OBJECTIVE TEST FOR EARLY PARKINSONS SYNDROME

早期帕金森综合症的客观测试

• 批准号: 2766808
• 负责人: Erwin B. Montgomery
• 金额: $ 37.62万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-05 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2766808
• 关键词: Alzheimer's disease; Parkinson's disease; brain disorder diagnosis; clinical research; depression; diagnosis design /evaluation; early diagnosis; human subject; neuropsychological tests; olfactions; psychomotor function; tremor

DESCRIPTION: (Applicant's Abstract) The goal of the proposed project is to develop a battery of tests (PD Battery) that could provide an inexpensive and objective aid for, first, the early diagnosis of Parkinson's syndrome (PS) and second, to aid in its differential diagnosis, such as idiopathic Parkinson's disease (iPD); Parkinson-Plus syndromes (P-Plus) such as striato-nigral degeneration; and essential tremor (ET) as distinguished from tremor predominant parkinsonism and others. The PD Battery has been developed that, in preliminary studies, clearly distinguishes between normal control (NC) subjects and patients with early mild presumptive iPD (95 percent sensitivity, 94 percent specificity and the area under the receiver-operator curve [ROC] of 0.98). The battery incorporates tests of motor function, olfaction, and affective state (i.e., depression). When additional NC subjects and iPD patients were studied in a prospective manner, the test battery correctly identified 44 of 48 NC subjects and 10 of the 11 iPD patients. In addition, 7 of 9 patients with ET had test results in the normal range suggesting that the battery can aid in the differentiation of tremor predominant iPD and ET. The next step is to validate the PD Battery by prospectively testing patients in whom PS is suspected but the diagnosis is uncertain (the Uncertain PS group). These patients will undergo the PD Battery, Unified Parkinson Disease Rating Scale (UPDRS) upon entrance into the study. Two years later, a MRI scan and the UPDRS and motor testing before and after levodopa administration will be done. These tests should identify which of these patients become probably normal, probably iPD or Probable P-Plus. Results of these evaluations will be correlated with their results from the PD Battery at time of entrance into the study. To further validate the battery, more NC subjects and patients with: 1) newly diagnosed and mildly affected PS; 2) P-Plus syndromes; 3) ET; 4) mild Alzheimer's disease (AD) and 5) AD with parkinsonian features (AD/PD) will be tested. If successful, the PD Battery could help assure appropriate patients receive appropriate care, thus, minimizing health costs and disability. In the future, the PD Battery could allow early or pre-clinical detection of persons at risk. this battery for early detection, coupled with future neuro-protective therapies, could further reduce health costs and disability. In addition , the test battery could be used in the future to aid research into the possible genetic and/or environmental causes of iPD.

描述：（申请人的摘要）拟议项目的目标是 开发一系列测试（PD电池），可以提供便宜的测试 首先是对帕金森综合症的早期诊断的客观辅助 （PS），其次，为了帮助进行鉴别诊断，例如特发性 帕金森氏病（IPD）；帕金森 - 加人综合症（P-Plus），例如 纹状体二元变性；和基本震颤（ET）与 震颤主要的帕金森主义等。 PD电池已经 在初步研究中，开发了这一点，明确区分了正常 对照（NC）受试者和早期自然推定性IPD患者（95 敏感性，94％的特异性和面积的面积 接收器 - 操作员曲线[ROC]为0.98）。 电池结合了测试 运动功能，嗅觉和情感状态（即抑郁症）。 什么时候 在预期中研究了其他NC受试者和IPD患者 方式，测试电池正确识别了48名NC受试者中的44个和10个 11名IPD患者。 此外，9名ET患者中有7名具有测试结果 在正常范围内，表明电池可以帮助 震颤主要IPD和ET的分化。 下一步是通过前瞻性测试来验证PD电池 怀疑PS但诊断不确定的患者（该患者 不确定的PS组）。 这些患者将接受PD电池，统一 帕金森氏病评级量表（UPDRS）进入研究后。 二 多年后，MRI扫描和UPDRS和运动测试之前和之后 将完成左旋多巴管理。 这些测试应确定哪个 这些患者可能变得正常，可能是IPD或可能的P-Plus。 这些评估的结果将与它们的结果相关 进入研究时的PD电池。 进一步验证 电池，更多的NC受试者和患者：1）新诊断并温和 受影响的PS； 2）P-Plus综合征； 3）ET; 4）轻度阿尔茨海默氏病（AD） 5）将测试带有帕金森氏症功能（AD/PD）的广告。 如果成功，PD电池可以帮助确保适当的患者接受 因此，适当的护理，从而最大程度地减少了健康成本和残疾。 在 未来，PD电池可以允许早期或临床前检测 有风险的人。 该电池以备早期检测，再加上未来 神经保护疗法可以进一步降低健康成本和 残疾。 此外，将来可以使用测试电池 帮助研究IPD的遗传和/或环境原因。