Research and Evaluation Support Core Unit (RESCU Core)

研究与评估支持核心单元（RESCU Core）

• 批准号: 10017051
• 负责人: Michael Paul Lavalley
• 金额: $ 38.04万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017051
• 关键词: Address; Big Data; Biometry; Boston; Clinical; Clinical Research; Cohort Studies; Communities; Data; Databases; Degenerative polyarthritis; Disease; Electronic Health Record; Epidemiologic Methods; Epidemiology; Etiology; Europe; Evaluation; Funding; Future; Goals; Gout; Grant; Health; Health Benefit; Health Technology; Image; Individual; Intelligence; Investigation; Machine Learning; Measures; Mentors; Methodology; Methods; Modernization; Musculoskeletal Diseases; Musculoskeletal Pain; Osteoporosis; Outcome; Patient Self-Report; Persons; Protocols documentation; Randomized; Rehabilitation therapy; Research; Research Design; Research Methodology; Research Personnel; Rheumatism; Rheumatology; Risk Factors; Scleroderma; Services; Spondylarthritis; Statistical Data Interpretation; Students; Training; Universities; Ursidae Family; base; causal model; clinically relevant; cohort; crowdsourcing; design; epidemiology study; improved; innovation; instrument; interest; mHealth; machine learning method; meetings; multidisciplinary; novel; protocol development; statistical service

METHODOLOGY CORE ABSTRACT The Methodology Core of the CCCR will bring together investigators from diverse scientific backgrounds whose research interests are in the specific diseases of focus for this CCCR, osteoarthritis and gout, along with interests in spondyloarthritis, scleroderma, osteoporosis and musculoskeletal pain. By having rheumatology, rehabilitation and epidemiology and biostatistics investigators meet once a week together, the Methodology Core creates interdisciplinary conversations and makes available to clinician researchers methodologic expertise that would otherwise not be part of their grants or scientific projects. As in the prior MCRC, there is a focus in the Methodology Core on epidemiologic studies of established and new cohorts in osteoarthritis and gout. In addition, in the past five years we have developed expertise in addressing epidemiologic questions using large electronic health record databases, especially the Health Improvement Network (THIN). The Boston University CCCR group is well known for training young investigators, many of whom now make up a large segment of the clinical researchers in rheumatology domestically and around the world. The Methodology Core will continue to emphasize training doctoral and postdoctoral students and rheumatology fellows. The overall goals of this methodology core are to provide state of the art methodologic input into clinical research questions in OA, gout and other diseases we study and also to introduce new impactful clinical research methods into the study of these diseases. In addition to providing support for study protocols, design and statistical analysis, modern epidemiologic methods involving causal inference and Mendelian randomization will be used. Further, because they represent major components of the future of clinical research in CCCR diseases, we will include new expertise in machine learning and mobile health technologies.

方法论核心 抽象的 CCCR 的方法论核心将汇集来自不同科学背景的研究人员，他们的 研究兴趣是本次 CCCR 重点关注的特定疾病、骨关节炎和痛风，以及兴趣 用于脊柱关节炎、硬皮病、骨质疏松症和肌肉骨骼疼痛。通过风湿病学、康复治疗 方法学核心创建了流行病学和生物统计学研究人员每周会面一次 跨学科对话，并为临床研究人员提供方法学专业知识， 否则不得成为其资助或科学项目的一部分。与之前的 MCRC 一样，重点是 关于骨关节炎和痛风已建立和新队列的流行病学研究的方法学核心。在 此外，在过去的五年里，我们已经发展了利用大量数据来解决流行病学问题的专业知识。 电子健康记录数据库，特别是健康改善网络（THIN）。波士顿大学 CCCR 小组以培养年轻研究人员而闻名，其中许多人现在已成为研究人员的很大一部分。 国内外风湿病学临床研究人员。方法论核心将继续 重点培养博士生、博士后和风湿病学研究员。 该方法核心的总体目标是为临床研究提供最先进的方法学输入 我们研究 OA、痛风和其他疾病的问题，并引入新的有影响力的临床研究方法 投入到这些疾病的研究中。除了为研究方案、设计和统计提供支持外 分析时，将使用涉及因果推理和孟德尔随机化的现代流行病学方法。 此外，由于它们代表了 CCCR 疾病临床研究未来的主要组成部分，我们将 包括机器学习和移动医疗技术方面的新专业知识。