Anemia and Its Relationship with Sarcopenia, Physical Function, and Mortality

贫血及其与肌肉减少症、身体功能和死亡率的关系

• 批准号: 7570020
• 负责人: Zhao Chen
• 金额: $ 17.93万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7570020
• 关键词: Address; Adverse effects; African American; Age; Aging; American; Anemia; Anemia due to Chronic Disorder; Archives; Arizona; Arthritis; Asians; Blood; Blood specimen; Body Composition; Bone Density; Calcium; Cardiovascular Diseases; Cardiovascular system; Categories; Cessation of life; Chronic; Clinical; Clinical Trials; Data; Data Analyses; Data Reporting; Development; Diabetes Mellitus; Diagnosis; Diet Modification; Dietary Factors; Dietary intake; Disease; Dual-Energy X-Ray Absorptiometry; Elderly; Elderly woman; Enrollment; Epidemiology; Ethnic Origin; Ethnic group; Event; Fracture; Frequencies; Functional disorder; Funding; Health; Hemoglobin; Hemoglobin concentration result; Hispanics; Hormones; Hospitalization; Impaired cognition; Intervention; Malignant Neoplasms; Measurement; Measures; Minority; Modeling; Morbidity - disease rate; Muscle; National Health and Nutrition Examination Survey; Native Americans; Natural History; Nature; Not Hispanic or Latino; Observational Study; Older Population; Osteoporosis; Outcome; Pacific Island Americans; Participant; Pathology; Pattern; Performance; Pharmaceutical Preparations; Physical Function; Physical activity; Pilot Projects; Population; Population Heterogeneity; Prevalence; Principal Investigator; Prospective Studies; Questionnaires; Race; Reporting; Research; Research Design; Research Personnel; Resources; Risk; Risk Factors; Sample Size; Sampling; Sensitivity and Specificity; Series; Skeletal Muscle; Subgroup; Supplementation; Surveys; Time; Urine; Variant; Vitamin D; Woman; Women' s Health; age group; base; behavioral health; bone loss; cohort; cost; cytokine; depression; disability; ethnic difference; falls; follow-up; functional status; health disparity; lifestyle factors; mortality; muscle form; muscle strength; older women; osteoporosis with pathological fracture; outcome forecast; premature; prevent; programs; prospective; racial and ethnic disparities; sarcopenia

DESCRIPTION (provided by applicant): Anemia is a common health problem in US older populations; and it increases the risk for disability, decline in physical performance, low muscle strength, and premature death in the elderly. A recent study from NHANES III reported the prevalence of anemia being larger than 10% in the US population over age 65, and the prevalence of anemia varied by ethnicity, suggesting significant health disparities in minorities, especially in the African American population. In this study, a large (N >160,000) multiethnic (non-Hispanic white, Hispanic, African American, Native American, Asian/Pacific Islander) cohort from the nationwide Women's Health Initiative (WHI) study will be used to investigate the relationships of aging with anemia epidemiology, pathology and prognosis. Specifically, we will 1) evaluate the frequency of and risk factors for anemia overall and according to race-ethnicity and co-morbidity; 2) determine the association between anemia and risk of death over 10 years of follow-up in the WHI overall and by race-ethnicity; 3) determine associations between anemia and changes in physical function over 9 years of follow-up in the WHI cohort overall and by race- ethnicity; 4) examine associations of anemia with muscle loss (sarcopenia) among those with baseline and prospective measurements of body composition from dual-energy x-ray absorptiometry; and 5) study the association of anemia with bone loss and risk for osteoporotic fractures in older women. In addition, the frequency of anemia subtypes by morphologic categories and optimal cutoff points of hemoglobin concentrations for anemia in older women will be evaluated. This study will use archived observational and clinical trial data from 40 WHI clinical centers. Additional data entering for blood analysis from existing reports, and data merging (body composition measurements) will be conducted in the WHI DXA cohort from Arizona, Birmingham and Pittsburgh. Multivariate data analyses will be conducted for the specific aims. The WHI provides a unique and invaluable resource for answering the research questions proposed above, as the WHI is the only study in the nation that has prospective co-morbidities and body composition data as well as hemoglobin values in multiethnic groups of older women. This study has a great potential to provide new and critical evidence that is needed for preventing and managing anemia in older women from different health, age and ethnic backgrounds.

描述（由申请人提供）：贫血是美国老年人群中常见的健康问题；它还会增加老年人残疾、身体机能下降、肌肉力量低下和过早死亡的风险。 NHANES III 最近的一项研究报告称，美国 65 岁以上人口中贫血患病率超过 10%，并且贫血患病率因种族而异，表明少数族裔（尤其是非裔美国人）之间存在显着的健康差异。在这项研究中，来自全国妇女健康倡议 (WHI) 研究的一个大型 (N >160,000) 多种族（非西班牙裔白人、西班牙裔、非洲裔美国人、美洲原住民、亚洲/太平洋岛民）队列将用于调查衰老与贫血的流行病学、病理学和预后有关。具体来说，我们将 1) 根据种族和共病总体评估贫血的频率和危险因素； 2) 根据 WHI 整体和种族，确定贫血与死亡风险之间的关联超过 10 年； 3) 在整个 WHI 队列中按种族进行 9 年的随访，确定贫血与身体机能变化之间的关联； 4) 通过双能 X 射线吸收测定法对身体成分进行基线和前瞻性测量，检查贫血与肌肉损失（少肌症）之间的关系； 5) 研究老年女性贫血与骨质流失和骨质疏松性骨折风险的关系。此外，还将评估老年女性贫血按形态类别划分的贫血亚型频率和贫血血红蛋白浓度的最佳临界点。本研究将使用 40 个 WHI 临床中心的存档观察和临床试验数据。来自亚利桑那州、伯明翰和匹兹堡的 WHI DXA 队列将根据现有报告输入额外数据进行血液分析，并进行数据合并（身体成分测量）。针对具体目标，将进行多变量数据分析。 WHI 为回答上述研究问题提供了独特且宝贵的资源，因为 WHI 是全国唯一一项拥有多种族老年女性的预期共病、身体成分数据以及血红蛋白值的研究。这项研究具有巨大的潜力，可以为不同健康、年龄和种族背景的老年女性预防和管理贫血提供所需的新的关键证据。