Osteporotic Fractures in Men (MrOS)- Admin Center

男性骨质疏松性骨折 (MrOS)- 管理中心

• 批准号: 7193200
• 负责人: ERIC S. ORWOLL
• 金额: $ 47.02万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7193200
• 关键词: accidental falls; aging; biomarker; biomechanics; body physical activity; bone density; bone fracture; clinical research; cooperative study; disease /disorder proneness /risk; estradiol; femur; functional ability; hip fractures; hormone metabolism; human old age (65+); human subject; lifestyle; longitudinal human study; male; osteoporosis; parathyroid hormones; quality of life; questionnaires; testosterone; vitamin D deficiency

DESCRIPTION (provided by applicant): The Osteoporotic Fractures in Men (MrOS) study was formed primarily to quantify the determinants of fracture in men. Importantly, the MrOS cohort also provides a seminal opportunity to study men as they progress through a critical period of life in which problems of aging remain poorly understood. In 2000-2002, 5995 community-dwelling men ages 65 years and older (mean age: 72 years at baseline) were enrolled from 6 diverse US communities. The study is directed by the Administrative Center in Portland OR, and study wide coordination, communication and data management occurs at the Coordinating Center in San Francisco CA. After 5 years of follow-up, participant retention is excellent (99% of those alive remain active). We propose a new clinic visit and continued follow-up of the cohort to expand our understanding of risk factors for falls, fractures (particularly hip fracture) and other consequences of aging. At baseline, both areal (from DXA) and volumetric (from QCT) skeletal assessments were obtained. We propose to repeat the same assessments in the planned visit to identify the densitometric and biomechanical risk factors for hip fracture, as well as to characterize bone geometry changes that underlie skeletal fragility. Further, we will use the QCT scans to quantify femoral strength by finite element modeling (FEM), and assess the usefulness of FEM for fracture prediction. Additional follow-up of the cohort and repeat measures of muscle strength (grip strength, leg power), physical performance (gait speed, chair stands, and narrow walk), and self-reported physical activity will enable us to establish the extent and nature of change in activity and physical performance, identify biological predictors of these changes, and clarify the possibly joint effects of physical activity and physical performance on fracture risk. To objectively quantify physical activity we propose to obtain accelerometry measures at the new clinic visit. Using serum archived at baseline, we will test the hypothesis that renal function, vitamin D, parathyroid hormone have important effects on skeletal health, physical function and fracture risk, and will determine if lower sex steroid levels increase men's risk of skeletal deterioration and fracture, decline in physical function, and deterioration in quality of life. Study leadership will continue at the Administrative Center in Portland and management of study operations will occur at the Coordinating Center in San Francisco. Combined with the considerable data and biologic specimens already collected, additional measures and extended follow-up in the MrOS cohort allows us to expand the understanding of hip fractures, the most devastating type of fracture in men, as well as address other health issues of compelling public health and clinical importance to older US men.

描述（由申请人提供）：形成了男性（MROS）研究中的骨质疏松性骨折，主要是为了量化男性骨折的决定因素。重要的是，MROS队列还提供了一个精确的机会来研究男性，因为他们在一个关键的生活中进步，在这种关键时期，衰老问题仍然了解得很糟糕。在2000 - 2002年，有5995名65岁及65岁以上的社区居民（平均年龄：72岁时的基线年龄）从美国6种不同的社区中招募。该研究由波特兰的行政中心指导，或者研究广泛的协调，通信和数据管理发生在旧金山CA的协调中心。经过5年的随访后，参与者保留率非常好（活着的人中有99％保持活跃）。我们建议对队列进行新的诊所访问，并继续进行随访，以扩大我们对跌倒，骨折（尤其是髋部骨折）和其他衰老后果的危险因素的理解。在基线时，获得了面积（来自DXA）和体积（来自QCT）的骨骼评估。我们建议在计划的访问中重复相同的评估，以确定髋部骨折的密度和生物力学风险因素，并表征骨骼脆弱性构成的骨几何变化。此外，我们将使用QCT扫描通过有限元建模（FEM）来量化股骨强度，并评估FEM对断裂预测的有用性。对队列的进一步随访和肌肉力量的重复度量（抓地力，腿部力量），身体表现（步态速度，椅子架和步行狭窄）以及自我报告的体育锻炼将使我们能够确定活动和身体性能变化的程度和性质，并确定这些变化的生物学预测因子，并确定这些变化的生物学预测因素，并阐明运动和身体性能对身体性能的可能影响。为了客观地量化身体活动，我们建议在新的诊所就诊时获得加速度计量指标。使用基线时存档的血清，我们将检验以下假设：肾功能，维生素D，甲状旁腺激素对骨骼健康，身体功能和断裂风险具有重要影响，并确定较低的性类固醇水平是否会增加男性骨骼恶化和骨骼骨折的风险，物理功能的下降，以及生命质量的质量。研究领导将继续在波特兰的行政中心继续进行，研究运营的管理将在旧金山的协调中心发生。结合已经收集的大量数据和生物学标本，MROS队列中的其他措施和扩展的随访，使我们能够扩展对髋部骨折的理解，男性中最具毁灭性的骨折类型，以及解决强迫公共卫生和临床重要性的其他健康问题。