RADON LEVELS, CIGARETTE SMOKING & CANCER

氡气水平，吸烟

• 批准号: 2311210
• 负责人: JAN A STOLWIJK
• 金额: $ 19.97万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2311210
• 关键词: RADON; LEVELS; CIGARETTE; SMOKING; CANCER

Recent surveys indicate that between 10 and 20 percent of homes in the United States have indoor radon levels that exceed EPA's guideline level for remedial action. It has been estimated that indoor radon pollution accounts for 5,000 to 20,000 lung cancer deaths each year. This estimates is extrapolated from studies of miners with very high radon exposures; results which may not be generalizable to the population at large. Cigarette smoking is the overwhelming risk factor for lung cancer and there is evidence to suggest that effects from radon may be greater in smokers. However, the nature of the possible interaction between radon smoking has not been adequately quantified. Furthermore, while most studies have focused on lung cancer risk, the possibility of broader effects of radon exposure cannot be ruled out. Accordingly, the relationship between cumulative residential exposure to radon and cancer risk will be explored in Connecticut, in a population-based study of approximately 400 nonsmokers and 600 smokers with lung cancer and a similar number of matched comparison subjects without lung cancer chosen by random population screening. Incident cancer cases identified through a statwide cancer registry will be collected over a 3 year period. Detailed residential histories will be obtained and radon measurements will be made in past homes in order to estimate cumulative radon exposure for each subject. The joint and interactive effects of radon and cigarette smoke exposure on lung cancer risk will be evaluated. In a preliminary companion study, cumulative radon and background gamma radiation exposure will also be determined for approximately 125 childhood cancer cases and 250 healthy controls.

最近的调查表明，10% 到 20% 的人 美国家庭的室内氡气浓度超过 EPA 的补救措施指导水平。 已估计 室内氡污染占5000至20000个肺 每年癌症死亡人数。 该估计值是从 对氡气暴露量极高的矿工进行的研究；结果 可能无法推广到广大人群。 卷烟 吸烟是肺癌的首要危险因素 有证据表明氡气的影响可能是 吸烟者中更严重。 然而，可能的性质 氡气吸烟之间的相互作用尚未得到充分研究 量化。 此外，虽然大多数研究都集中在 肺癌风险，氡可能产生更广泛的影响 不能排除暴露的可能性。 因此，关系 住宅累积接触氡气与癌症之间的关系 康涅狄格州将在一项基于人群的研究中探讨风险 大约 400 名非吸烟者和 600 名患有肺癌的吸烟者 癌症和相似数量的匹配比较对象 通过随机人群筛查选择无肺癌的患者。 通过全州范围的癌症发​​现的癌症病例 注册表将在 3 年的时间内收集。 详细的 将获得居住历史和氡气测量值 将在过去的房屋中进行，以估计累积的 每个受试者的氡暴露量。 联合互动 氡气和香烟烟雾暴露对肺癌的影响 将评估风险。 在一项初步的同伴研究中， 累积的氡气和背景伽马辐射暴露将 还确定了大约 125 例儿童癌症病例 和 250 名健康对照。