DIETARY CALCIUM AND BONE LOSS IN PREMENOPAUSAL WOMEN

绝经前女性的膳食钙和骨质流失

• 批准号: 2414876
• 负责人: DANIEL T. BARAN
• 金额: $ 26.18万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2414876
• 关键词: Hispanic Americans; bone density; calcium; caucasian American; cholecalciferol; clinical trials; collagen; dietary calcium; dietary supplements; female; human subject; human therapy evaluation; metabolism disorder chemotherapy; nutrition related tag; osteocalcin; osteoclasts; osteoporosis; skeletal disorder chemotherapy; women's health; young adult human (21-34)

DESCRIPTION: (Adapted from the Investigator's Abstract) Osteoporosis affects 15-20 million women in the United States. Prevention of this disease would be more beneficial and economical than treating the disease once bone loss and fractures have occurred. Dietary calcium has been implicated in the regulation of bone turnover. Inadequate calcium intake has been postulated to be important in the development of osteoporosis in women. Studies have reported that increased calcium intake in premenopausal women is associated with increased bone mass and results in greater bone mass as these women enter menopause. In a randomized, prospective 3-year study, diet modification with dairy products has been shown to retard vertebral bone loss in 30- to 42-year- old premenopausal women-compared to age-matched controls. This resulted in a statistically significant 2.9% difference in vertebral bone mass in the supplemented group after 2.5 and 3 years. Increased dietary calcium intake was reflected in increased urinary calcium excretion. Because the non-supplemented women lost bone at a rate of 2.9%/3 yr, prevention of bone loss by calcium supplementation during the premenopausal years could result in greater bone mass as these women enter menopause decreasing their risk of future fracture. It is the hypothesis of this proposal that calcium supplementation in women who have attained their peak bone mass will prevent the subsequent bone loss that occurs prior to menopause. This proposal will be a randomized, double-blind, placebo controlled intervention trial in 150 women to: (1) Determine the rates of vertebral, femoral (neck, trochanter, Ward's triangle), and forearm bone density changes in premenopausal Caucasian and Hispanic women, age 35-43; (2) Assess the effect of calcium supplementation (900 mg Calcium/d) on bone loss in these women; (3) Examine changes in markers of osteoblast (osteocalcin) and osteoclast (TRAP, type I collagen cross-linked N-telopeptides) activity in these women.

描述：（改编自研究者摘要）骨质疏松症 影响美国 15-2000 万女性。 预防这种情况 疾病比治疗更有益和更经济 一旦发生骨质流失和骨折，就会发生疾病。 膳食钙有 参与骨转换的调节。 钙质不足 摄入量被认为对发展很重要 女性骨质疏松症。 研究表明，增加钙 绝经前妇女的摄入量与骨量增加有关 当这些女性进入更年期时，会导致骨量增加。 在一个 随机、前瞻性 3 年研究，乳制品饮食调整 产品已被证明可以在 30 至 42 年内延缓椎骨流失 老年绝经前女性——与年龄匹配的对照组相比。 这导致了 椎骨质量差异具有统计显着性 2.9% 2.5年和3年后的补充组。 增加膳食钙 摄入量反映在尿钙排泄增加。 因为 未补充补充剂的女性骨质流失率为 2.9%/3 年，可预防 绝经前几年补钙导致的骨质流失 当这些女性进入更年期时，可能会导致骨量增加 降低未来骨折的风险。 该提案的假设是，钙补充剂 达到峰值骨量的女性将预防随后的骨量增加 绝经前发生的骨质流失。 该提案将是 150 名受试者参与的随机、双盲、安慰剂对照干预试验 女性： (1) 确定椎骨、股骨（颈、 转子、沃德三角）和前臂骨密度的变化 绝经前白人和西班牙裔女性，年龄 35-43 岁； (2) 评估 钙补充剂（900 毫克钙/天）对骨质流失的影响 这些妇女； （3）检查成骨细胞标志物（骨钙素）的变化 和破骨细胞（TRAP，I 型胶原交联 N-端肽） 这些女性的活动。