UBIQUITIN AND INTRACELLULAR PROTEIN DEGRADATION

泛素和细胞内蛋白质降解

• 批准号: 3435038
• 负责人: MILTON J SCHLESINGER
• 金额: $ 0.2万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435038
• 关键词: cell biology; cell components; meeting /conference /symposium; protein metabolism; ubiquitin

This application requests partial funding for a conference on UBIQUITIN AND INTRACELLULAR PROTEOLYTIC DEGRADATION, to be held Ju1y 2-T, 1989 at Saxtons River, CT. This conference is sponsored by the Federation of the American Societies of Experimental biology (FASES) and receives partial support from this group. The format of the meeting will consist of nine formal sessions (two each day- in the morning and evening-except for Friday when there will be only a morning session) with three to five invited speakers at each session. Ample time will be set aside for posters, informal talks and discussion. The chairperson will provide a brief overview and background for the particular session. The major focus of this conference is on ubiquitin and biochemical systems for the intracellular degradation of protein. One of the major pathways for degrading protein inside cells utilizes the small, highly conserved protein called uubiquitin, and details on just how ubiquitin functions in protein turnover have emerged in the past few years. But, at the same time,it has become clear that the ATP- ubiquitin-dependent system is not the only one employed by cells and in particular, the prokaryotes use another type of ATP- dependent ezymatic activity. A discussion of the latter and non- ubiquitin systems in different cellular organelles is planned. Other recent data based on elucidation of ubiquitin coding genes indicate that ubiquitin may play critical regulatory roles involving ribosomal RNA, the cytoskeletor, the chromatin and surface receptors. The specific sessions include ubiquitin genes and their expression, ubiquitin, enzymology, prokaryotic cell protein degradation, the proteasome, regulation and physiological factors in protein breakdown and protein degradation in organelles. This will be the first major corference on ubiquitin and the first meeting to bring together investigators working on distinct intracellular pathways of protein breakdown.

该申请要求部分资金参加会议 泛素和细胞内蛋白水解降解，持有 Ju1y 2-T，1989年在康涅狄格州萨克斯顿河。 这次会议是赞助的 由美国实验生物学社会联合会 （窃听）并获得该组的部分支持。 格式 会议中将包括九次正式会议（每天两次 - 在星期五的早晨和晚上，何时会有 只有一个早上的会议）每个都有三到五个邀请的演讲者 会议。 大量时间将留给海报，非正式会谈 和讨论。 主席将提供简短的概述和 特定会话的背景。 主要重点 会议是关于泛素和生化系统的 蛋白质的细胞内降解。 主要途径之一 用于降解蛋白质内部的蛋白质，利用很小的高度 保守的蛋白质称为Uubiquitin，详细介绍了如何 过去出现了蛋白质周转的泛素功能 几年。 但是，与此同时，很明显ATP- 泛素依赖性系统并不是细胞使用的唯一一个 特别是，原核生物使用另一种类型的ATP- 依赖的酶活性。 讨论后者和非 - 计划在不同的细胞器中进行泛素系统。 基于泛素编码基因的阐明的其他最新数据 表明泛素可能扮演关键的调节角色 涉及核糖体RNA，细胞骨架，染色质和 表面受体。 特定会话包括泛素基因 以及它们的表达，泛素，酶学，原核细胞 蛋白质降解，蛋白酶体，调节和生理 细胞器中蛋白质分解和蛋白质降解的因素。 这将是对泛素的第一个主要焦糖，也是第一个 开会将研究人员聚集在一起 蛋白质分解的细胞内途径。