EFFICIENCIES OF ENERGY TRANSDUCTION BY CYTOCHROME OXIDASE AND BACTERIORHODOPSIN

细胞色素氧化酶和细菌视紫红质的能量转换效率

• 批准号: 2576743
• 负责人: R W HENDLER
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2576743
• 关键词: bacteriorhodopsins; bioenergetics; cytochrome oxidase; fiber optics; liposomes; membrane reconstitution /synthesis; method development; oxidative phosphorylation; phospholipids; photochemistry

This project was put on "temporary hold" this past year so that the full efforts of the laboratory could be concentrated on the kinetic analyses of cytochrome aa3 (cox) and bacteriorhodopsin (BR) (HL00401-29 LCB). The decision to put all of our resources on the other project was based on the fact that very important developments occurred in both the cox and BR investigations that poised both of these pursuits for major developments which we felt it important to pursue immediately. In the coming year we will continue our work on the development of a well- characterized energy-transducing bacteriorhodopsin-liposomal system utilizing BR-trimers rather than BR monomers. The write-up of the description of our computer-based system for monitoring the efficiency of energy-transduction by BR liposomes was completed, submitted, and accepted for publication (J. Biochem. Biophys. Meths.).

该项目去年被“暂时搁置”，以便全面实施 实验室的工作可以集中在动力学分析上 细胞色素 aa3 (cox) 和细菌视紫红质 (BR) (HL00401-29 LCB)。这 将我们所有资源投入另一个项目的决定是基于 事实上，考克斯和 BR 的调查为这两项追求奠定了基础 我们认为有必要立即追求的进展。在 新的一年，我们将继续致力于发展一个良好的 特征性能量转导细菌视紫红质脂质体系统 使用 BR 三聚体而不是 BR 单体。所写的 我们用于监控效率的计算机系统的描述 BR脂质体能量转导的研究已完成、提交并 接受发表（J. Biochem. Biophys. Meths.）。