反，在 第一个任务是非关系的，因此不预测需要 海马编码，但将以嗅觉和内性为代表 皮层活动。 该建议是更广泛的研究计划的一部分 将啮齿动物物种用作人类健忘症的实验模型 明确表征人类涉及的神经结构的意图 内存形成。