FUNCTIONAL ORGANIZATION OF AUDITORY CORTEX

听觉皮层的功能组织

• 批准号: 2445448
• 负责人: WILLIAM C LOFTUS
• 金额: $ 1.45万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2445448
• 关键词: afferent nerve; auditory cortex; auditory discrimination; auditory stimulus; behavioral /social science research tag; brain mapping; cats; electrostimulus; gamma aminobutyrate; microelectrodes; muscimol; neural information processing; thalamus; tungsten

The long-term goal of the proposed research is to understand how the functional divisions of auditory cortex relate to the analysis of complex sounds. Investigation will focus on the processing of intensity and temporal information in the auditory central nervous system (CNS) of the cat. The anatomical connections and architectonic parcellation of this system is well studied but much less is known about its functional organization. Two cortical regions: primary auditory cortex (AI) and posterior auditory field (PAF) will be the subject of physiological studies with these specific aims: l) to investigate the relationship between the response properties of geniculocortical afferents and the cortical cells to which the afferents provide input, and 2) to investigate the subconical organization of those afferents. Electrophysiological recordings will be acquired in either hemisphere of anesthetized cats under contralateral ear stimulation. For aim 1, single cortical neurons will be characterized in terms of their intensity tuning or temporal integration properties. The response of the cortical cells will then be pharmacologically silenced, which will enable recording from thalamic afferents in the same electrode penetration. For aim 2, recordings will be made from the cell bodies of afferents while simultaneously recording from cortical cells to which they provide input. The afferent recordings will be compared to the cortical recordings and interpreted in terms of the cortical transformations of afferent inputs. The subcortical organization of the inputs to PAF and AI will be compared and interpreted in terms of parallel and hierarchical organization of function. The results of these investigations will be relevant to understanding the basis of auditory perception and disturbances in auditory perception due to acquired lesions, developmental learning impairments, and schizophrenia.

拟议研究的长期目标是了解 听觉皮层的功能划分与复杂分析有关 听起来。调查将集中于强度的处理 听觉中枢神经系统（CNS）中的时间信息 猫。解剖学连接和建筑构造 对系统的研究进行了充分研究，但对其功能知之甚少 组织。两个皮质区域：主要听觉皮层（AI）和 后听觉领域（PAF）将是生理的主题 以这些特定目的的研究：l）研究关系 在基因皮质传入的响应特性与 传入提供输入的皮质细胞，以及2） 这些传入的次距组织。电生理学 记录将在麻醉猫的任何一个半球中获取 在对侧耳朵刺激下。对于AIM 1，单皮质神经元 将根据其强度调整或时间来表征 集成属性。然后，皮质细胞的响应将是 药理学沉默，这将使丘脑记录 相同电极穿透的传入。对于AIM 2，录音将是 由传入的细胞体制成，同时录制 它们提供输入的皮质细胞。传入录音将 与皮质记录进行比较，并用 传入输入的皮质转化。皮层组织 PAF和AI的输入将以用来比较和解释 功能的平行和分层组织。这些结果 调查将与理解听觉的基础有关 因获得的感知和听觉感知的干扰 病变，发展学习障碍和精神分裂症。