Nutrition, Stress and Bone in Older Puerto Ricans

波多黎各老年人的营养、压力和骨骼

• 批准号: 7209940
• 负责人: Katherine L Tucker
• 金额: $ 63.48万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7209940
• 关键词: Address; Adult; Affect; Age; Agreement; Alcohol consumption; American; Amino Acids; Apolipoprotein E; Biological; Body mass index; Bone Density; Bone Development; Boston; C-reactive protein; Caffeine; Calcium; Candidate Disease Gene; Censuses; Chronic; Chronic stress; Collagen; Collagen Type I; Condition; Daily; Data; Detection; Diabetes Mellitus; Diagnosis; Diet; Dietary Factors; Dietary Fiber; Discrimination; Disease; Elderly; Emotional Stress; Endocrine; Environmental Risk Factor; Estrogen Receptor alpha; Estrogens; Ethnic group; Face; Family; Folate; Food; Foundations; Fracture; Frequencies; Gene Proteins; Genes; Genetic; Genotype; Goals; Grant; Health; Health Care Costs; Health Status; Heel; High Prevalence; Hip region structure; Hispanics; Homocysteine; Homocystine; Hormonal; Hormones; Hydrocortisone; Immigrant; Immune; Inflammation; Inflammatory; Institute of Medicine (U.S.); Insulin-Like Growth Factor I; Intake; Interleukin-1; Interleukin-6; Investigation; Knowledge; Life; Linguistics; Link; Longevity; Massachusetts; Measurement; Measures; Mediating; Menopause; Mental Depression; Methylenetetrahydrofolate reductase (NADPH); Mexican Americans; Micronutrients; Minority; Minority Groups; Mission; N-terminal; National Health Interview Survey; National Health and Nutrition Examination Survey; Neck; Neighborhoods; Not Hispanic or Latino; Nutrient; Nutritional; Nutritional status; Osteitis; Osteocalcin; Osteoporosis; Participant; Pattern; Persons; Phenotype; Physical activity; Physiological Adaptation; Plasma; Play; Population; Population Study; Prevalence; Prevention; Principal Investigator; Proteins; Psychosocial Stress; Public Health; Puerto Rican; Puerto Rico; Relative (related person); Reporting; Research Personnel; Risk; Risk Factors; Role; Sampling; Serum; Single Nucleotide Polymorphism; Smoking; Socioeconomic Status; Sparrows; Strategic Planning; Stress; Stressful Event; Subgroup; Surveys; Testing; Thinking; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; United States; United States Dept. of Health and Human Services; United States National Institutes of Health; Variant; Vegetable Proteins; Vertebral column; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B6; Vitamin D; Vitamin D3 Receptor; Vitamins; Walkers; Weight; Woman; Work; aged; allostasis; allostatic load; base; bone; bone health; bone metabolism; bone stress; bone turnover; cohort; comparison group; crosslink; disability; ethnic minority population; expectation; experience; fruits and vegetables; functional disability; gene environment interaction; gene interaction; health disparity; human TNF protein; improved; member; men; metabolic abnormality assessment; nutrition; older women; programs; relating to nervous system; response; sex; size; socioeconomics; stressor; tumor; urinary

DESCRIPTION (provided by applicant): Puerto Rican older adults living in the U.S. mainland have been identified as a group highly at-risk of excess chronic conditions. While it is clear that Puerto Ricans suffer from several chronic health conditions, much less is known about how osteoporosis, a major public health threat in the U.S., affects this population. We propose to extend our work in the currently ongoing cohort of 1,200 Puerto Rican adults, aged 50-75 y at baseline, who are participating in the Boston Puerto Rican Center on Population Health and Health Disparities [NIA Grant No. 5P01AG023394-02]. Because considerable amounts of data are already being collected with this cohort, the addition of bone related measurements to this study will provide a highly efficient way to examine additional hypotheses on nutrition and bone mineral density. We aim to 1) assess the status of bone mineral density in a group of Boston Puerto Rican adults, aged 52-77 y; 2) examine associations between dietary factors and BMD of the hip, spine, and total body and markers of bone turnover; 3) examine associations between stress and inflammation and BMD of the hip, spine, heel, and total body and markers of bone turnover; and 4)examine how dietary factors modulate the association between candidate genes and measures of bone health including BMD of the hip, spine, and total body and markers of bone turnover. This proposed project addresses the mission defined in the new NIH roadmap, to improve the nation's health by uncovering new knowledge in the prevention, detection, diagnosis, and treatment of disease and disability, with the ultimate goal of reducing and eliminating health disparities among racial and ethnic minorities.

描述（由申请人提供）：居住在美国大陆的波多黎各老年人已被确定为过度慢性病的高风险群体。虽然很明显，波多黎各人患有多种慢性健康状况，但对骨质疏松症是美国主要的公共卫生威胁如何影响这一人群的知识。我们建议在目前正在进行的1,200名波多黎各成年人的队列中扩展我们的工作，该公司在基线时为50-75岁，他们参加了波士顿波士顿人口健康和健康差异中心[NIA Grant No. 5P01AG01AG023394-02]。由于已经使用该队列收集了大量数据，因此在这项研究中添加相关的骨骼测量结果将提供一种高效的方法来检查营养和骨矿物质密度的其他假设。我们的目的是1）评估一组52-77 y的波士顿波士顿成年人中骨矿物质密度的状态； 2）检查饮食因素与臀部，脊柱和总体和骨转换标记的BMD之间的关联； 3）检查髋关节，脊柱，脚跟以及骨转换的全身和标记的压力与炎症与BMD之间的关联； 4）检查饮食因素如何调节候选基因与骨骼健康的措施之间的关联，包括髋关节，脊柱的BMD，总体和骨转换的标记。这项拟议的项目探讨了新的NIH路线图中定义的任务，以通过揭示预防，检测，诊断和治疗疾病和残疾的新知识来改善国家的健康，并最终的目标是减少和消除种族和少数民族的健康差异。