Anemia and Its Relationship with Sarcopenia, Physical Function, and Mortality

贫血及其与肌肉减少症、身体功能和死亡率的关系

基本信息

批准号：
7570020
负责人：
Zhao Chen
金额：
$ 17.93万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-15 至 2011-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7570020
关键词：
Address Adverse effects African American Age Aging American Anemia Anemia due to Chronic Disorder Archives Arizona Arthritis Asians Blood Blood specimen Body Composition Bone Density Calcium Cardiovascular Diseases Cardiovascular system Categories Cessation of life Chronic Clinical Clinical Trials Data Data Analyses Data Reporting Development Diabetes Mellitus Diagnosis Diet Modification Dietary Factors Dietary intake Disease Dual-Energy X-Ray Absorptiometry Elderly Elderly woman Enrollment Epidemiology Ethnic Origin Ethnic group Event Fracture Frequencies Functional disorder Funding Health Hemoglobin Hemoglobin concentration result Hispanics Hormones Hospitalization Impaired cognition Intervention Malignant Neoplasms Measurement Measures Minority Modeling Morbidity - disease rate Muscle National Health and Nutrition Examination Survey Native Americans Natural History Nature Not Hispanic or Latino Observational Study Older Population Osteoporosis Outcome Pacific Island Americans Participant Pathology Pattern Performance Pharmaceutical Preparations Physical Function Physical activity Pilot Projects Population Population Heterogeneity Prevalence Principal Investigator Prospective Studies Questionnaires Race Reporting Research Research Design Research Personnel Resources Risk Risk Factors Sample Size Sampling Sensitivity and Specificity Series Skeletal Muscle Subgroup Supplementation Surveys Time Urine Variant Vitamin D Woman Women&apos s Health age group base behavioral health bone loss cohort cost cytokine depression disability ethnic difference falls follow-up functional status health disparity lifestyle factors mortality muscle form muscle strength older women osteoporosis with pathological fracture outcome forecast premature prevent programs prospective racial and ethnic disparities sarcopenia

项目摘要

DESCRIPTION (provided by applicant): Anemia is a common health problem in US older populations; and it increases the risk for disability, decline in physical performance, low muscle strength, and premature death in the elderly. A recent study from NHANES III reported the prevalence of anemia being larger than 10% in the US population over age 65, and the prevalence of anemia varied by ethnicity, suggesting significant health disparities in minorities, especially in the African American population. In this study, a large (N >160,000) multiethnic (non-Hispanic white, Hispanic, African American, Native American, Asian/Pacific Islander) cohort from the nationwide Women's Health Initiative (WHI) study will be used to investigate the relationships of aging with anemia epidemiology, pathology and prognosis. Specifically, we will 1) evaluate the frequency of and risk factors for anemia overall and according to race-ethnicity and co-morbidity; 2) determine the association between anemia and risk of death over 10 years of follow-up in the WHI overall and by race-ethnicity; 3) determine associations between anemia and changes in physical function over 9 years of follow-up in the WHI cohort overall and by race- ethnicity; 4) examine associations of anemia with muscle loss (sarcopenia) among those with baseline and prospective measurements of body composition from dual-energy x-ray absorptiometry; and 5) study the association of anemia with bone loss and risk for osteoporotic fractures in older women. In addition, the frequency of anemia subtypes by morphologic categories and optimal cutoff points of hemoglobin concentrations for anemia in older women will be evaluated. This study will use archived observational and clinical trial data from 40 WHI clinical centers. Additional data entering for blood analysis from existing reports, and data merging (body composition measurements) will be conducted in the WHI DXA cohort from Arizona, Birmingham and Pittsburgh. Multivariate data analyses will be conducted for the specific aims. The WHI provides a unique and invaluable resource for answering the research questions proposed above, as the WHI is the only study in the nation that has prospective co-morbidities and body composition data as well as hemoglobin values in multiethnic groups of older women. This study has a great potential to provide new and critical evidence that is needed for preventing and managing anemia in older women from different health, age and ethnic backgrounds.

描述（由申请人提供）：贫血是我们较老的人群的常见健康问题；它增加了残疾的风险，身体表现降低，肌肉力量低以及老年人的过早死亡。 NHANES III的最新研究报告说，在65岁以上的美国人口中，贫血大于10％，贫血的患病率因种族而有所不同，这表明少数群体的健康差异很大，尤其是在非裔美国人人口中。在这项研究中，来自全国性的女性健康计划（WHI）研究将使用大型（N> 160,000）多民族（非西班牙裔白人，西班牙裔，非洲裔美国人，美国原住民，亚洲/太平洋岛民）研究来研究与衰老与贫血病学，病理学，病理学，病理学和预测的关系。具体而言，我们将1）评估总体贫血的频率和危险因素的频率和风险因素，并根据种族种族和合并症； 2）确定贫血与死亡风险之间的关联，在整个人类和种族中，在10年的随访中； 3）确定贫血与整体和种族的随访9年的随访时间之间的身体机能变化之间的关联； 4）检查贫血与肌肉丧失（肌肉减少症）的关联，并从基线和从双能X射线吸收仪中对身体成分进行了前瞻性测量； 5）研究老年女性贫血与骨质疏松骨折的风险的关联。此外，将评估贫血类别的贫血亚型的频率和老年女性贫血血红蛋白浓度的最佳临界点。这项研究将使用来自40个WHI临床中心的存档观察和临床试验数据。从现有报告中输入血液分析的其他数据，将在来自亚利桑那州，伯明翰和匹兹堡的WHI DXA队列中进行数据合并（身体组成测量）。将针对特定目的进行多元数据分析。 WHI提供了一种独特而宝贵的资源来回答上面提出的研究问题，因为WHI是全国唯一具有前瞻性合并症和人体组成数据以及在多民族老年妇女组中的血红蛋白价值的研究。这项研究具有提供新的和关键证据的巨大潜力，可以预防和管理来自不同健康，年龄和种族背景的老年妇女的贫血。