EUKARYOTIC MRNA PROCESSING CONFERENCE

真核mRNA加工会议

• 批准号: 2624435
• 负责人: Adrian R Krainer
• 金额: $ 0.6万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 1998-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2624435
• 关键词: RNA splicing; eukaryote; meeting /conference /symposium; messenger RNA; polyadenylate; posttranscriptional RNA processing; spliceosomes

The proposed conference on "Eukaryotic mRNA Processing" will convene scientists studying various aspects of mRNA splicing and 3'-end processing mechanisms and regulation in metazoans and in yeast. Major advances have recently been made in these areas, and the proposed conference will be a timely event for discussing the latest unpublished results and exchanging ideas, thereby fostering new developments in this rapidly moving field. The proposed conference is a new meeting to be held every other year at Cold Spring Harbor Laboratory. The first meeting will be held on August 20 - 24, 1997, and is expected to attract 300-400 scientists internationally, who are actively investigating various aspects of messenger RNA maturation in eukaryotic cells, using genetic, biochemical, molecular, and cell biological approaches. The major focus of the first meeting will be on nuclear events in mRNA maturation, particularly mRNA splicing and polyadenylation. It will include eight plenary sessions and two poster sessions. Speakers in the plenary sessions will be selected on the basis of the submitted abstracts, which will encourage active participation by junior scientists. The main topics covered will include: catalytic mechanisms and specificity of mRNA splicing and 3'-end processing; developmental and cell-type specific regulation of gene expression by alternative splicing and polyadenylation, structure and function of snRNP particles and of hnRNPs, SR proteins, PRPs, and other yeast and metazoan protein factors involved in splicing or polyadenylation; spliceosome assembly; an localization and dynamics of processing reactions, factors, substrates, and products, in relation to nuclear architecture and to nuclear-cytoplasmic transport.

拟议的“真核mRNA加工”会议将召开 科学家研究 mRNA 剪接和 3' 末端的各个方面 后生动物和酵母中的加工机制和调节。 最近在这些领域取得了重大进展 拟议的会议将是讨论最新情况的及时活动 未发表的成果并交流想法，从而培育新的 这个快速发展的领域的发展。拟议的会议 是每隔一年在冷泉港举行的一次新会议 实验室。第一次会议将于1997年8月20日至24日举行， 预计将吸引 300-400 名国际科学家 正在积极研究信使RNA的各个方面 真核细胞的成熟，利用遗传、生物化学、 分子和细胞生物学方法。此次会议的主要焦点是 第一次会议将讨论 mRNA 成熟过程中的核事件， 特别是 mRNA 剪接和聚腺苷酸化。它将包括 八次全体会议和两次海报会议。演讲者在 全体会议将根据提交的材料选择 摘要，这将鼓励初级学生积极参与 科学家。涵盖的主要主题包括：催化 mRNA剪接和3'端加工的机制和特异性； 基因表达的发育和细胞类型特异性调控 通过选择性剪接和聚腺苷酸化、结构和功能 snRNP 颗粒和 hnRNP、SR 蛋白、PRP 和其他酵母 和参与剪接或的后生动物蛋白因子 聚腺苷酸化；剪接体组装；本地化和动态 加工反应、因子、底物和产物的 与核结构和核细胞质的关系 运输。