LAAM MAINTENANCE--HIV RISK REDUCTION POTENTIAL

LAAM 维护——降低艾滋病毒风险的潜力

基本信息

批准号：
2898046
负责人：
MDouglas Douglas ANGLIN
金额：
$ 26.78万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-30 至 2001-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2898046
关键词：
clinical research drug abuse chemotherapy drug addiction heroin high risk behavior /lifestyle human subject human therapy evaluation methadone methadylacetate

项目摘要

DESCRIPTION: (Applicant's Abstract) The UCLA Drug Abuse Research Center, in collaboration with the Matrix Institute on Addictions, is resubmitting a proposal for a 42-month project to examine the effectiveness of levo-alpha-aceyl methadol (LAAM) as a treatment intervention for high-risk heroin addicts with AIDS prevention aspects equal or superior to methadone maintenance (MM). The proposed study uses a repeated measures design which involves randomly assigning 300 addicts (initially selected subjects and subjects to replace attrition) to two groups, MM or LAAM maintenance, for a period of twelve months of subsidized treatment. All subjects will be assessed at the beginning of treatment, at six months, twelve months, and eighteen months after treatment entry. The specific aims of the study are: (1) to test the overall effectiveness of LAAM in reducing high-risk behaviors associated with HIV infection; (2) to determine which medication and patient characteristics contribute to improved long-term retention and clinic attendance in LAAM treatment compared with MM treatment; and (3) to compare the effectiveness of LAAM and MM in reducing HIV risk behaviors associated with heroin addiction, particularly as related to subject demographic and psychosocial characteristics. The proposed project will use repeated measures ANOVA, survival analyses, and multiple or logistic regression analyses to assess these aims.

描述：（申请人的摘要）加州大学洛杉矶分校药物滥用研究中心与矩阵合作成瘾研究所，正在重新提交一个为期42个月的项目检验Levo-Alpha-aceyl hisadol（Laam）的有效性预防艾滋病的高风险海洛因吸毒者的治疗干预措施方面相等或优于美沙酮维护（MM）。拟议的研究使用重复测量设计，涉及随机分配300 瘾君子（最初选择的主题和受试者替换流失）两个组，MM或LAAM维护，长达十二个月补贴治疗。所有受试者将在开始时进行评估治疗后六个月，十二个月和十八个月的治疗入口。该研究的具体目的是：（1）测试总体 LAAM在降低与HIV相关的高风险行为方面的有效性感染; （2）确定哪种药物和患者特征有助于改善LAAM的长期保留和诊所出勤与MM治疗相比治疗；（3）比较有效性 LAAM和MM的降低与海洛因相关的艾滋病毒风险行为成瘾，特别是与主题人群和社会心理有关特征。拟议的项目将使用重复测量方差分析，生存分析以及多个或逻辑回归分析以评估这些目标。