VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN

绝经后黑人女性补充维生素 D

• 批准号: 2769406
• 负责人: JERI WANZOR NIEVES
• 金额: $ 10.28万
• 依托单位: HELEN HAYES HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769406
• 关键词: 1,25 dihydroxycholecalciferol; 25 hydroxycholecalciferol; African American; aging; blood chemistry; bone density; bone fracture; bone metabolism; calcium metabolism; clinical research; clinical trials; dietary supplements; female; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; interview; longitudinal human study; nutrition related tag; osteoporosis; outcomes research; pathologic bone resorption; photon absorptiometry; placebos; polymerase chain reaction; postmenopause; questionnaires; statistics /biometry; urinalysis; vitamin D; vitamin D deficiency; vitamin D receptors; vitamin receptor; vitamin therapy; women's health

Osteoporosis is a major public health problem throughout the world. Although black women are believed to be at lower risk of osteoporotic fracture than white women, the risk of fracture in postmenopausal black women is still substantial. Blacks have consistently lower 25- hydroxy-vitamin D levels and an elevation in parathyroid hormone level compared to white women. These findings are consistent with vitamin D insufficiency, or in some, true deficiency. Vitamin D insufficiency has been implicated in bone loss with aging in the white female population. furthermore, in white elderly women and men, treatment with vitamin D has resulted in a lower rate of bone loss and fractures. The effect of vitamin D supplementation has never been evaluated in black women. We hypothesize that the presence of relative 25(OH)D insufficiency that exists among black postmenopausal women may exacerbate loss of bone among aging black women. To test this hypothesis, we propose to conduct a randomized clinical trial to compare vitamin D supplementation (1000 IU/ day) with placebo during a two year study in a population of 150 black postmenopausal (>5 years) women, who are shown to be 25(OH)D insufficient. We propose to determine whether supplemental vitamin D (1000 IU) improves mineral metabolism, increases calcium absorption, reduces bone turnover and reduces the rate of bone loss in black postmenopausal women. In addition, we intend to determine whether biochemical and bone density responses to vitamin D supplementation in black women are related to allelic variation in the vitamin D receptor. The fact that black women fracture less frequently than white woman and tend to have higher bone mass has virtually excluded this ethnic group from studies of osteoporosis treatment and prevention. However, the fracture rate in black women is still substantial. It is possible that a simple, safe nutritional supplement, vitamin D, could reduce the rate of bone loss and risk of osteoporotic fracture in black women.

骨质疏松症是全球一个主要的公共卫生问题。 尽管据信黑人妇女的骨质疏松风险较低 骨折比白人妇女，绝经后骨折的风险 黑人妇女仍然很重要。黑人始终降低25-- 羟基 - 维生素D水平和甲状旁腺激素的升高 与白人妇女相比。这些发现与 维生素D功能不全，或者在某些缺乏症中。维生素d 与白色的衰老有关，与骨质流失有关 女性人口。此外，在白人老年男女中， 用维生素D治疗导致骨质流失率较低，并且 断裂。维生素D补充的作用从未有过 在黑人妇女中进行评估。我们假设存在 相对25（OH）D不足，黑色 绝经后妇女可能加剧衰老的骨骼损失 黑人妇女。为了检验这一假设，我们建议进行 比较补充维生素D的随机临床试验（1000 IU/ DAY）与安慰剂一起进行两年的研究，人口为150 黑人绝经后（> 5岁）的女性，被证明是 25（OH）D不足。我们建议确定是否补充 维生素D（1000 IU）改善矿物质代谢，增加钙 吸收，减少骨骼更新并降低骨质流失率 黑色绝经后妇女。 此外，我们打算确定 生化和骨密度对维生素D的反应是否 黑人妇女补充与等位基因变异有关 维生素D受体。黑人妇女骨折的频率较低的事实 比白人妇女几乎具有更高的骨头 从骨质疏松治疗的研究和 预防。但是，黑人妇女的骨折率仍然 重大的。一种简单，安全的营养补品可能是 维生素D可以降低骨质流失和骨质疏松的风险 黑人妇女骨折。