Asian Cohort for Alzheimer's Disease (ACAD)

亚洲阿尔茨海默病队列 (ACAD)

基本信息

批准号：
10555689
负责人：
HELENA Chang CHUI
金额：
$ 832.6万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555689
关键词：
Address Advocacy Affect Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer’s disease biomarker Area Asia Asian Asian Americans Asian population Awareness Biological Markers Biology Blood Blood specimen Canada Caregivers Categories Chinese Clinical Clinical Data Clinical Research Cognitive Collaborations Collection Communities Community Health Community Outreach Consensus DNA Data Data Collection Data Set Dementia Diagnosis Diagnostic Diet Disease Drug Targeting Etiology European ancestry Family Frequencies Funding Future Genetic Genetic Diseases Genetic Research Genetic study Genotype Gold Health Personnel Health care facility Hour Human Genetics Immigration Infrastructure International Investments Knowledge Koreans Language Leadership Life Experience Life Style Literature Long-Term Care Meta-Analysis Minority Groups Modeling Molecular Neurologic Neurology Participant Pathway interactions Patients Persons Physical activity Plasma Population Population Heterogeneity Procedures Protocols documentation Recording of previous events Research Research Project Grants Resources Risk Risk Factors SNP array Sampling Scientist Socioeconomic Status Staging Training Translating Translation Process United States Variant Vietnamese adjudication aged clinical predictors cohort community engagement data management data sharing effective therapy experience follow-up gene discovery genetic variant genome sequencing genome wide association study genome-wide geriatric depression health disparity improved insight metropolitan multi-ethnic new therapeutic target non-genetic outreach polygenic risk score precision medicine clinical trials prevent quality assurance recruit reference genome repository retention rate risk variant saliva sample screening sex synergism whole genome

项目摘要

Overall Abstract Alzheimer’s disease (AD) affects 5.8 million people in the United States and is an immense burden on our economy, patients and caregivers. Genome-wide association studies (GWAS) have successfully led to 25 genome-wide significant loci associated with AD risk and many more associations with key clinical covariates. Most of these findings are made on participants with European ancestry, although efforts to study other minority populations are taking off. Knowledge about AD genetics among Asian Americans is especially limited due to lack of participants. Comprising 6% of the US populace, Asian Americans are under-sampled and deserve more scientific investment. We propose the Asian Cohort for Alzheimer’s Disease (ACAD), the first large Alzheimer’s Disease (AD) genetics cohort for Asians in United States (US) and Canada. To address recruitment barriers, we assembled a team of scientists, clinicians, and community partners with collaborative history and expertise in AD research, human genetics, and Asian community outreach. We propose to recruit 5,081 participants aged 60 years or older and of Chinese, Korean, and Vietnamese ancestry from metropolitan areas across US and Canada in collaboration with community health providers or long-term care facilities that serve Asian communities. We will collect DNA and plasma biomarkers and use validated, translated data collection forms and clinical/diagnostic protocols. To support these recruitment and data collection activities, we will form six Cores that provide administrative oversite, outreach, clinical expertise, data management, biosample management, and training and quality assurance to support recruitment and analysis activities. All samples will be genotyped using SNP arrays and imputed using a large Asian-specific reference panel of whole genome sequencing data from international Asian cohorts. We propose two Research Projects that will analyze genetic, biomarker and clinical data to investigate impact of lifestyle risk factors, genetic variants for AD risk, evaluate differential effects of sex and APOE genotypes on AD risk, and predict clinical diagnosis of AD using genetic and lifestyle risk scores. We will replicate these findings through meta-analysis collaborations with international Asian cohorts and AD studies from other populations.

总体摘要阿尔茨海默病 (AD) 影响着美国 580 万人，对我们来说是一个巨大的负担经济、患者和护理人员的全基因组关联研究 (GWAS) 已成功得出 25 项结论。与 AD 风险相关的全基因组显着位点以及与关键临床协变量的更多关联。这些发现大部分是针对参与者得出的，尽管他们有欧洲血统，但努力研究其他少数族裔群体对亚裔美国人 AD 遗传学的了解尤其有限。由于缺乏参与者，亚裔美国人占美国人口的 6%，样本不足，而且值得更多的科学投资。我们提出了亚洲阿尔茨海默病队列 (ACAD)，这是第一个大型阿尔茨海默病 (AD) 为了解决招募障碍，我们聚集了美国和加拿大的亚洲人遗传学队列。一支由科学家、忠诚者和社区合作伙伴组成的团队，在 AD 研究方面具有合作历史和专业知识，我们建议招募 5,081 名 60 岁或以上的参与者。来自美国和加拿大大都市地区的老年人，有中国、韩国和越南血统与为亚洲社区服务的社区卫生服务提供者或长期护理机构合作。将收集 DNA 和血浆生物标志物，并使用经过验证、翻译的数据收集表格，为了支持这些招募和数据收集活动，我们将形成六个核心。提供现场管理、外展、临床专业知识、数据管理、生物样本管理、支持招募和分析活动的培训和质量保证。使用 SNP 阵列进行基因分型，并使用大型亚洲特定全基因组参考面板进行估算我们提出了两个研究项目来分析遗传、生物标志物和临床数据，用于调查生活方式风险因素、AD 风险遗传变异的影响，评估性别和 APOE 基因型对 AD 风险的差异影响，并利用遗传预测 AD 的临床诊断我们将通过与以下机构的荟萃分析合作复制这些发现。国际亚洲队列和其他人群的 AD 研究。