LORAZEPAM INDUCED COGNITIVE IMPAIRMENT ON TASK PERFORMANCE IN ADULTS

劳拉西泮导致成人任务表现认知障碍

• 批准号: 5216216
• 负责人: Neil Alexander
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5216216
• 关键词: accidents; age difference; balance; clinical research; cognition; drug adverse effect; human old age (65+); human subject; lorazepam; young adult human (21-34)

In order to determine the relationship between psychotropic drug use and falls in older adults, we gave 2 mg of lorazepam to healthy young (n=9, mean age 24) and older (n=8, mean age 71) females in a double blind, placebo-controlled experiment. The old had disproportionately greater drug-induced decrements in stepping accuracy and cognitive impairment, suggesting a possible mechanism for drug-induced falls.

为了确定精神药物使用与 跌倒在老年人中，我们给健康的年轻人给了2毫克的Lorazepam（n = 9， 平均年龄24）及以上（n = 8，平均年龄71）女性在双盲中， 安慰剂对照实验。 旧的不成比例更大 药物引起的阶梯准确性和认知障碍的降低， 提出了药物引起的跌倒的可能机制。