VITAMIN D AND BONE STATUS IN THE ELDERLY

老年人的维生素 D 和骨骼状况

• 批准号: 6233983
• 负责人: MICHAEL F HOLICK
• 金额: $ 10.07万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6233983
• 关键词: 1,25 dihydroxycholecalciferol; 25 hydroxycholecalciferol; African American; Asian Americans; Hispanic Americans; alkaline phosphatase; bone density; caucasian American; clinical trials; dietary supplements; frail elderly; human old age (65+); human subject; lighting; longitudinal human study; nutrition of aging; nutrition related tag; parathyroid hormones; seasons; solar radiation; ultraviolet radiation; ultraviolet therapy; vitamin D; vitamin D deficiency; vitamin metabolism

It is well recognized that exposure to sunlight is absolutely essential for the development and maintenance of a healthy skeleton in humans when dietary sources of vitamin D are not adequate. Radiation of wavelengths less than 316 nm initiates the production of vitamin D in human skin, a deficiency of which is now being recognized as a health problem amongst the elderly both in Europe and the United States. Sunlight contains a small component of the biologically active UVB wavelengths required for cutaneous vitamin D synthesis and for a generally mobile individual, a normal lifestyle provides sufficient sunlight exposure to maintain a healthy vitamin-D status. However, age is known to decrease the amount of vitamin-D precursor in the skin, and this, together with the lack of outdoor activity undertaken by the elderly and infirm, leads to the bone diseases associated with vitamin-D deficiency. To combat this problem, we need to know how much sunlight exposure throughout the year is required for health. The latter quantity is a function not only of time, but also of skin area exposed, season, and latitude. This study will assess the affect of aging on cutaneous vitamin D synthesis in vivo by monitoring the natural UVB exposure and vitamin-D status of volunteers in a well defined population of elderly in a nursing home setting. Comparison of the (a) solar spectrum with the spectrum with the spectra of fluorescent lights and (b) the capacity of fluorescent lighting to promote cutaneous previtamin D3 synthesis will then enable recommendations to be made for the use of solar irradiation as a means of maintaining adequate vitamin-D nutrition for the elderly mobile residents and for the possible development of UVB-enhanced lighting that could be used in hospital wards and nursing homes for infirm patients who are susceptible to vitamin-D deficiency and cannot go outdoors.

众所周知，暴露于阳光绝对是必不可少的 为了开发和维护人类健康的骨骼 维生素D的饮食来源不足。 波长的辐射 小于316 nm启动了人类皮肤中维生素D的产生，一个 现在的缺乏症已被认为是健康问题 欧洲和美国的老年人。 阳光包含一个 生物活性UVB波长的小部分 皮肤维生素D合成，对于通常流动的个体， 正常的生活方式可提供足够的阳光暴露以维持 健康的维生素-D状态。 但是，已知年龄会减少数量 皮肤中的维生素-D前体的 老年人和体弱的户外活动导致骨骼 与维生素-D缺乏症相关的疾病。 要解决这个问题， 我们需要知道全年的阳光暴露是多少 健康需要。 后一个数量不仅是时间的函数， 而且皮肤面积暴露，季节和纬度。 这项研究会 评估衰老对体内皮肤维生素D合成的影响 监测志愿者的天然UVB暴露和维生素-D状态 在疗养院环境中，有明确的老年人人口。 （a）太阳光谱与光谱的比较 荧光灯和（b）荧光照明的能力 然后促进皮肤前预防D3合成将启用 建议使用太阳辐射作为一种手段 为老年移动居民维持足够的维生素-D营养 以及可能开发UVB增强照明的可能是 用于医院病房和疗养院 容易受到维生素-D缺乏症的影响，无法在户外进行。