HORMONAL INFLUENCES ON NEURAL-BEHAVIORAL DEVELOPMENT

荷尔蒙对神经行为发育的影响

• 批准号: 2668573
• 负责人: Melissa Hines
• 金额: $ 12.86万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2668573
• 关键词: androgens; behavioral /social science research tag; child psychology; clinical research; cognition; congenital adrenal hyperplasia; developmental neurobiology; embryo /fetus toxicology; female; gender difference; hormone regulation /control mechanism; human subject; male; mathematical ability; neural information processing; neuropsychological tests; neuropsychology; preference; self concept; space perception; verbal learning

DESCRIPTION: The role of androgen in the development of cognitive function and neural organization will be evaluated by studying patients with congenital adrenal hyperplasia (CAH), an autosomal recessive disorder causing increased androgen production beginning prenatally. One hundred fifty patients (50 male and 50 female) will be compared to unaffected relatives and to demographically-matched controls. Abilities to be assessed include visuospatial abilities, mathematical abilities, verbal abilities, targeting abilities and general intelligence. Manifestations of neural organization to be assessed include hand preferences and language lateralization. Three competing hypotheses regarding the relationship of prenatal androgen to cognition will be evaluated: 1. Androgen promotes cognitive abilities at which males excel on average (mathematical problem solving, mental rotations abilities, spatial perception and targeting) and impairs those at which female excel on average (verbal fluency and perceptual speed and accuracy); 2. Androgen is associated with general intellectual enhancement; and 3. Androgen is associated with discrepancies between verbal and performance intelligence that have been interpreted to suggest learning disabilities. Hypotheses that prenatal androgen exposure is associated with masculine- typical patterns of neural organization, reflected in reduced right hand preferences and increased language lateralization, will also be assessed. Finally, structural equation models will be used to examine relationships between sex-typed activities in childhood and subsequent patterns of neural organization and cognitive function.

描述：雄激素在发育中的作用 认知功能和神经组织的 通过研究先天性肾上腺的患者评估 增生（CAH），一种常染色体隐性疾病，导致疾病 从产前开始增加雄激素的产生。 一百五十 将患者（50名男性和50名女性）与未受影响的患者进行比较 亲戚和人口统计学匹配的控件。 能力 评估包括视觉空间能力，数学能力，口头 能力，定位能力和一般情报。 表现 待评估的神经组织包括手偏好和 语言横向化。 关于产前关系的三个竞争假设 将评估雄激素到认知： 1。雄激素促进了雄性脱颖而出的认知能力 平均（数学问题解决，心理旋转能力， 空间感知和靶向），并损害女性 平均表现出色（语言流利度和感知速度和准确性）； 2。雄激素与一般智力增强有关；和 3。雄激素与言语和语言之间的差异有关 绩效智能被解释为建议学习 残疾。 假设产前雄激素暴露与男性有关 神经组织的典型模式，右手减少反映 偏好和语言横向化的增加也将被评估。 最后，结构方程模型将用于检查关系 在童年时期的性活动和随后的模式之间 神经组织和认知功能。