FALLS AND FRACTURES AMONG ELDERLY JAPANESE AMERICANS

日裔美国人中的跌倒和骨折

• 批准号: 2001414
• 负责人: PHILIP D ROSS
• 金额: $ 44.41万
• 依托单位: HAWAII OSTEOPOROSIS FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2001414
• 关键词: Japanese American; accidental falls; bone density; bone fracture; clinical research; disease /disorder proneness /risk; epidemiology; gender difference; hip fractures; human old age (65+); human subject; longitudinal human study; male; osteoporosis; radiography

The incidence of fractures due to osteoporosis and falls are highest among the elderly, and represent major health problems. Falls are an important risk factor for some types of fractures, and a principal cause of injuries, death, and disability among the elderly. The injuries and fear of falling that often develop after a fall can increase the level of frailty and dependence of the elderly. We have already shown that the incidence of nonspine fractures among Japanese men and women and only half that of Caucasians, even though bone density is similar after adjusting for body size. The incidence of falls is also half that of Caucasians. Preventing falls, fractures, and their consequences will require understanding the underlying causes, which may vary by gender and ethnicity. The Hawaii Osteoporosis Study (HOS) began in 1981 with a population-based sample of 1379 men (ages 60 to 81) and 1098 of their wives; all are of Japanese ancestry. Measurements of bone mineral density (BMD) and radiographs for identifying vertebral fractures were obtained in 1981, and again at subsequent examinations through 1995 for both men and women. Risk factor for falls were measured for the women and a subset of men in 1992 and again in 1995. We propose here to extend the existing longitudinal study of osteoporosis and falls among the HOS men to older ages, and expand it to include risk factors which were not measured previously. BMD and risk factors for factors for fractures and falls will be measured at the beginning and end of the study. Identical, standardized examinations of the wives (funded separately) will overlap with the examinations of men, resulting in reduced costs overall. The proposed examinations will provide prospective data regarding changes in BMD over a 21 year period (1981-2002), and risk factors for falls over 10 years (1992-2002). The new exams will also allow us to extend our study of the natural history of osteoporosis and falls to older ages, where more than half of all hop fractures occur, and provide greater statistical power for analyses. The proposed study will address many of the priority areas mentioned in the Program Announcement. It will investigate the incidence and prevalence of fractures and falls, distributions of risk factors, and changes in risk factors over time among elderly men, for whom little data are currently available. It will also evaluate the extent to which measured risk factors explain the observed difference in rates of fractures and falls between men and women, which may lead to better interventions.

骨质疏松和跌倒引起的骨折的发生率最高 在老年人中，代表了主要的健康问题。 瀑布是一个 某些类型的裂缝的重要危险因素和主要原因 老年人的伤害，死亡和残疾。 受伤和 害怕跌倒后经常出现的跌倒会增加 老年人的脆弱和依赖。 我们已经证明了 日本男性和女性中非洲骨折的发病率， 即使骨密度相似，也只有一半 调整体型。瀑布的发病率也是 高加索人。 防止跌倒，断裂及其后果 需要了解基本原因，这可能因性别而异 和种族。 夏威夷骨质疏松研究（HOS）始于1981年 由1379名男子（60至81岁）和1098的基于人口的样本 他们的妻子；所有都是日本血统。 骨头的测量 用于识别椎骨的矿物密度（BMD）和X光片 骨折是在1981年获得的，并在随后的检查中再次获得 直到1995年，男人和女人。跌倒的危险因素是 在1992年为妇女和男性的一部分测量 1995年。我们在这里提议扩展现有的纵向研究 骨质疏松症和落在Hos男性中的年龄较大，并扩大 它包括以前未测量的风险因素。 BMD 裂缝和跌倒因素的风险因素将在 研究的开始和结尾。 相同，标准化 妻子的考试（分别资助）将与 男性考试，总体上降低了成本。提议 考试将提供有关BMD变化的预期数据 在21年（1981- 2002年）中，跌倒的风险因素超过10 年（1992-2002）。 新考试还可以使我们扩展 研究骨质疏松症的自然史，跌至年龄较大， 在所有啤酒花裂缝中发生的一半以上，并提供更大的地方 分析的统计能力。 拟议的研究将解决许多 计划公告中提到的优先领域。 会 调查裂缝和跌倒的发病率和患病率， 随着时间的推移，风险因素的分布和风险因素的变化 在老年人中，目前几乎没有数据。 会 还评估测量的风险因素解释多大程度 观察到的男性骨折和跌倒率差异 妇女，这可能会导致更好的干预措施。

项目成果

Relation of height and weight to the regional variations in bone mass among Japanese-American men and women.

日裔美国男性和女性身高和体重与骨量区域差异的关系。

• DOI: 10.1007/bf01774012
• 发表时间: 1995
• 期刊: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
• 作者: Davis,JW;Ross,PD;Wasnich,RD
• 通讯作者: Wasnich,RD

Short-term and long-term fracture prediction by bone mass measurements: a prospective study.

通过骨量测量预测短期和长期骨折：一项前瞻性研究。

• DOI: 10.1359/jbmr.1998.13.1.107
• 发表时间: 1998
• 期刊: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
• 作者: Huang,C;Ross,PD;Wasnich,RD
• 通讯作者: Wasnich,RD

A longitudinal study of estrogen and calcium supplement use among Japanese women living in Hawaii.

居住在夏威夷的日本女性雌激素和钙补充剂使用情况的纵向研究。

• DOI: 10.1006/pmed.1995.1029
• 发表时间: 1995
• 期刊: Preventive medicine.
• 作者: Davis,JW;Ross,PD;Wasnich,RD
• 通讯作者: Wasnich,RD

Blinded reading of radiographs increases the frequency of errors in vertebral fracture detection.

盲读射线照片会增加椎体骨折检测中的错误频率。

• DOI: 10.1002/jbmr.5650111124
• 发表时间: 1996
• 期刊: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
• 作者: Ross,PD;Huang,C;Karpf,D;Lydick,E;Coel,M;Hirsch,L;Wasnich,RD
• 通讯作者: Wasnich,RD

Incidence rates of falls among Japanese men and women living in Hawaii.

居住在夏威夷的日本男性和女性的跌倒发生率。

• DOI: 10.1016/s0895-4356(96)00430-1
• 发表时间: 1997
• 期刊: Journal of clinical epidemiology
• 影响因子: 7.2
• 作者: Davis,JW;Ross,PD;Nevitt,MC;Wasnich,RD
• 通讯作者: Wasnich,RD