PHYSIOLOGY AND PATHOPHYSIOLOGY OF BASAL GANGLIA IN PARKINSON?S DISEASE

帕金森病基底节的生理学和病理生理学

• 批准号: 7716418
• 负责人: Erwin B. Montgomery
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716418
• 关键词: Animals; Basal Ganglia; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Data; Deep Brain Stimulation; Functional disorder; Funding; Grant; Institution; Laboratories; Macaca mulatta; Methodology; Methods; Microelectrodes; Modeling; Motor; Motor Cortex; Movement Disorders; Parkinson Disease; Parkinsonian Disorders; Physiology; Research; Research Personnel; Resources; Services; Source; System; Thalamic structure; United States National Institutes of Health; new technology; sensory cortex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To use rhesus monkey (Macaca mulatta) models of Parkinsonism and deep brain stimulation (DBS) as a way to probe how the basal ganglia and the motor and sensory cortex act as a functioning unit. To develop and advance the methods of Epidural Motor Cortex Stimulation for movement disorders. Develop and advance computational modeling of the basal ganglia-thalamic-cortical system and the effects of DBS. The laboratory is fully functional. We have developed new technologies and methodologies for data accusation and analysis. Microelectrode recordings in the basal ganglia-thalamic-cortical system in a behaving rhesus monkey. This research used WNPRC Animal Services and WNPRC Operational Services (Shop). Support is from Medtronic Neuromodulation, Inc.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 使用帕金森氏症和深脑刺激（DBS）模型的恒河猴（Macaca Mulatta）模型来探测基底神经节，运动和感觉皮层如何起作用。 开发和推进硬膜外运动皮层刺激运动障碍的方法。 开发和推进基底神经节 - 丘脑形成系统和DBS效应的计算建模。 实验室功能齐全。 我们开发了用于数据指控和分析的新技术和方法。 在表现恒河猴中的基底神经节 - 丘脑皮层系统中的微电极记录。这项研究使用了WNPRC动物服务和WNPRC操作服务（SHOP）。 支持来自Medtronic Neuromodulation，Inc.。