PREVALENCE OF HIV AND PREGNANCY IN CALIFORNIA ARRESTEES

加州被捕者的艾滋病毒感染率和怀孕情况

• 批准号: 2377418
• 负责人: MDouglas Douglas ANGLIN
• 金额: $ 5.75万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 1998-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2377418
• 关键词: HIV infections; behavioral /social science research tag; clinical research; diagnosis design /evaluation; diagnostic tests; drug detection; enzyme linked immunosorbent assay; epidemiology; female; high risk behavior /lifestyle; human pregnant subject; human subject; interview; legal /correctional; pregnancy; pregnancy infection; pregnancy tests; urinalysis

The possibility of assessing HIV prevalence and pregnancy status by conducting HIV and pregnancy tests on anonymously collected urine specimens will be explored. A low-cost feasibility study is proposed using arrestees participating in an on-going needs assessment survey as part of the California Drug Use Forecasting (CAL-DUF) Program. While drug abusers, who constitute the majority of arrestees, are among the highest risk groups for HIV infection, the rates of HIV positivity are not well documented among key subgroups of drug abusers, especially non-injection users. Furthermore, female arrestees, most of whom are in their prime child-bearing years, are likely to engage in high-risk sex without effective use of contraception, and to have high pregnancy rates. This application addresses the following goals: 1) to assess the feasibility of applying urine-based techniques for determining HIV-1 antibody and pregnancy status within an ongoing field study of arrestees; 2) to document the prevalence of HIV and pregnancy among arrestees and to compare these rates to other at-risk populations; and 3) to assess relationships among demographic factors, risk behaviors, and HIV and pregnancy status. Seven counties from the 15-county CAL-DUF study, representing both southern and northern California and making up approximately 63% of the state's population, will participate. These counties represent urban areas where a constellation of related public health problems exist. Approximately 200 men and 100 women arrestees from each county will be interviewed with a final aggregate sample of approximately 2100 arrestees, comprised of 75% men and 25% women, with an ethnic distribution of 45% white, 35% Mexican-American, and 20% African- American. We will conduct HIV testing using a microplate ELISA (Calypte Biomedical) and a modified Western Blot as a confirmatory test. Urine pregnancy testing will be done with the Early Pregnancy Test (EPT) (Warner- Lambert Co.).

通过评估HIV患病率和怀孕状况的可能性 对匿名收集的尿液标本进行艾滋病毒和妊娠试验 将被探索。使用被捕者提出了一项低成本可行性研究 作为持续的需求评估调查作为一部分 加利福尼亚药物使用预测（CAL-DUF）计划。而毒品滥用者，谁 构成大多数被捕者，是最高风险群体之一 艾滋病毒感染，艾滋病毒阳性率没有很好地证明 吸毒者的关键亚组，尤其是非注射使用者。此外， 女性被捕者，其中大多数处于主要育儿岁月，是 可能无效地从事高风险性行为， 并具有较高的妊娠率。此应用程序解决以下 目标：1）评估应用基于尿液的技术的可行性 确定正在进行的领域内HIV-1抗体和妊娠状态 被捕者的研究； 2）记录艾滋病毒和怀孕的患病率 在被捕者中，将这些速度与其他高危人群进行比较； 3）评估人口因素，风险行为之间的关系， 以及艾滋病毒和怀孕状况。 15县Cal-Duf的七个县 研究，代表南部和北加州并弥补 该州大约有63％的人口将参加。这些 县代表着相关公众星座的城市地区 存在健康问题。大约200名男子和100名女性被捕者 每个县将接受采访的最终样本 约有2100名被捕者，由75％的男性和25％的女性组成 族裔分布为45％白人，墨西哥裔美国人和20％的非洲人分布 美国人。我们将使用微板ELISA进行HIV测试（Calypte 生物医学）和改良的蛋白质印迹作为确认性测试。尿 怀孕测试将通过早期妊娠试验（EPT）进行（Warner- 兰伯特公司）。