FASEB CONFERENCE ON UBIQUITIN AND PROTEIN DEGRADATION

FASEB 泛素和蛋白质降解会议

• 批准号: 2024156
• 负责人: ARTHUR L HAAS
• 金额: $ 0.2万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-28 至 1998-06-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2024156
• 关键词: meeting /conference /symposium; protein degradation; ubiquitin

DESCRIPTION: This application requests partial funding for a conference on Ubiquitin and Intracellular Protein Degradation to be held 28 June 1997 through 3 July 1997 at the conference Center of Vermont Academy, Saxtons River, VT. This Biennial conference, which was initiated in 1989, is sponsored by and receives partial funding from the Federation of the American Societies of Experimental Biology (FASEB). It is the only regularly scheduled international meeting devoted to this important area of research. The mechanisms and regulation of intracellular protein degradation are of fundamental importance in determining the overall protein content and steady state levels of particular intracellular proteins. The central pathway of protein turnover within eucaryotes is ubiquitin- and ATP-dependent and requires the 26S proteasome. Ubiquitin is a low molecular weight, highly conserved polypeptide that exerts it biological effect through its covalent conjugation to other proteins in an enzymatic pathway requiring ATP hydrolysis. The ligation of ubiquitin to proteins, or more correctly the formation of multiubiquitin chains, serves as a recognition signal for binding of the target protein to the 26S proteasome through specific interaction with subunit 5a of the 19S regulatory complex of the proteasome. This pathway is responsible for the degradation of constitutively and conditionally short-lived proteins including those of abnormal structure generated by environmental stress or mutation as well as various other key regulatory proteins including transcription factors, oncogenes, membrane receptors, and cyclins. The 1997 meeting will be organized into nine sessions comprised of five talks each. Two sessions, comprised of seven talks each, will be composed of speakers chosen from submitted abstracts of participants based on scientific content with special attention given to younger investigators. Ample time will be reserved between all presentations for questions and discussion by the audience. In addition, two poster sessions are planned to allow all participants to present recent findings.

描述：此申请要求为会议的部分资金 泛素和细胞内蛋白质降解将于1997年6月28日举行 至1997年7月3日在佛蒙特州学院会议中心萨克斯顿 弗吉尼亚州河。 这次每两年一次的会议于1989年启动，是 由联邦联合会赞助并获得部分资金 美国实验生物学社会（FASEB）。 这是唯一的 定期安排的国际会议专门针对这一重要领域 研究。 细胞内蛋白质降解的机理和调节是 在确定总体蛋白质含量和稳定的基本上重要性 特定细胞内蛋白质的状态水平。 中心途径 桉树内的蛋白质更新是泛素和ATP依赖性的， 需要26S蛋白酶体。 泛素是低分子量，高度 保守的多肽通过其共价发挥其生物学作用 在需要ATP的酶促途径中与其他蛋白质结合 水解。 泛素与蛋白质的连接，或更正确地 多泛素链的形成是识别信号 通过特异性结合靶蛋白与26S蛋白酶体的结合 与蛋白酶体的19S调节复合物的亚基5A相互作用。 该途径负责组成性的降级和 有条件短暂的蛋白质，包括异常结构的蛋白质 由环境压力或突变以及其他各种钥匙产生 调节蛋白包括转录因子，癌基因，膜 受体和细胞周期蛋白。 1997年的会议将组织成9次会议，由五个会议组成 每个说话。 两个会议由七个演讲组成，将组成 从参与者提交的摘要中选择的演讲者 科学内容特别关注年轻的研究人员。 在所有演示文稿之间将保留足够的时间，以解决问题和 观众的讨论。 此外，计划两次海报会议 允许所有参与者提出最新发现。