UBIQUITIN AND INTRACELLULAR PROTEIN

泛素和细胞内蛋白

• 批准号: 3435118
• 负责人: ALFRED L GOLDBERG
• 金额: $ 0.35万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435118
• 关键词: meeting /conference /symposium; protein degradation; proteolysis; travel; ubiquitin

This application requests partial funding for a conference on UBIQUITIN AND INTRACELLULAR PROTEOLYTIC DEGRADATION, to be held June 9-14, 1991 at Saxtons River, VT. This conference is sponsored by and receives partial support from the Federation of the American Societies of Experimental Biology (FASEB). The first international meeting of this group convened in 1989 under the guidance of FASEB. The meeting was such a success that the conferees unanimously approved meeting again every other year. The 1991 meeting format will consist of nine formal sessions (two each day-in the morning and evening-except for Friday when there will be only a morning session) with four to five invited speakers at each session. Ample time will be set aside for posters, informal talks and discussion. The chairperson will provide a brief overview and background for the particular session. The maj"or focus of this conference is on ubiquitin and biochemical systems for the intracellular degradation of protein. Ubiquitin is a small, highly conserved eukaryotic protein. It functions in protein breakdown by becoming covalently linked to other proteins and then serves as a reuseable recognition signal for proteolysis. It is also involved in chromatin structure, cell/cell interactions, signal transduction, DNA repair, cell cycle, cytoskeleton, ribosomal assembly, viruses, and various neuronal diseases (including Alzheimer's) through its attachment to specific proteins, but its role is unclear. The details and breadth of the ubiquitin system are emerging at an ever increasing rate making a meeting of this type important. But, at the same time, it has become clear that this ATP-ubiquitin-dependent system is not the only one employed by cells and in particular, prokaryotes and organelles use other types of ATP-dependent proteolytic enzymes. Discussion of these non-ubiquitin systems in prokaryotes and eukaryotes is also planned. The specific sessions include ubiquitin genes and their expression, enzymes involved in the ubiquitin pathway, recognition signals for ubiquitin conjugation, prokaryotic cell protein degradation, the proteasome, regulation and physiological factors in protein breakdown, and protein degradation in organelles. This is the only major international conference on ubiquitin and protein breakdown and will attempt to bring together investigators working on the regulation of protein degradation in emerging animal, bacterial, and plant systems.

该申请要求为泛素会议提供部分资金 和细胞内蛋白水解降解，将于1991年6月9日至14日在 萨克斯顿河，弗吉尼亚州。 这次会议由并获得部分赞助 美国实验社会联合会的支持 生物学（FASEB）。 该小组的第一次国际会议召集 1989年在Faseb的指导下。 会议很成功 同盟者每隔一年再次一致批准会议。 1991年的会议格式将包括9次正式会议（每次两个 星期五只有 每次会议中有四到五位邀请的演讲者。 将为海报，非正式会谈和讨论留出足够的时间。 主席将为 特定会话。 这次会议的joar或重点是泛素 以及用于蛋白质细胞内降解的生化系统。 泛素是一种小的，高度保守的真核蛋白。它功能 通过与其他蛋白质共价链接，在蛋白质分解中 然后是蛋白水解的可重复识别信号。 这是 还参与染色质结构，细胞/细胞相互作用，信号 转导，DNA修复，细胞周期，细胞骨架，核糖体组装，， 病毒和各种神经元疾病（包括阿尔茨海默氏症） 它的附着在特定蛋白质上，但其作用尚不清楚。 这 泛素系统的细节和广度正在出现 提高利率使这种类型的会议很重要。 但是，在 同时，很明显，这种依赖于ATP泛素的系统 不是唯一由细胞雇用的人，尤其是原核生物和 细胞器使用其他类型的ATP依赖性蛋白水解酶。 讨论原核生物和真核生物中这些非泛素系统 也计划。 具体会议包括泛素基因和 它们的表达，涉及泛素途径的酶，识别 泛素结合，原核细胞蛋白降解的信号， 蛋白质的蛋白酶体，调节和生理因素 分解和细胞器中的蛋白质降解。 这是唯一的 大型国际泛素和蛋白质细分大会以及 将试图将调查人员聚集在一起 新兴动物，细菌和植物系统中蛋白质降解的蛋白质降解。