Core D: Analysis Core

核心D：分析核心

• 批准号: 10555685
• 负责人: Michael Paul Lavalley
• 金额: $ 63.91万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555685
• 关键词: Address; Blood; Calcium; Clinical; Clinical Data; Crystal Formation; Data; Data Analyses; Data Analytics; Data Collection; Degenerative polyarthritis; Deposition; Disease Progression; Elderly; Ensure; Epidemiologist; Epidemiology; Exercise; Fright; Funding; Goals; Grant; Image; Image Analysis; Impairment; Incidence; Joints; Knee Osteoarthritis; Knowledge; Machine Learning; Methodology; Methods; Nervous System; Observational Study; Pain; Physical activity; Policies; Procedures; Process; Proteins; Proteomics; Reproducibility; Reproducibility of Results; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Services; Site; Standardization; Synovial Fluid; Techniques; Training; Training and Education; Visualization; Work; advanced analytics; analytical method; clinically relevant; data management; design; experience; insight; meetings; mineralization; multidimensional data; novel; success

ABSTRACT Analysis Core The overarching goal of the Analysis Core is to ensure the success of the MOST4 projects by providing an outstanding data analytic service for analysis plan management, advising on appropriate methodologic approaches, and implementation of high quality analyses. The Analysis Core will provide analytic support for the three major scientific projects in this grant cycle that address key gaps in knowledge in osteoarthritis (OA). This core will institute a process to ensure that rigorous and high quality study design and analytic methods will be instituted in MOST projects and studies, which will be critical for making valid inferences. The MOST Study has made major contributions to our understanding of the course of knee OA, largely due to the sophisticated analyses applied to the comprehensive data collected over the prior three funded cycles of MOST. The specific aims of the Analysis Core are as follows: 1) Provide detailed critical reviews of analysis plans to ensure that appropriate and high quality methods are used to ensure rigor and reproducibility of findings; 2) Develop detailed operational procedures with the Executive Committee to incorporate overall MOST4 study dissemination priorities and help ensure Project leads meet internal and external deadlines; 3) Conduct all analyses for MOST4- approved analysis plans using state-of-the-art methods that address unique statistical issues encountered in OA research and in MOST; 4) Provide ongoing education and training to MOST analysts and investigators to enable projects that rely on imaging and/or multidimensional data (e.g., Project 3: Mineralization) to take advantage of current and evolving methods in advanced analytic techniques including machine learning and visualization. By implementing high quality methods with standardized policies and procedures, the Analysis Core will efficiently manage a large number of analyses in an efficient, rigorous, and transparent manner to contribute to the scientific insights that will be made possible by the vast and rich data collection planned in MOST4.

摘要分析核心 分析核心的总体目标是通过提供 用于分析计划管理的出色数据分析服务，就适当的方法提供建议 方法和高质量分析的实施。分析核心将为 本资助周期中的三个主要科学项目旨在解决骨关节炎 (OA) 知识方面的关键差距。这 核心将制定一个流程，以确保严格和高质量的研究设计和分析方法 大多数项目和研究中都采用了这种方法，这对于做出有效的推论至关重要。 MOST 研究有 为我们了解膝关节 OA 的病程做出了重大贡献，这主要归功于复杂的研究 分析适用于 MOST 前三个资助周期收集的综合数据。具体的 分析核心的目标如下： 1) 提供对分析计划的详细批判性审查，以确保 使用适当和高质量的方法来确保研究结果的严谨性和可重复性； 2）制定详细 与执行委员会合作的操作程序，以纳入总体 MOST4 研究传播 优先事项并帮助确保项目负责人满足内部和外部的最后期限； 3) 对 MOST4- 进行所有分析 使用最先进的方法批准分析计划，解决 OA 中遇到的独特统计问题 研究和 MOST； 4) 为大多数分析师和调查人员提供持续的教育和培训，以使其能够 依赖成像和/或多维数据的项目（例如项目 3：矿化）来利用 先进分析技术中当前和不断发展的方法，包括机器学习和可视化。经过 通过标准化的政策和程序实施高质量的方法，分析核心将有效地 以高效、严谨和透明的方式管理大量分析，为科学做出贡献 MOST4 中计划的庞大而丰富的数据收集将使得这些见解成为可能。