CORE--NON-INVASIVE MEASUREMENT OF BONE MINERAL

核心——骨矿物质的无创测量

• 批准号: 6201522
• 负责人: JERI WANZOR NIEVES
• 金额: $ 13.97万
• 依托单位: HELEN HAYES HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6201522
• 关键词: biomedical facility; bone density; bone metabolism; noninvasive diagnosis

The bone mineral measurement core is necessary for the measurement of bone mass in both humans and in animals. The core has served the past two SCOR applications and has proven to be a cost effective mechanism of providing high precision measurements for 4 of the 5 projects proposed in this application. In Project 1, the vertebrae and femur of 24 transgenic mice will be measured in year 4. This core will be used to evaluate bone mass changes in mice and the excised bones from rats. In vivo measurements of L4-L6 vertebrae and the femur will be made 3 times per year in 80 live mice per year over the course of the experiment. Ex vivo samples of the femur and vertebrae in 65 rats each year will be measured by utilizing the DXA. Total sample measurements per year will be 580 scans. In Project 4, the cohort of 89 women with primary hyperparathyroidism will have bone mineral measurements at 3 skeletal sites (spine, hip, forearm) every 12 months to determine longitudinal changes in bone mass with medical treatment and following parathyroidectomy (total number of scans is 1068).This core will be used to compare the bone density response to hPTH 1-34 in estrogen deficient women, women on estrogen therapy and women in estrogen and placebo control groups. The bone density response to discontinuation and a later rechallenge of hPTH 1-34 will also be measured. Project 6 involves serial bone density measures (duplicate scans at baseline and every 6 months) at 5 skeletal sites (lumbar spine, hip, forearm, total body, and lateral spine) during the treatment, its' withdrawal and a later rechallenge. The total number of scans for all protocols in Project 6 is 4900. We have also incorporated into the core a feasibility study to determine whether micro-MRI can provide information equivalent to conventional histomorphometry and further improve the ability of bone mass to predict bone strength in the animal model. In addition to providing core support for the individual projects in this grant, the core has also been integral to the success of other NIH funded studies, at no additional cost to the SCOR grant.

骨矿物测量核心对于骨骼的测量是必需的 人类和动物中的质量。核心已经为过去两个得分服务 申请，已被证明是提供具有成本效益的机制 针对此提议的5个项目中的4个项目中的4个高精度测量 应用。在项目1中，24只转基因小鼠的椎骨和股骨 将在第4年进行测量。该核心将用于评估骨质量 小鼠和从大鼠切除的骨骼的变化。体内测量 L4-L6椎骨和股骨将在80 Live中每年进行3次 在实验过程中，每年小鼠。离体样本 每年将使用65只大鼠的股骨和椎骨。 DXA。每年的样本测量总数为580次扫描。在项目4中 89名患有原发性甲状旁腺功能亢进症的女性的队列将有骨头 每12个骨骼位点的矿物测量 用医学确定骨量的纵向变化的月份 治疗和甲状旁腺切除术后（扫描总数为 1068）。将使用该核心比较骨密度的响应与HPTH 1-34在雌激素缺乏女性中，女性接受雌激素治疗的妇女和女性 雌激素和安慰剂对照组。骨密度响应对 停产和后来的HPTH 1-34的补偿也将是 测量。项目6涉及串行骨密度度量（重复扫描 在基线和每6个月）处）在5个骨骼部位（腰椎，臀部， 治疗期间前臂，全身和侧脊），其' 退出和后来的补偿。所有人的扫描总数 项目6中的协议为4900。我们还将其合并到核心A中 可行性研究以确定Micro-MRI是否可以提供信息 等效于常规的组织形态法，并进一步改善 骨骼质量预测动物模型中骨骼强度的能力。在 除此之外为单个项目提供核心支持 格兰特（Grant），核心也是其他NIH资助的成功的组成部分 研究，无需支付SCOR赠款的额外费用。